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Effect of Doxycycline and PUVA Light on Human Polymorphonuclear Leukocyte Function

  • J. Glette
  • A. Halstensen
  • S. Sandberg
  • G. Hopen
  • K. B. Hellum
  • C. O. Solberg

Abstract

Polymorphonuclear leukocytes (PMNLs) are a cornerstone of host defense against infection, and the interaction of PMNLs with antimicrobial agents has been extensively studied [10, 14, 15]. Reports on the effect of tetracyclines on PMNL functions are contradictory. Chlortetracycline and doxycycline seem to markedly inhibit the phagocytic activity of the cells [5, 18] while no such effect has been demonstrated with tetracycline hydrochloride [9]. More recent reports [16, 17] have demonstrated only a slight decrease in phagocytosis of 32P-labeled Escherichia coli by human and rat PMNLs. Doxycycline administrated to healthy individuals has also been shown to slightly inhibit the migration to skin chambers [4].

Keywords

Polymorphonuclear Leukocyte Glucose Oxidation Leukocyte Migration Tetracycline Hydrochloride Ammonium Chloride Solution 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • J. Glette
    • 1
  • A. Halstensen
    • 1
  • S. Sandberg
    • 2
  • G. Hopen
    • 1
  • K. B. Hellum
    • 1
  • C. O. Solberg
    • 1
  1. 1.Medical Department BUniversity of BergenBergenNorway
  2. 2.Laboratory of Clinical BiochemistryUniversity of BergenBergenNorway

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