Abstract
The introduction of myocardial biopsy by Konno and Sakakibara allowed the evaluation of a living patient’s myocardium [19]. The aims of the method include the histologic diagnosis of cardiomyopathy, the differentiation of various subgroups of the disease, and the possible role of myocarditis in its pathogenesis. Despite nearly 20 years experience and a considerable number of investigations there is still no agreement on the diagnostic or prognostic value of the technique, since it has failed to demonstrate specific morphological criteria in the different cardiomyopathies [12, 27, 28, 31, 32]. The purpose of the present study was to find out whether the various well-known changes in quality or quantity might be of any value for the clinical cardiologist.
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References
Baandrup U, Florio RA, Olsen EGJ (1982) Do endomyocardial biopsies represent the morphology of the rest of the myocardium? A quantitative light microscopic study of single and multiple biopsies with the King’s bioptome. Eur Heart J 3: 171–178
Baandrup U, Florio RA, Roters F, Olsen EGJ (1981) Electron microscopic investigation of endomyocardial biopsy samples in hypertrophy and cardio-myopathy. A semiquantitative study in 48 patients. Circulation 63: 1289–1298
Baandrup U, Florio RA, Rehan M, Richardson PJ, Olsen EGJ (1981) Critical analysis of endomyocardial biopsies from patients suspected of having cardiomyopathy. II. Comparison of histology and clinical hemodynamic information. Br Heart J 45: 487–493
Baandrup U, Olsen EGJ (1981) Critical analysis of endomyocardial biopsies from patients suspected of having cardiomyopathy. I. Morphological and morphometric aspects. Br Heart J 45: 475–486
Becker AE, Caruso G (1982) Myocardial disease. A critical review. Br Heart J 47: 527–538
Bolte HD (1978) Immunologic investigation in patients with cardiomyopathies. In: Kaltenbach M, Loogen F, Olsen EGJ (eds) Cardiomyopathy and myocardial biopsy. Springer, Berlin Heidelberg New York, pp 251–255
Bouhour JB, Petitier H, De Lajartre AY, Almazor M, Nicholas G, Horeau J (1976) La biopsie myocardique dans les myocardiopathies congestives en appearance primitives. Arch Mai Coeur 69: 485
Doerr W (1971) Morphologie der Myokarditis. Verh Dtsch Ges Inn Med 77: 301–335
Ferrans VJ (1977) Ultrastructure of degenerated muscle cells in patients with cardiac hypertrophy. In: Riecker G, Weber A, Goodwin J (eds) Myocardial failure. Springer, Berlin Heidelberg New York, pp 185–200
Ferrans VJ (1978) Myocardial ultrastructure in human cardiac hypertrophy. In: Kaltenbach M, Loogen F, Olsen EGJ (eds) Cardiomyopathy and myo-cardial biopsy. Springer, Berlin Heidelberg New York, pp 100–120
Ferrans VJ, Jones M, Maron BJ, Roberts WC (1975) The nuclear membranes in hypertrophied human cardiac muscle cells. Am J Pathol 78: 427–460
Ferrans VJ, Massumi RA, Shugoll GJ, Ali N, Roberts WD (1973) Ultra-structural studies of myocardial biopsies in 45 patients with obstructive or congestive cardiomyopathy. In: Bajusz E, Rona S, Brink AJ (eds) Recent advances in cardiac structure and metabolism. Cardiomyopathies. Universi-ty Press Baltimore, pp 231–272
Ferrans VJ, Morrow AG, Roberts WC (1972) Myocardial ultrastructure in idiopathic hypertrophic subaortic stenosis: A study of operatively excised left ventricular outflow tract muscle in 14 patients. Circulation 45: 769–791
Goodwin JF (1982) The frontiers of cardiomyopathy. Br Heart J 48: 1–18
Herman MV, Gorlin R, Kreulen T (1974) Ventriculographic classification of primary myocardial disease. In: Comparative pathology of the heart. Adv Cardiol 13: 53–67
Hess OM, Schneider J, Turina M, Heeb S, Grob P, Krayenbiihl HP (1977) Die transvenöse Endomyokardbiopsie in der Beurteilung der kongestiven Kardiomyopathie. Schweiz Med Wochenschr 107: 293–300
Jones M, Ferrans VJ, Morrow AG, Roberts WC (1975) Ultrastructure of cristal supraventricularis muscle in 37 patients with congenital heart disease associated with right ventricular outflow tract obstruction. Circulation 51: 39–68
Kawai C, Matsumori (1980) Myocardial biopsy. Am Rev Med 31: 139–157
Konno S, Sakakibara S (1963) Endomyocardial biopsy. Dis Chest 44: 345–350
Kuhn H, Breithard G, Knieriem HJ, Loogen F (1978) Endomyocardial catheter biopsy in heart disease of unknown etiology. In: Kaltenbach M, Loogen F, Olsen EGJ (eds) Cardiomyopathy and myocardial biopsy. Springer, Berlin Heidelberg New York, pp 121–137
