Abstract
The influence of the renal sympathetic nerves on kidney function has been a subject of controversy since Bernard (1859) observed that acute section of the splanchnic nerves in the anesthetized dog results in an increase in urine production by the ipsilateral kidney. This controversy centers around two questions:
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1.
Is the “denervation diuresis” exclusively hemodynamic in origin due to the increase of renal blood flow and glomerular filtration rate, or is there also an effect of the renal nerves on the tubular mechanism of reabsorption?
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2.
Is the phenomenon of denervation diuresis evident only under the artificial circumstances of anesthesia and surgical trauma and therefore not of functional significance?
This study was supported by the Deutsche Forschungsgemeinschaft, S.F.B. 90 (Kardiovaskuläres System), Heidelberg, Federal Republic of Germany
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Kirchheim, H. (1983). Regulation of Renal Hemodynamics in Congestive Heart Failure. In: Just, H., Bussmann, WD. (eds) Vasodilators in Chronic Heart Failure. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68605-4_4
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DOI: https://doi.org/10.1007/978-3-642-68605-4_4
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