Skip to main content

The Long-Term Effects of Dihydralazine and Hydralazine on Intractable Cardiac Failure

  • Chapter
Vasodilators in Chronic Heart Failure

Abstract

The object of this work was to study the long-term effects of the hydrazinophthalazines [hydralazine (Apresoline) or dihydralazine (Nepresol)] using our own clinical studies (38 patients treated with dihydralazine) and a review of the literature. Their short-term effects are well known but there is less information available on their long-term effects (2, 8). It is generally accepted that the pharmacological effects of the two commercially available hydrazinophthalazines are very similar.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Boxenbaum HG, Riegelman S (1974) Determination of isoniazide and metabolites in biological fluides. J Pharm Sci 63: 1191

    Article  PubMed  CAS  Google Scholar 

  2. Chatterjee K, Parmley WW, Massie B, Greenberg B, Werner J, Klausner S, Norman A (1976) Oral hydralazine therapy for chronic refractory heart failure. Circulation 54: 879

    PubMed  CAS  Google Scholar 

  3. Convert G (1978) Etude prognostique des cardiomyopathies primitives non obstructives. Med Dissertation, Lyon University

    Google Scholar 

  4. Eitchett DH, Marin Neto JA, Oakley CM, Goodwin JF (1979) Hydralazine in the management of left ventricular failure. Am J Cardiol 44: 303–309

    Article  Google Scholar 

  5. Massie B, Ports T, Chatterjee K, Parmley W, Ostland J, O’Young J, Haughom F (1981) Longterm vasodilator therapy for heart failure: clinical response and its relationship to hemodynamic measurements. Circulation 63: 269–278

    Article  PubMed  CAS  Google Scholar 

  6. Massie B, Kramer B, Gaughom F (1981) Postural hypotension and tachycardia during hydralazine-isosorbide dinitrate therapy for chronic heart failure. Circulation 63: 658–664

    Article  PubMed  CAS  Google Scholar 

  7. Mathey DM, Hanrath P, Polste J, Witte G, Montz R, Bleifield W (1981) Short term and long term effects of oral hydralazine on left ventricular pump function and renal haemodynamics in chronic left heart failure. In: Rutishauser W (ed) The place of vasodilators in the long-term treatment of intractable heart failure. Hans Huber, Bern Stuttgart Vienna

    Google Scholar 

  8. Morand P, Lavigne G, Masson D, Latour F, Alison D (1979) Traitement de l’insuffisance cardiaque chronique sévère par la dihydralazine. Arch Mal Coeur 3: 268

    Google Scholar 

  9. Packer M, Meller J, Medina N, Gorlin R, Herman MV (1980) Dose requirements of hydralazine in patients with severe chronic congestive heart failure. Am J Cardiol 45: 655

    Article  PubMed  CAS  Google Scholar 

  10. Perry HM (1973) Late toxicity to hydralazine ressembling systemic lupus erythematosus or rheumatoid arthritis. Am J Med 54: 56

    Google Scholar 

  11. Wechsler B, Brion NO, Colan C, Ximines H, Godeau P (1979) Lupus érythémateux induit par la dihydralazine. Nouv Presse Méd 45: 8

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1983 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Morand, P., Lavigne, G. (1983). The Long-Term Effects of Dihydralazine and Hydralazine on Intractable Cardiac Failure. In: Just, H., Bussmann, WD. (eds) Vasodilators in Chronic Heart Failure. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68605-4_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-68605-4_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-68607-8

  • Online ISBN: 978-3-642-68605-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics