A Synoptic View of the Development of the Vertebrate Central Nervous System
The rationale for a position paper on neural development at a conference devoted to “Repair and Regeneration of the Nervous System” is presumably to be found in the widely held, but as yet largely unsubstantiated, view that neural regeneration must recapitulate some, if not all, of the events in neurogenesis. But, in fact, if one excludes regeneration of portions of the neural plate or neural tube, which may lead to essentially complete restoration of the damaged tissue (6), what is usually implied by the terms “regeneration” and “repair” in the central nervous system relates to only two of the many events in neural development, namely, the formation and remodeling of neural connections (and to a lesser extent, to the proliferation, growth, and redeployment of glial cells). However, despite its possibly limited relevance, there is some merit in presenting a synoptic view of the entire sequence of vertebrate neurogenesis, if only to highlight the rather painful fact that the ultimate goal of promoting regeneration and reconstitution of damaged neural tissue remains a very distant prospect.
KeywordsMigration Retina Luminal Neurol Macromolecule
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- (4).Cowan, W.M. 1978. Aspects of neural development. In International Reviews of Physiology, ed. R. Porter, pp. 149–191. Baltimore, MD: University Park Press.Google Scholar
- (5).Cowan, W.M. 1979. Selection and control in neurogenesis. In The Neurosciences: Fourth Study Program, ed. F.O. Schmitt, pp. 59–79. Boston: M.I.T. Press.Google Scholar
- (6).Cowan, W.M., and Finger, T.E. 1981. Regeneration and regulation in the developing central nervous system with special reference to the reconstitution of the optic tectum of the chick following removal of the mesencephalic alar plate. In Neuronal Development, Current Topics in Neurobiology, ed. N.C. Spitzer, vol. 5. New York: Plenum Press, in press.Google Scholar
- (8).Jacobson, M. 1978. Developmental Neurobiology. New York: Plenum Press.Google Scholar
- (10).Oppenheim, R.W. 1981. Neuronal cell death and some related regressive phenomena during neurogenesis: a selective historical review and progress report. In Studies in Developmental Neurobiology, ed. W.M. Cowan, pp. 74–133. New York: Oxford University Press.Google Scholar
- (16).Sharma, S.C. 1981. Determination of central retinal connections. In Studies in Developmental Neurobiology, ed. W.M. Cowan, pp. 218–230. New York: Oxford University Press.Google Scholar
- (17).Spemann, H. 1938. Embryonic Development and Induction. New Haven: Yale University Press.Google Scholar