Abstract
The concept of an infection’s (or parasite’s) basic reproductive rate, R0, is central to an understanding of the population biology of infectious disease agents. This parameter, R0, measures the ability of an infection (or parasite) to give rise to secondary cases (or second generation parasites), and its value is determined by a variety of factors specific to the biology of the disease agent and that of its host. The condition, R0 = 1, defines a transmission threshold below which a disease is unable to maintain itself within the human community. The value of R0 can be estimated from horizontal or longitudinal epidemiological studies of the prevalence and intensity of infection in various age classes of the population. Measurement of this parameter provides a means of estimating the proportion of the community that must be immunized, or receive chemotherapeutic treatment, either to eradicate an infection or to reduce its prevalence to a defined level.
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References
Anderson, R.M., and May, R.M. 1979. Population biology of infectious diseases: part I. Nature 280: 361–367.
Anderson, R.M., and May, R.M. 1982. Directly transmitted infectious diseases: control by vaccination. Science 215: 1053–1060.
Anderson, R.M., and May, R.M. 1982. The population dynamics and control of human helminth infections. Nature, 297: 557–563.
Anderson, R.M., and May, R.M. 1982. The dynamics and control by vaccination of directly transmitted viral and bacterial infections. J. Hyg., in press.
Bailey, N.T.J. 1975. Mathematical theory of infectious diseases, 2nd ed. Macmillan Press: London.
Bartlett, M.S. 1957. Measles periodicity and community size. J.R. Statist. Soc. A 120: 48–70.
Bartlett, M.S. 1960. The critical community size for measles in the United States. J.R. Statist. Soc. A 123: 37–44.
Becker, N.G. 1979. The uses of epidemic models. Biometrics 35: 295–305.
Bruce-Chwatt, L.J., and Glanville, V.J. 1973. The Late George Macdonald. Dynamics of Tropical Diseases. London: Oxford University Press.
Burnet, F.M., and White, D.O. 1972. Natural History of Infectious Diseases. Cambridge: Cambridge University Press.
Creese, A.L., and Henderson, R.H. 1980. Cost-benefit analysis and immunization programmes in developing countries. Bull. WHO 58: 491–497.
Cvjetanovic, B.; Grab, B.; and Uemura, K. 1978. Dynamics of acute bacterial disease. Bull. WHO 56 (Suppl. 1): 1–143.
Dietz, K. 1976. The incidence of infectious diseases under the influence of seasonal fluctuations. In: Mathematical Models in Medicine, eds. J. Berger, W. Buhler, R. Repges, and P. Tautu, vol. 11, pp. 1–15. Lecture Notes in Biomathematics. Berlin: Springer-Verlag.
Dietz, K. 1980. Models for Vector-borne Parasitic Diseases. Lecture Notes in Biomathematics, vol. 39, pp. 264–277. Berlin: Springer-Verlag.
De Quadros, C.A. 1980. More effective immunization. Proc. R. Soc. Lond. B 209: 111–118.
Fine, P.E.M. 1979. John Brownlee and the measurement of infectiousness: an historical study in epidemic theory. J.R. Statist. Soc. A 142: 347–362.
Frost, W.H. 1976. Some conceptions of epidemics in general. Am. J. Epidemiol. 103: 141–151.
Galbraith, N.S.; Forbes, P.; and Mayon-White, R.T. 1980a. Changing patterns of communicable disease in England and Wales: Part I — Newly recognised diseases. Br. Med. J. 281: 427–429.
Galbraith, N.S.; Forbes, P.; and Mayon-White, R.T. 1980b. Changing patterns of communicable disease in England and Wales: Part II — Disappearing and declining diseases. Br. Med. J. 281: 448–492.
Grossman, Z. 1980. Oscillatory phenomena in a model of infectious diseases. Theor. Pop. Biol. 18: 204–243.
Knox, E.G. 1980. Strategy for rubella vaccination. Int. J. Epidemiol. 9 : 13–23.
May, R.M. 1977. Togetherness among schistosomes: its effects on the dynamics of the infection. Math. Biosci. 35: 301–343.
May, R.M., and Anderson, R.M. 1979. Population biology of infectious diseases: Part II. Nature 280: 455–461.
Muench, H. 1959. Catalytic Models in Epidemiology. Cambridge, MA: Harvard University Press.
Smith, C.E.G. 1970. Prospects for the control of infectious diseases. Proc. R. Soc. Med. 63: 1181–1189.
Tyrrell, D.A.J. 1980. Approaches to the control of respiratory virus diseases. Bull. WHO 58: 513–518.
Yorke, J.A.; Hethcote, H.W.; and Nold, A. 1978. Dynamics and control of the transmission of gonorrhea. Sex. Trans. Dis. 5: 51–56.
Yorke, J.A.; Nathanson, N.; Pianigiani, G.; and Martin, J. 1979. Seasonality and the requirements for perpetuation and eradication of viruses in populations. Am. J. Epidemiol. 109: 103–123.
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© 1982 D. Bernhard, Dahlem Konferenzen, Berlin
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Anderson, R.M. (1982). Transmission Dynamics and Control of Infectious Disease Agents. In: Anderson, R.M., May, R.M. (eds) Population Biology of Infectious Diseases. Dahlem Workshop Reports, vol 25. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68635-1_9
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