Abstract
Myocarditis means simply inflammation of the myocardium, and this is the best complete definition. Infections can of course cause myocarditis, but so can a variety of noninfectious diseases. Every focus of degeneration in the myocardium, whatever its etiology, is associated with some degree of inflammation. Furthermore, every such focus is normally eventually replaced with scar, so that after focal degeneration one must expect focal fibrosis. These are two principles fundamental to a comprehensive understanding of myocarditis: that virtually every form of myocardial degeneration is associated with some inflammation, and that degeneration inevitably ends in some degree of fibrosis.
This work was supported by the National Heart, Lung and Blood Institute (Program Project Grant HL 11310 and SCOR on Ischemic Heart Disease HL 17667) and by the Underwood Bequest for Cardiovascular Research
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James, T.N. (1983). Myocarditis and Cardiomyopathy: The Panoramic Nature of Their Etiology, Pathogenesis, and Clinical Consequences, with Special Consideration of the Involvement of the Conduction System. In: Just, H., Schuster, H.P. (eds) Myocarditis Cardiomyopathy. International Boehringer Mannheim Symposia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68608-5_4
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