Skip to main content
SpringerLink
Log in

Indications for β-Blockers in Glaucoma Patients

  • Conference paper
Beta-Blockers in the Elderly

  • 50 Accesses

Abstract

Since the supplementation of our antiglaucomatous drug armamentarium by the β-blockers, a lot of enthusiastic reports have been published on this new drug system for glaucoma therapy [1–6]. Within a very few years, the acceptance of β-blockers by glaucoma patients turned out to be better than that of other drug system. Before the introduction of the β-blockers, miotics and epinephrine dominated glaucoma therapy. Since β-blockers lack the visual annoyances of miotics and they also lack the high incidence of local ocular irritations of epinephrine compounds, therapists soon found that the patients’ compliance is better with β-blockers [7]. However, in recent years we have had to realize that our initial appreciation of the role of β-blockers in glaucoma therapy was somewhat exaggerated, and that these drugs can also bear the potential of serious side effects [8–12]. The present review tries to weigh the pros and cons of this new drug system in glaucoma therapy and to fit β-blockers into the current therapeutic scheme against glaucoma.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Zimmerman TJ, Kaufmann HE (1977) Timolol - Dose response and duration of action. Arch Ophthalmol 95: 605

    PubMed  CAS  Google Scholar 

  2. Zimmerman TJ, Boger WP (1979) The β-adrenergic blocking agents and the treatment of glaucoma. Surv Ophthalmol 23: 347

    Article  PubMed  CAS  Google Scholar 

  3. Boger WP, Puliafito CA, Steinert RF, Langston DP (1978) Long-term experience with Timolol ophthalmic solution in patients with open angle glaucoma. Ophthalmology 85: 259

    PubMed  Google Scholar 

  4. Boger WP (1978) β adrenergic blocking agents and glaucoma. JCE Ophthalmology 14

    Google Scholar 

  5. Boger WP (1979) The treatment of glaucoma: role of β-blocking agents. Drugs 18: 25

    Article  PubMed  Google Scholar 

  6. Radius RL, Diamond GR, Pollack IP, Langham ME (1978) Timolol. A new drug for management of chronic simple glaucoma. Arch Ophthalmol 96: 1003

    PubMed  CAS  Google Scholar 

  7. Worthen DM (1979) Patient compliance and the “Usefulness product” of Timolol. Surv Ophthalmol 23: 403

    Article  PubMed  CAS  Google Scholar 

  8. Van Buskirk EM (1980) Adverse reactions from Timolol administration. Ophthalmology 87: 447

    PubMed  Google Scholar 

  9. Britman NA (1979) Cardiac effects of topical Timolol. N Engl J Med 300: 566

    PubMed  CAS  Google Scholar 

  10. Van Buskirk EM (1979) Corneal anesthesia after Timolol maleate therapy. Am J Ophthal 88: 739

    PubMed  Google Scholar 

  11. Jones FL (1979) Systemic β-blockade by Timolol eye drops. N Engl J Med 301: 270

    PubMed  Google Scholar 

  12. Nielsen NV, Eriksen JS (1979) Timolol: transitory manifestations of dry in long term treatment. Acta Ophthalmol 57: 418

    CAS  Google Scholar 

  13. Krieglstein GK, Sold-Darseff J, Leydhecker W (1977) The intraocular pressure response of glaucomatous eyes to topically applied bupranolol. A pilot study. Albrecht von Graefes Arch Klin Exp Ophthalmol 202: 81

    Article  PubMed  CAS  Google Scholar 

  14. Krieglstein GK (1979) Response of the intraocular pressure to various β-blocking agents. In: Krieglstein GK, Leydhecker W (eds) Glaucoma update. Springer, Berlin Heidelberg New York

    Chapter  Google Scholar 

  15. Krieglstein GK (1981) The long-term ocular and systemic effects of topically applied Metoprolol tartrate in glaucoma and ocular hypertension. Acta Ophthalmol 59: 15

