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Pharmacokinetics of β-Blockers in the Elderly

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Beta-Blockers in the Elderly

Abstract

The pharmacological profile of a drug is dependent on its pharmacodynamics, i.e., its mode of action at the target organs, and on its pharmacokinetic parameters. These parameters include the liberation of the drug from its formulation, its absorption from the site of application, its distribution within the body, and its elimination via metabolism and excretion, and thus determine how the drug gets access to its target organs.

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References

  1. Arndts D, Pollmann W (1973) The pharmacokinetics and metabolism of Kö 592 in man, dog and rat. Naunyn Schmiedebergs Arch Pharmacol 277: 349–362

    Article  PubMed  CAS  Google Scholar 

  2. Bakerman S (1969) Aging life processes. CC Thomas, Springfield I

    Google Scholar 

  3. Bender AD (1965) The effect of increasing age on the distribution of peripheral blood in man. J Am Geriatr Soc 13: 192–198

    PubMed  CAS  Google Scholar 

  4. Bender AD (1968) Effect of age on intestinal absorption: implications for drug absorption in the elderly. J Am Geriatr Soc 16: 1331–1339

    PubMed  CAS  Google Scholar 

  5. Brogden RN, Heel RC, Speight TM, Avery GS (1977) Metoprolol: a review of its pharmacological properties and therapeutic efficacy in hypertension and angina pectoris. Drugs 14: 321–348

    Article  PubMed  CAS  Google Scholar 

  6. Brogden RN, Speight TM, Avery GS (1975) Timolol: a preliminary report of its pharmacological properties and therapeutic efficacy in angina and hypertension. Drugs 9: 164–177

    Article  PubMed  CAS  Google Scholar 

  7. Castleden CM, George CF (1979) The effect of aging on the hepatic clearance of propranolol. Br JC in Pharmacol 7: 49–54

    CAS  Google Scholar 

  8. Castleden CM, Kaye CM, Parsons RL (1975) The effect of age on plasma levels of propranolol and practolol in man. Br J Clin Pharmacol 2: 303–306

    PubMed  CAS  Google Scholar 

  9. Coper H, Schulz G (1980) Pharmakotherapie im Alter. Urban & Schwarzenberg, München Wien Baltimore

    Google Scholar 

  10. Dietze F, Laue R (1976) Altern und Resorption. Z Inn Med 31: 114–117

    CAS  Google Scholar 

  11. Dillon N, Chung S, Kelly J, O’Malley K (1980) Age and beta-adrenoceptor-mediated function. Clin Pharmacol Ther 27: 769–772

    Article  PubMed  CAS  Google Scholar 

  12. El-Rashidi R (1981) Estimation of the systemic bioavailability of timolol in man. Biopharm Drug Disposit 2: 197–202

    Article  Google Scholar 

  13. Evans GH, Nies AS, Shand DG (1973) The disposition of propranolol. III. Decreased half life and volume of distribution as a result of plasma binding in man, monkey, dog and rat. J Pharmacol Exp Ther 186: 114–122

    PubMed  CAS  Google Scholar 

  14. Hahn HP von (1979) Das biologische Altern. Sandoz, Nuernberg

    Google Scholar 

  15. Heel RC, Brodgen RN, Pakes GE, Speight TM, Avery GS (1980) Nadolol: a review of its pharmacological properties and therapeutic efficacy in hypertension and angina pectoris. Drugs 20: 1–23

    Article  PubMed  CAS  Google Scholar 

  16. Heel RC, Brodgen RN, Speight TM, Avery GS (1979) Timolol: A review of its therapeutic efficacy in the topical treatment of glaucoma. Drugs 17: 38–55

    Article  PubMed  CAS  Google Scholar 

  17. Heel RC, Brodgen RN, Speight TM, Avery GS (1979) Atenolol: a review of its pharmacological properties and therapeutic efficacy in angina pectoris and hypertension. Drugs 17: 425–460

    Article  PubMed  CAS  Google Scholar 

  18. Heel RC, Brodgen RN, Speight TM, Avery GS (1981) Penbutolol: a preliminary review of its pharmcological properties and therapeutic efficacy in hypertension and angina pectoris. Drugs 22: 1–2

    Article  PubMed  CAS  Google Scholar 

  19. Ishizaki T, Hirayama H, Tawara K, Nakaya H, Sato M, Sato K (1980) Pharmacokinetics and pharmacodynamics in young normal and elderly hypertensive subjects: a study using Sotalol as a model drug. J Pharmacol Exp Ther 212: 173–181

    PubMed  CAS  Google Scholar 

  20. Johnsson G, Regardh C-G (1976) Clinical pharmacokinetics of β-adrenoreceptor blocking drugs. Clin Pharmacokinet 1: 233–263

    Article  PubMed  CAS  Google Scholar 

  21. Kendall MJ, Brown D, Yates RA Plasma metoprolol concentrations in young, old, and hypertensive subjects.

    Google Scholar 

  22. Lundborg P, Steen B (1976) Plasma levels and effect on heart rate and blood pressure of metoprolol after acute oral administration in 12 geriatric patients. Acta Med Scand 200: 397–402

