The Synthesis, Fate and Function of Histidine-Rich Proteins in the Stratum Corneum

  • I. R. Scott
  • C. R. Harding
  • J. G. Barrett


It has been known for many years that a major component of keratohyalin granules is the so-called histidine-rich protein. In recent years it has become evident that multiple forms of these proteins are present both in keratohyalin granules and in the stratum corneum. The form in the keratohyalin granules is extensively phosphorylated [6, 10], while the stratum corneum forms are very basic.


Free Amino Acid Stratum Corneum Urocanic Acid Tape Strip Keratohyalin Granule 
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  1. 1.
    Barrett JG, Scott IR (to be published) Pyrrolidone carboxylic add synthesis in mammalian epidermis. J Invest DermatolGoogle Scholar
  2. 2.
    Beaven MA, Wilcox G, Terpstra GK (1978) A microprocedure for the measurement of 14CO2 release from [14C] carboxyl labelled amino acids. Anal Biochem 84: 638–641PubMedCrossRefGoogle Scholar
  3. 3.
    Brody I (1977) Ultrastructure of the stratum corneum. Dermatology 16: 245–256CrossRefGoogle Scholar
  4. 4.
    Dale BA, Holbrook KA, Steinert PM (1978) Assembly of stratum corneum basic protein and keratin filaments in macrofibrils. Nature 276: 729–731PubMedCrossRefGoogle Scholar
  5. 5.
    Kubilus J, Baden HP (1978) Enzymatic conversion of protein bound arginine to protein bound citrulline in epidermis. Fed Proc 37: 1780Google Scholar
  6. 6.
    Lonsdale-Eccles JD, Haugen JA, Dale BA (1980) A phosphorylated, keratohyalin derived, precursor of epidermal stratum corneum basic protein. J Biol Chem 255: 2235–2238PubMedGoogle Scholar
  7. 7.
    Pratzel H, Geiger K (1977) Biochemistry of the free amino acids in the stratum corneum of human epidermis I. Arch Dermatol Res 259: 151–156PubMedCrossRefGoogle Scholar
  8. 8.
    Pratzel H, Chlebarov S, Dana P (1978) Biochemistry of free amino acids in the stratum corneum of human epidermis II. Arch Dermatol Res 281: 95Google Scholar
  9. 9.
    Scott IR (1981) Factors controlling the expressed activity of histidine ammonia-lyase in the epidermis and the resulting accumulation of urocanic acid. Biochem J 194: 829–838PubMedGoogle Scholar
  10. 10.
    Scott IR, Harding CR (1981) Studies on the synthesis and degradation of a high molecular weight, histidine rich phosphoprotein from mammalian epidermis. Biochim Biophys Acta 669: 65–78PubMedGoogle Scholar
  11. 11.
    Steinert PM, Cantieri JS, Teller DC, Lonsdale-Eccles JD, Dale BA (1981) Characterisation of a class of cationic proteins that specifically interact with intermediate filaments. Proc Natl Acad Sci USA 78: 4097–4101PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • I. R. Scott
    • 1
  • C. R. Harding
    • 1
  • J. G. Barrett
    • 1
  1. 1.Unilever Research Colworth LaboratorySharnbrookUK

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