    CAS  Google Scholar 

  16. Wettreil K (1977) β-adrenoceptor antagonism and intraocular pressure. A clinical study on Propranolol, Practolol and Atenolol. Acta Ophthalmol [Suppl] 134

    Google Scholar 

  17. Wettreil K, Wilke K, Pandolfi M (1978) Topical Atenolol versus Pilocarpine: a double- blind study of the effect on ocular tension. Br J Ophthalmol 62: 292

    Article  Google Scholar 

  18. Krieglstein GK (1978) Die Wirkung von Timolol-Augentropfen auf den Augeninnendruck von Glaucoma simplex. Klin Monatsbl Augenheilkd 172: 75

    Google Scholar 

  19. Krieglstein GK (1980) Timolol: Acute versus chronic intraocular pressure responses. Res Clin Forums 2: 189

    Google Scholar 

  20. Krieglstein GK (1980) β-blocker therapy for glaucoma. In: Perspectives on current glaucoma therapy. Excerpta Medica, Amsterdam Princeton London Geneva New York

    Google Scholar 

  21. Bischoff P (1978) Erfahrungen mit Timolol in der Glaukomtherapie. Klin Monatsbl Augenheilkd 173: 202

    PubMed  CAS  Google Scholar 

  22. Krieglstein GK (1978) Zur Tachyphylaxie von β-Rezeptorenblockern am Glaukomauge. Ber Dtsch Ophthalmol Ges 75: 357

    Google Scholar 

  23. Krieglstein GK (1979) Langzeituntersuchungen zur augendrucksenkenden Wirkung von Timolol-Augentropfen. Klin Monatsbl Augenheilkd 175: 627

    PubMed  CAS  Google Scholar 

  24. Dausch D, Michelson W, Lorenz D (1979) Die Langzeitbehandlung des Weitwinkelglaukoms mit Timolol. Klin Monatsbl Augenheilkd 174: 127

    PubMed  CAS  Google Scholar 

  25. Radius RL, Diamond GR, Pollack IP, Langham ME (1978) Timolol - A new drug for management of chronic simple glaucoma. Arch Ophthalmol 96: 1003

    PubMed  CAS  Google Scholar 

  26. Nielsen NV (1978) Timolol: hypotensive effect, used alone and in combination for treatment of increased intraocular pressure. Acta Ophthalmol 56: 504

    CAS  Google Scholar 

  27. Kerty E, Horven I (1978) Glaucoma treatment with Timolol. Acta Ophthalmol 56: 705

    CAS  Google Scholar 

  28. Spaeth GL (1981) Place of timolol in the treatment of glaucoma. Symp on Glaucoma Trans New Orleans Acad Ophthalmol Mosby, St Louis

    Google Scholar 

  29. Steinert RF, Thomas JV, Boger WP (1981) Long-term drift and continued efficacy after multiyear Timolol therapy. Arch Ophthalmol 99: 100

    PubMed  CAS  Google Scholar 

  30. Kaufman HE (1980) 1. Timolol maleate. Ophthalmology 87: 164

    Google Scholar 

  31. Heel RC, Brogden RN, Speight TM, Avery GS (1979) Timolol: a review of its therapeutic efficacy in the topical treatment of glaucoma. Drugs 17: 38

    Article  PubMed  CAS  Google Scholar 

  32. Krieglstein GK, Gramer E, Leydhecker W (1980) The ocular responses of oral administration of Penbutolol in the glaucomatous patient. Acta Ophthalmol 58: 608

    CAS  Google Scholar 

  33. Drance SM (1970) Use of sympathomimetic and sympatholytic agents in the manage of the glaucomas. In: Symposium on ocular pharmacology and therapeutics. Trans New Orleans Acad Ophthalmol Mosby, St Louis

    Google Scholar 

  34. Boger WP, Steinert RF, Puliafito CA, Pavan-Langston D (1978) Clinical trial comparing Timolol ophthalmic solution to Pilocarpine in open-angle glaucoma. Am J Ophthalmol 86: 8