    Article  PubMed  CAS  Google Scholar 

  23. Lydtin H, Lohmöller G (1977) Beta-Rezeptorenblocker. Aesopus, Lugano Munich

    Google Scholar 

  24. McKinstry DN, Dreyfuss J Pharmacokinetics of nadolol. In: Gross F (ed) International experience with nadolol a longacting beta-blocking agent. Academic Press, London, pp 31–37

    Google Scholar 

  25. Meier J (1977) Pindolol: a pharmacokinetic comparison with other beta-adrenoceptor blocking agents. Curr Med Res Opinion [Suppl] 4: 31–38

    Article  CAS  Google Scholar 

  26. Noordhoek J (1976) Pharmacokinetics of beta-adrenoceptor blocking agents. In: Saxena PR, Forsyth RP (eds) Beta-adrenoceptor blocking agents. North-Holland, Amsterdam Oxford New York, pp 79–98

    Google Scholar 

  27. Palm D (1977) Adrenerge β-Rezeptoren und β-Rezeptorenblocker. In: Hierholzer K, Rietbrock N (eds) Physiologische und pharmakologische Grundlagen der Therapie. Herzglykoside, β-Rezeptorenblocker, Diuretika. Perimed, Erlangen, pp 119–147

    Google Scholar 

  28. Platt D (1976) Biologie des Alterns. Quelle & Meyer, Heidelberg

    Google Scholar 

  29. Quarterman CP, Kendall MJ, Jack DB (1981) The effect of age on the pharmacokinetics of metoprolol and its metabolites. Br. J Clin Pharmacol 11: 287–294

    PubMed  CAS  Google Scholar 

  30. Richey DP, Bender AD (1977) Pharmacokinetic consequences of aging. Annu Rev Pharmacol Toxicol 17: 49–65

    Article  PubMed  CAS  Google Scholar 

  31. Schneider RE, Bishop H, Yates RA, Quarterman CP, Kendall MJ (1980) Effect of age on plasma propranolol levels. Br J Clin Pharmacol 10: 169–171

    PubMed  CAS  Google Scholar 

  32. Schocken DD, Roth GS (1977) Reduced β-adrenergic receptor concentration in ageing man. Nature 267: 856–858

    Article  PubMed  CAS  Google Scholar 

  33. Shand DG (1974) Pharmacokinetic properties of the β-adrenergic receptor blocking drugs. Drugs 7: 39–47

    Article  PubMed  CAS  Google Scholar 

  34. Shock N (1962) The physiology of ageing. Sci Am 206: 100–111

    Article  PubMed  CAS  Google Scholar 

  35. Smith A J, Tucker GT (1981) Kinetics and biotransformation of adrenergic inhibitors. In: Szekeres L (ed) Handbook of experimental pharmacology, vol 54/11. Adrenergic activators and inhibitors. Springer, Berlin Heidelberg New York, pp 417–504

    Google Scholar 

  36. Timiras PS (1972) Developmental physiology and ageing. Macmillan, New York

    Google Scholar 

  37. Traunecker W, Häselbart V, Brückner S (1980) Bunitrolol. In: Scriabine A (ed) Pharmacology of antihypertensive drugs. Raven Press, New York, pp 303–315

    Google Scholar 

  38. Vestal RE (1978) Drug use in the elderly: a review of problems and special considerations. Drugs 16: 358–382

    Article  PubMed  CAS  Google Scholar 

  39. Vestal RE, Wood AJJ, Branch RA, Shand DG, Wilkinson GR (1979) Effects of age and cigarette smoking on propranolol disposition. Clin Pharmacol Ther 26: 8–15

    PubMed  CAS  Google Scholar 

  40. Vestal RE, Wood AJJ, Shand DG (1971) Reduced β-adrenoeepter sensitivity in the elderly. Clin Pharmacol Ther 26: 181–186

    Google Scholar 

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Authors
  1. C.-J. Estler
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  2. F. Sörgel
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Editor information

Editors and Affiliations

  1. Carl-Korth-Institut für Herz- Kreislauferkrankungen, Waldkrankenhaus St. Marien, Rathsberger Str. 57, 8520, Erlangen, Germany

    Erich Lang

  2. Institut für Rechtsmedizin, Universität Erlangen-Nürnberg, Universitätsstraße 22, 8520, Erlangen, Germany

    Fritz Sörgel

  3. Universitäts-Nervenklinik, 8520, Erlangen, Germany

    Lothar Blaha

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© 1982 Springer-Verlag Berlin Heidelberg

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Estler, CJ., Sörgel, F. (1982). Pharmacokinetics of β-Blockers in the Elderly. In: Lang, E., Sörgel, F., Blaha, L. (eds) Beta-Blockers in the Elderly. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68674-0_2

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  • DOI: https://doi.org/10.1007/978-3-642-68674-0_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-11682-0

  • Online ISBN: 978-3-642-68674-0

  • eBook Packages: Springer Book Archive

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