Abstract
Compensatory stimulation of vasoconstrictor systems may contribute to the rise in systemic vascular resistance observed in patients with heart failure (1). Because the elevation of peripheral resistance may further depress left ventricular function, vasodilators have been used to counteract this vasoconstriction and to improve cardiac performance (2–4). This study examines the effects of isosorbide dinitrate and/or hydralazine on the activity of the sympathetic nervous system, on the renin — angiotensin system, and on vasopressin release in patients with congestive heart failure. In particular, we have assessed whether increased activity of these vasoconstrictor systems may limit the drug-mediated effects in these patients.
Supported by the Deutsche Forschungsgemeinschaft, SFB 90 (Kardiovaskuläres System) Heidelberg, Federal Republic of Germany
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References
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© 1983 Springer-Verlag Berlin Heidelberg
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Manthey, J. et al. (1983). Effects of Hydralazine and Isosorbide Dinitrate on Vasoconstrictor Mechanisms in Patients with Heart Failure. In: Just, H., Bussmann, WD. (eds) Vasodilators in Chronic Heart Failure. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68605-4_7
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DOI: https://doi.org/10.1007/978-3-642-68605-4_7
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-68607-8
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