Kuhn H, Breithard G, Knieriem HJ, Loogen F, Both A, Schmidt WAK, Strobandt R, Gleichmann U (1975) Die Bedeutung der endomyocardialen Katheterbiopsie für die Diagnostik und die Beurteilung der Prognose der kongestiven Kardiomyopathie. Dtsch Med Wochenschr 100: 717–723
Kuhn H, Knieriem HJ, Lösse B, Breithard C, Köhler E, Seipel L, Loogen F (1978) Prognosis and possible presymptomatic manifestations of con-gestive cardiomyopathy. Postgrad Med J 54: 451–459
Kunkel B, Lapp H, Kober G, Kaltenbach M (1978) Correlation between clinical and morphologic findings and natural history in congestive cardiomyopathy. In: Kaltenbach M, Loogen F, Olsen EGJ (eds) Cardiomyopathy and myocardial biopsy. Springer, Berlin Heidelberg New York, pp 271–283
Kunkel B, Schneider M, Hopf R, Kober G, Hübner K, Kaltenbach M (1982) Left ventricular biopsy in hypertrophic cardiomyopathy: Light and electron microscopic evaluations. In: Kaltenbach M, Epstein SE (eds) Hypertrophic cardiomyopathy. The therapeutic role of calcium-antagonists. Springer, Berlin Heidelberg New York, pp 58–69
Maisch B (1982) Herzmuskelantikörper bei Myokarditis. Med Klinik 77: 114–118
Maron BJ, Ferrans VJ, Henry WH, Clark CE, Redwood DR, Roberts WC, Morrow AG, Epstein S (1974) Differences in distribution of myocardial abnormalities in patients with obstructive and nonobstructive asymmetrical septal hypertrophy. Circulation 50: 436–446
Maron BJ, Ferrans VJ, Roberts WC (1975) Myocardial ultrastructure in patients with chronic aortic valve disease. Am J Cardiol 35: 725–739
Maron BJ, Ferrans VJ, Roberts WC (1975) Ultrastructural features of de-generated cardiac muscle cells in patients with cardiac hypertrophy. Am J Pathol 79: 387–434
Maron BJ, Roberts WC (1982) Distribution and significance of cardiac muscle cell disorganisation in the left ventricle of patients with hyper-trophic cardiomyopathy: Evidence of a diffuse cardiomyopathic process. In: Kaltenbach M, Epstein SE (eds) Hypertrophic cardiomyopathy. The therapeutic role of calcium-antagonists. Springer, Berlin Heidelberg New York, pp 38–52
Mason JW, Billingham ME, Ricci DR (1980) Treatment of acute inflammatory myocarditis assisted by endomyocardial biopsy. Am J Cardiol 45: 1037–1044
Olsen EGJ (1978) Postmortem findings and histologic, histochemical, and electron microscopic findings in myocardial biopsies. In: Kaltenbach M, Loogen F, Olsen EGJ (eds) Cardiomyopathy and myocardial biopsy. Springer, Berlin Heidelberg New York, pp 52–61
Olsen EGJ (1978) Special investigation of COCM. Endomyocardial biopsies (morphological analysis). Postgrad Med J 54: 486–490
Richardson PJ, Livesly B, Oram S, Olsen EGJ, Armstrong P (1974) Angina pectoris with normal coronary arteries. Transvenous myocardial biopsy in diagnosis. Lancet 11: 677–680
Roberts WC, Ferrans VJ, Buja LM (1974) Pathologic aspects of the idiopathic cardiomyopathies. In: Comparative pathology of the heart. Adv Cardiol 13: 349–667
Schwarz F, Schaper J, Kittstein D, Flameng W, Walter P, Schaper W (1981) Reduced volume fraction of myofibrils in myocardium with decompensated pressure overload. Circulation 63: 1229–1304
Segikuchi M, Haze K, Hiroe M, Konno S, Hirosawa K (1978) Interrelation of left ventricular function and myocardial ultrastructure as assessed by endomyocardial biopsy. Comparative study of hypertrophic and congestive cardiomyopathies. In: Kobayashi T, Ilo Y, Rona G (eds) Recent Advances in studies on cardiac structure and metabolism, vol 12, Cardiac adaption. University Park Press, Baltimore, pp 327–334
Segikuchi M, Hiroe M, Morimoto S, Kawagoe Y (1978) The contribution of endomyocardial biopsy to the diagnosis and assessment of cardiomyo-pathies. In: Hayase S, Murao S (eds) Proceedings of the VIII. World Congress of Cardiology, pp 583–590
Van Norden S, Olsen EGJ, Pearse AGE (1971) Hypertrophic obstructive cardiomyopathy, a histological, histochemical, and ultrastructural study of biopsy material. Cardiovasc Res 5: 118–131
Weibel E, Kistler GS, Scherle WF (1966) Practical stereological methods for morphometric cytology. J Cell Biol 30: 23–38
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Kunkel, B., Schneider, M., Hübner, K., Kaltenbach, M. (1983). The Clinical Significance of Myocardial Biopsy. In: Just, H., Schuster, H.P. (eds) Myocarditis Cardiomyopathy. International Boehringer Mannheim Symposia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68608-5_11
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DOI: https://doi.org/10.1007/978-3-642-68608-5_11
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