Summary
In order to determine the acute hemodynamic effect of nifedipine at rest and during a standardized supine bicycle exercise test (3 min, 50 W),14 patients with left ventricular dysfunction due to coronary artery disease (ten) and congestive cardiomyopathy (four) were studied before and 60 min after taking 30 mg nifedipine sublingually.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Mcllwraith GR, Kidner PH, Oram S (1980) Effect of Nifedipine on exercise tolerance in angina pectoris. Br Heart J 44: 335
Moshowitz RM, Piccini RA, Nacarelli GV, Zelis R (1979) Nifedipine therapy for stable angina pectoris. Preliminary results of effects on angina frequency and treadmill exercise response. Am J Cardiol 44: 811
Previtali M, Salerno JA, Tavazzi R, Ray M, Medici A, Chimienti M, Specchia G, Bobber P (1980) Treatment of angina at rest with nifedipine: a short term controlled study. Am J Cardiol 45: 825
Engel HJ, Wolf R, Handeshagen H, Lichtlen PR (1980) Different effects of nitroglycerin and nifedipine on regional myocardial blood flow during pacing induced angina pectoris. Eur Heart J [Suppl Bj 1: 53
Henry PD, Schuchleib R, Clark RE, Perez JE (1979) Effect of nifedipine on myocardial ischemia: analysis of collateral flow, pulsatile heart and regional muscle shortening. Am J Cardiol 44: 817
Vater W, Schlossmann K (1976) Effects of nifedipine on the hemodynamics and the oxygen consumption of the heart in animal experiments. In: Jatene AD, Lichtlen PR (eds) Proc of the 3rd international Adalat symposium. Exerpta medica, Amsterdam, p 33
Clark RE, Christlieb IY, Henry PD, Fischer AE, Nora JD, Williamson JR, Sobel BE (1979) Nifedipine: a myocardial protective agent. Am J Cardiol 44: 825
Selwyn AP, Welman FK, Fox K, Morlock P, Pratt T, Klein M (1979) The effects of nifedipine on acute experimental myocardial ischemia and infarction in dogs. On Res 44: 16
Nayler WG (1980) The pharmacological protection of the ischemic heart, the use of calcium and beta-adrenoceptors antagonists. Eur Heart J [Suppl B] 1: 5
Beck OA, Wolf R, Hochrein H (1977) Die hämodynamische Wirkung von Nifedipin bei kompensierten and dekompensierten Koronarkranken. Munch Med Wochenschr 119: 39
Klugmann S, Salvi A, Camerini F (1980) Hemodynamic effects of nifedipine in heart failure. Br Heart J 43: 440
Kaufmann L (1977) Differenzierung verschiedener Kalziumantagonisten. Munch Med Wochenschr 119: 6
Verdouw PD, Ten Cate FJ, Hugenholtz P (1980) Effect of nifedipine on segmental myocardial function in the anesthetized pig. Eur J Cardiol 63: 209
Matsumoto S, Ito T, Sada T, Tahahashi M, Su K, Ueda A, Okata F, Sato M, Sekine J, Ito Y (1980) Hemodynamic effects of nifedipine in congestive heart-failure. Am J Cardiol 46: 476
Chatterjee K, Parmley WW, Massie B, Greenberg B, Wiener J, Klausen S, Norman A (1976) Oral hydralazine therapy for chronic refractery heart failure. Circulation 54: 879
Mostbeck A, Partsch H, Peschel L (1976) Investigations on peripheral blood distribution. In: Jatene AD, Lichtlen PR (eds) 3rd international Adalat symposium. New therapy of ischemic heart disease. Exerpta medica, Amsterdam, p 91
Lichtlen PR, Engel HJ, Amende J, Rafflenbeul W, Simon R (1976) Mechanisms of various anti-anginal drugs. Relationship between regional flow behaviour and contractility. In: Jatene AD, Lichtlen PR (eds) 3rd international Adalat symposium. Exerpta Medica, Amsterdam, p 14
Henry PD, Schuchleib R, Davis J, Weiss ES, Sobel BE (1977) Myocardial contracture and accumulation of mitochondrial calcium in ischemic rabbit heart. Am J Physiol 233: H677
Lorell BH, Turi Z, Grossman W (1980) Modification of left ventricular response to pacing tachycardia by nifedipine in patients with coronary artery disease (Abstr) Circulation 62II: 992
Hanrath P, Kremer P, Bleifeld W (1982) Influence of nifedipine on left ventricular dysfunction at rest and during exercise. Eur Heart J 3
Polese et al. (1979) Am J Med 30: 825
Klugmann et al. (1980) Eur Heart J [Suppl] 1: 49
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1983 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Hanrath, P., Kremer, P. (1983). Acute Effect of Nifedipine on Left Ventricular Performance at Rest and During Exercise in Patients with Left Ventricular Dysfunction. In: Just, H., Bussmann, WD. (eds) Vasodilators in Chronic Heart Failure. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68605-4_18
Download citation
DOI: https://doi.org/10.1007/978-3-642-68605-4_18
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-68607-8
Online ISBN: 978-3-642-68605-4
eBook Packages: Springer Book Archive