Abstract
In 1948, Ahlquist [3] suggested that the adrenergic transmitter noradrenaline and adrenal medullary adrenaline elicit their effects by combining with two kinds of receptors: α and β. More recent studies have shown that β-adrenoceptors are not homogeneous. Lands et al. [18] have suggested a subdivision into β1 and β2. Table 1 shows some adrenergic effects and the type of receptor mainly involved in mediating each effect. α-Receptors mediate, for instance, contraction of smooth muscle in blood vessels and uterus, while β1-receptors mediate cardiac stimulation and other effects such as lipolysis and release of renin.
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References
Åblad B, Carlsson E, Ek L (1973) Pharmacological studies of two cardioselective adrenergic β-receptor antagonists. Life Sci 12, part 1: 107
Åblad B, Ljung B, Sannerstedt R (1976) Haemodynamic effects of β-adrenoreceptor blockers in hypertension. Drugs [Suppl] 11: 127
Ahlquist RP (1948) A study of the adrenotropic receptors. Am J Physiol 153: 586
Carlsson E, Åblad B, Brändström A (1972) Differentiated blockade of the chronotropic effects of various adrenergic stimuli in the cat heart. Life Sci 11, part 1: 953
Carlsson E, Ek L, Lundgren B (1978) Djurfarmakologi. In: Selektiv Beta-Blockad Vid Kardiovaskulär Sjukdom Hässle Läkemedel, Mölndal, pp 8–17
Carlsson E, Fellenius E, Lundborg P, Svensson L (1978) β-adrenoceptor blocker, plasma-potassium, and exercise. Lancet 2: 424
Carlsson E (1979) On the classification and distribution of β-adrenoceptors. Acta Pharmacol Toxicol (Copenh) [Suppl] 44: 17
Clausen T, Flatman JA (1977) The effect of catecholamines on Na-K transport and membrane potential in rat soleus muscle. J Physiol (Lond) 270: 383
Conway J, Wheeler R, Sannerstedt R (1971) Sympathetic nervous activity during exercise in relation to age. Cardiovasc Res 5: 577
Ek L, Björkman J-A, Carlsson E (to be published) Cardiovascular effects of nonselective and β1-selective adrenoceptor antagonists in anaesthetized dogs
Fellenius E, Carlsson E, Åström H, Lipska M, Lundborg P, Svensson L, Bengtsson C, Smith U (1979) Metabolic Effects of BETA-Adrenoceptor Blockade During Exercise. In: 4th Int Symp on Biochemistry of Exercise, June 19–22
Gibson DG (1974) Pharmacodynamic properties of β-adrenergic receptor blocking drugs in man. Drugs 7: 8
Hallbäck-Nordlander M, Ljung B (1980) Långtisbehandling av spontanhypertensiv råtta med en ny antihypertensiv vasodilaterare, H 154/82. Läkemedelslära 4p: 217 Läkaresällskapets Riksstämma XXXVII, Dec 1980
Hansson L, Zweifler AJ, Julius S, Hunyor SN (1974) Hemodynamic effects of acute and prolonged β-adrenergic blockade in essential hypertension. Acta Med Scand 196: 27
Hedberg A, Minneman KP, Molinoff PB (1980) Differential distribution of ß 1 and ß 2- adrenoceptors in cat and guinea-pig heart. J Pharmacol Exp Ther 212: 503
Herwaarden CLA van, Benkhorst RA, Fennis JFM, Van T, Laar A (1977) Effects of adrenaline during treatment with propranolol and metoprolol. Br Med J 1: 1029
Källfelt BJ, Hjalmarson Å, Isaksson OG (1976) In vitro effects on protein synthesis in perfused rat heart. J Mol Cell Cardiol 8: 787
Lands AM, Arnold A, McAuliff JP, Luduena FP, Brown TG Jr (1967) Differentiation of receptor systems activated by sympathomimetic amines. Nature 214: 597
Lakatta EG, Gerstenblith G, Angell CS, Shock NW, Weisfeldt ML (1975) Diminished inotropic response of aged myocardium to catecholamines. Circ Res 36: 262
Maguire ME, Ross EM, Gilman AG (1977) Beta-adrenergic receptor: ligand binding properties and the interaction with adenylate cyclase. Adv Cyclic Nucleotide Res 8: 1
Minneman KP, Hegstrand LR, Molinoff PB (1979) The pharmacological specificity of β1- and β 2-adrenergic receptors in rat heart and lung in vitro. Mol Pharmacol 16: 21
Minneman KP, Hedberg A, Molinoff PB (1979) Comparison of β-adrenergic receptor subtypes in mammalian tissues. J Pharmacol Exp Ther 211: 502
Petch MC, McKay R, Bethune DW (1979) The effect of β2-adrenergic blockade on serum potassium and glucose levels during open heart surgery. Br Heart J 42: 240
Schocken DD, Roth GS (1977) Reduced β-adrenergic receptor concentrations in ageing man. Nature 267: 856
Tarazi RC, Dustan HP (1972) β-adrenergic blockade in hypertension. Practical and theoretical implications of long-term haemodynamic variations. Am J. Cardiol 29: 633
Tivenius L (1976) Effects of multiple doses of metoprolol and propranolol on ventilatory function in patients with chronic obstructive lung disease. Scand J Respir Dis 57: 190
Trimarco B, Ricciardelli B, Volpe M et al. (1980) Echocardiographic assessment of the effect of a long-term treatment with metoprolol on the left ventricle in hypertensive patients. Curr Ther Res Clin Exp 28: 953
Waal-Manning HJ (1976) Metabolic effects of β-adrenoceptor blockers. Drugs [Suppl] 11: 121
Yamori Y, Tarazi RC, Ooshima A (1980) Effect of β-blockers on cardiovascular structural changes in spontaneous and noradrenaline-induced hypertension. Clin Sci 59: 45s
Yin FCP, Raizes GS, Guarneieri T et al. (1978) Age associated decrease in ventricular response to haemodynamic stress during β-adrenergic blockade. Br Heart J 40: 1349
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Åblad, B. (1982). β-Blockers: Theory, Action, and Application to the Elderly. In: Lang, E., Sörgel, F., Blaha, L. (eds) Beta-Blockers in the Elderly. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68674-0_1
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DOI: https://doi.org/10.1007/978-3-642-68674-0_1
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