    PubMed  Google Scholar 

  35. Airaksinen PJ (1979) The long-term hypotensive effect of Timolol maleate compared with the effect of pilocarpine in simple and capsular glaucoma. Acta Ophthalmol 57: 425

    CAS  Google Scholar 

  36. Moss AP, Ritch R, Hargett NA, Kohn AN, Smith H, Podos SM (1978) A comparison of the effects of Timolol and Epinephrine on intraocular pressure. Am J Ophthalmol 86: 489

    PubMed  CAS  Google Scholar 

  37. Sonntag JR, Brindley GO, Shields MB, Arafat NT, Phelps CD (1979) Timolol and Epinephrine. Comparison of efficacy and side effects. Arch Ophthalmol 97: 273

    PubMed  CAS  Google Scholar 

  38. Sonty S, Schwartz B (1979) The additive effect of Timolol on open angle glaucoma patients on maximal medical therapy. Surv Ophthalmol 23: 381

    Article  PubMed  CAS  Google Scholar 

  39. Ashburn FS, Gillespie JE, Kass MA, Becker B (1979) Timolol plus maximum tolerated antiglaucoma therapy: a one-year follow up study. Surv Ophthalmol 23: 389

    Article  PubMed  Google Scholar 

  40. Leydhecker W, Krieglstein GK (1979) The intraocular pressure responses of low-dose Bupranolol (Ophtorenin®) and Methazolamide (Neptazane®) in glaucomatous eyes. Albrecht von Graefes Arch Klin Exp Ophthalmol 210: 135

    Article  CAS  Google Scholar 

  41. Wilson RP, Spaeth GL, Poryzees E (1980) The place of Timolol in the practice of ophthalmology. Ophthalmology 87: 451

    PubMed  CAS  Google Scholar 

  42. Holtmann HW, Holle JP, Glänzer K (1979) Zur Frage der Kontraindikationen bei der Timolol-Behandlung des Glaukoms. 137. Versammlung des Vereins Rheinisch- Westfälischer Augenärzte. Zimmermann, Balve

    Google Scholar 

  43. Fraunfelder FT (1980) Interim report: national registry of possible drug-induced ocular side effects. Ophthalmology 87: 87

    PubMed  CAS  Google Scholar 

  44. Scharrer A, Ober M (1980) Systemic effects of Timolol eyedrops. European Congress of Ophthalmology, April 1980

    Google Scholar 

  45. Wizemann A, Krey H (1981) Thermographische Untersuchungen zum Wirkungsmechanismus von Timolol. Klin Monatsbl Augenheilkd 178: 190

    Article  PubMed  CAS  Google Scholar 

  46. Christini G, Giovannini A (1979) Pressure lowering effect of Timolol with reference to its topical vascular action. Albrecht von Graefes Arch Klin Exp Ophthalmol 211: 325

    Article  Google Scholar 

  47. Langham ME (1981) β-adrenoceptor blocking drugs and the glaucoma suspect. Ann Ophthal. 13: 273

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Univ. Eye Hospital, Josef-Schneider-Str. 11, D-8700, Würzburg, Fed. Rep. Germany

    G. K. Krieglstein

Authors
  1. G. K. Krieglstein
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Carl-Korth-Institut für Herz- Kreislauferkrankungen, Waldkrankenhaus St. Marien, Rathsberger Str. 57, 8520, Erlangen, Germany

    Erich Lang

  2. Institut für Rechtsmedizin, Universität Erlangen-Nürnberg, Universitätsstraße 22, 8520, Erlangen, Germany

    Fritz Sörgel

  3. Universitäts-Nervenklinik, 8520, Erlangen, Germany

    Lothar Blaha

Rights and permissions

Reprints and permissions

Copyright information

© 1982 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Krieglstein, G.K. (1982). Indications for β-Blockers in Glaucoma Patients. In: Lang, E., Sörgel, F., Blaha, L. (eds) Beta-Blockers in the Elderly. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68674-0_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-68674-0_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-11682-0

  • Online ISBN: 978-3-642-68674-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation