Abstract
When one analyzes the large number of children with mental retardation, cerebral palsy, and other developmental defects of the nervous system, a majority are classified as having “congenital defects of the nervous system.” Often the pathological description is one of the end stages of disease with little clue as to the timing or mechanism of the disease process. In this paper we review normal development of the human brain at the cellular level, present selected examples of pathological processes that alter development, and finally propose questions about how knowledge of development may lead to promoting possible mechanisms of repair.
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References
Buell, S.J., and Coleman, P.D. 1979. Dendritic growth in the aged human brain and failure of growth in senile dementia. Science 206; 854–856.
Burchfiel, J.L.; Duchowny, M.S.; and Duffy, F.H. 1979. Neuronal supersensitivity to acetylcholine induced by kindling in the rat hippocampus. Science 204; 1096–1098.
Caviness, Jr., V.S.; Pinto-Lord, M.C.; and Evrard, P. 1981 The development of laminated pattern in the mammalian neocortex. In Morphogenesis and Pattern Formation, eds. T.G. Connelly, L.L. Brinkley, and B.M. Carlson, pp. 103–115. New York: Raven Press.
Cowan, W.M. 1978. Aspects of neural development. In International Review of Physiology: Neurophysiology III, ed. R. Porter, vol. 17, pp. 149 - 191. Baltimore: University Park Press.
Dobbing, J., and Sands, J. 1970. Timing of neuroblast multiplication in developing human brain. Nature 226: 639–640.
Goldman-Rakic, P.S. 1981. Development and plasticity of primate frontal association cortex. In The Organization of the Cerebral Cortex, eds. F.O. Schmitt et al., pp. 69– 97. Cambridge: MIT Press.
deGroot, C.J.; Everts, V.B.; Touwen, B.C.L.; and Hommes, F.A. 1978. Non-ketotic hyperglycinemia (NKH): an inborn error of metabolism affecting brain function exclusively. In Progress in Brain Research, Maturation of the Nervous System, eds. M.A. Corner et al., vol. 48, pp. 207–235. Amsterdam: Elsevier Scientific Publishing Co.
Johnson, R.T. 1980. Selective vulnerability of neural cells to viral infections. Brain 103: 447–472.
Lauder, J.M., and Krebs, H. 1978. Serotonin as a differentiation signal in early neurogenesis. Dev. Neurosci. 1: 15–30.
Molliver, M.E.; Kostovic, I.; and van der Loos, H. 1973. The development of synapses in cerebral cortex of the human fetus. Brain Res. 50: 403–407.
Moser, H. 1981. Recent advances in certain disorders of lipid metabolism. In Biomedical Aspects, Frontiers of Knowledge in Mental Retardation, ed. P. Mittler, vol. 2, pp. 239–249. Baltimore: University Park Press.
Rabinowicz, T. 1974. Some aspects of the maturation of the human cerebral cortex. In Modern Problems in Paediatrics, eds. F. Falkner, N. Kretchmer, and E. Rossi, vol. 13, pp. 44–56. Basel: S. Karger.
Rabinowicz, T. 1976. Morphological features of the developing brain. In Brain Dysfunction in Infantile Febrile Convulsions, eds. M.A.B. Brazier and F. Coceani, pp. 1–23. New York: Raven Press.
O’Rahilly, R., and Gardner, E. 1979. The initial development of the human brain. Acta Anat. 104: 123–133.
Purpura, D.P. 1979. Pathobiology of cortical neurons in metabolic and unclassified amentias. In Congenital and Acquired Cognitive Disorders, ed. R. Katzman, pp. 43–68. New York: Raven Press.
Racine, R. 1978. Kindling: The first decade. Neurosurg. 3: 234–252.
Rakic, P. 1978. Neuronal migration and contact guidance in the primate telencephalon. Postgrad. Med. J. 54: 25–40.
Rakic, P. 1981. Neuronal-glial interaction during brain development. Trends Neurosci. 4: 1 84–187.
Steward, V.W., and Jevtic, M.M. 1979. Derangement of neuronal migration in a child with multiple congenital anomalies, two congenital neoplasms, without apparent chromosomal abnormalities. J. Neuropath. Exp. Neurol. 38: 259–285.
Whitehouse, P.J.; Price, D.L.; Clark, A.W.; Coyle, J.T.; and DeLong, M.R. 1981. Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis. Ann. Neurol. 10 122–126.
Zamorano, L., and Chuaqui, B. 1979. Teratogenetic periods for the principal malformations of the central nervous system. Virchows Arch. A Path. Anat. Histol. 384: 1–18.
Zuppinger, K.; Wiesmann, U.; Siegrist, H.P.; Schafer, T.; Sandru, L.; Schwartz, H.P.; and Herschkowitz, N. 1981. Effect of glucose deprivation on sulfatide synthesis and oligodendrocytes in cultured brain cells of newborn mice. Pediatr. Res. 15: 319–325.
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© 1982 Dr. S. Bernhard, Dahlem Konferenzen, Berlin
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Herschkowitz, N.N., McKhann, G.M. (1982). Normal and Abnormal Development of the Human Nervous System. In: Nicholls, J.G. (eds) Repair and Regeneration of the Nervous System. Dahlem Workshop Reports, vol 24. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68632-0_3
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DOI: https://doi.org/10.1007/978-3-642-68632-0_3
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