Effect of Doxycycline and PUVA Light on Human Polymorphonuclear Leukocyte Function

  • J. Glette
  • A. Halstensen
  • S. Sandberg
  • G. Hopen
  • K. B. Hellum
  • C. O. Solberg


Polymorphonuclear leukocytes (PMNLs) are a cornerstone of host defense against infection, and the interaction of PMNLs with antimicrobial agents has been extensively studied [10, 14, 15]. Reports on the effect of tetracyclines on PMNL functions are contradictory. Chlortetracycline and doxycycline seem to markedly inhibit the phagocytic activity of the cells [5, 18] while no such effect has been demonstrated with tetracycline hydrochloride [9]. More recent reports [16, 17] have demonstrated only a slight decrease in phagocytosis of 32P-labeled Escherichia coli by human and rat PMNLs. Doxycycline administrated to healthy individuals has also been shown to slightly inhibit the migration to skin chambers [4].


Polymorphonuclear Leukocyte Glucose Oxidation Leukocyte Migration Tetracycline Hydrochloride Ammonium Chloride Solution 
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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • J. Glette
    • 1
  • A. Halstensen
    • 1
  • S. Sandberg
    • 2
  • G. Hopen
    • 1
  • K. B. Hellum
    • 1
  • C. O. Solberg
    • 1
  1. 1.Medical Department BUniversity of BergenBergenNorway
  2. 2.Laboratory of Clinical BiochemistryUniversity of BergenBergenNorway

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