The Significance of the Size and Shape of Corneocytes
In the past half century we have learned about most of what the stratum corneum does but very little about how it does it. We can document its various functions but are mostly silent when questioned as to which structural components are responsible for these functions. Corneocytes differ quite markedly from the keratinocytes that produce them. The most obvious difference is the disc-like shape of the corneocyte, allowing it to present a large surface area in the horizontal dimension. It seems reasonable to suggest that this difference in shape and surface area has important functional implications in the SC. This paper sets out to examine these and also to discuss those factors known to influence the size and shape of corneocytes.
KeywordsPermeability Corticosteroid Shrinkage Psoriasis Dermatitis
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- 7.King CS, Nicholls S, Barton SP, Marks R (1979) Is the stratum corneum of uninvolved psoriatic skin abnormal? Acta Derm Venereol [Suppl] (Stockh) 59: 95–100Google Scholar
- 12.Marks R, Barton SP (1980) The increase in epidermal cell size during differentiation: Measurement and significance. (Abstr) J Invest Dermatol 74/16: 449Google Scholar
- 14.Mishima Y (1971) Scanning electron microscopy of psoriatic human epidermis. Acta Derm Venerol (Stockh) 51: 16Google Scholar
- 16.Nilsson G, Sedin G, Oberg A (1975) A transducer for measurement of evaporation from the skin. International Conference on Biomedical Transducers. Paris. November, 1975 B 5.3 p71–76Google Scholar