Efficacy of AR-L 115 BS on Hemodynamics, Contractility, and Myocardial Oxygen Consumption in Man

  • M. Oeff
  • R. Schröder


In search of new drugs with positive isotropic and vasodilatory effects for treating chronic congestive heart failure, the imidazole derivative AR-L 115 BS (2-[(2-methoxy-4-methylsulfinyl)-phenyl]-1H-imidazo [4, 5-b]pyridine) was developed. It combines the following effects: high direct cardiac efficacy, a distinctly higher therapeutic range than digitalis glycosides, no substantial increase in the heart rate, long biological half life, and good intestinal reabsorption.


Mean Arterial Pressure Myocardial Oxygen Consumption Chronic Congestive Heart Failure Right Atrial Pressure Digitalis Glycoside 
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© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • M. Oeff
  • R. Schröder

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