Abstract
Hölzle and Plewig [3] found the cells from sites of atopic dermatitis were 15% smaller than normal in terms of surface area. Topical corticosteroids seemed to reverse this finding, in that corneocytes of normal size were found after treatment. The authors suggested that abnormally small cells reflected an increased epidermal cell turnover. Goldschmidt [2] detected abnormally small corneocytes from psoriatic lesions which increased in surface area after intralesional injection of corticosteroids.
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References
Delforno C, Holt PJA, Marks R (1978) Corticosteroid effect on epidermal cell size. Br J Dermatol 98: 619
Goldschmidt H (1979) Surface area measurements of psoriatic corneocytes: Effects of intra- lesional steroid therapy. J Invest Dermatol 73: 558–560
Hölzle E, Plewig G (1977) Effects of dermatitis, stripping and steroids on the morphology of corneocytes. A new bioassay. J Invest Dermatol 68: 350–356
Tree S, Marks R (1975) An explanation for the ‘placebo’ effect of bland ointment bases. Br J Dermatol 92: 195–198
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© 1983 Springer-Verlag Berlin Heidelberg
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Nicholls, S., Lawson, A., Barton, S.P., Marks, R. (1983). Changes in Corneocyte Size After Application of Topical Corticosteroids and Vehicles to Normal Skin. In: Marks, R., Plewig, G. (eds) Stratum Corneum. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68682-5_32
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DOI: https://doi.org/10.1007/978-3-642-68682-5_32
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