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Nitrates in Chronic Heart Failure

  • Wulf-Dirk Bussmann

Abstract

Nitrates are excellent agents in the treatment of acute heart failure. Striking clinical and hemodynamic improvement can be achieved in acute pulmonary edema, left heart failure during the acute phase of myocardial infarction, papillary muscle syndrome or rupture of the interventricular septum, hypertensive crisis concomitant with heart failure, and certain types of cardiogenic shock. Isosorbide dinitrate and nitroglycerin have been investigated extensively. Their actions will be reviewed briefly.

Keywords

Chronic Heart Failure Pulmonary Artery Pressure Pulmonary Artery Systolic Pressure Left Ventricular Filling Pressure Isosorbide Dinitrate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Becker HJ, Walden G, Kaltenbach M (1976) Gibt es eine Tachyphylaxie, beziehungsweise Gewöhnung bei der Behandlung der Angina pectoris mit Nitrokörpern. Verh Dtsch Ges Inn Med 82: 1208–1210PubMedGoogle Scholar
  2. Bussmann W-D, Lemke R, Kaltenbach M (1981) Chronic isosorbide dinitrate for treatment of refractory heart failure. In: Just H, Bussmann W-D (eds) Therapie der chronischen Herzinsuffizienz mit Vasodilatantien. Verlag edition medizin, Weinheim Derrfield Beach Basel, pp 10–14Google Scholar
  3. Franciosa JA, Nordstrom LA, Cohn JN (1978) Nitrate therapy for congestive heart failure. JAMA 240: 433–446CrossRefGoogle Scholar
  4. Franciosa JA, Cohn JN (1980) Substained hemodynamic effects without tolerance during longterm isosorbide dinitrate treatment of chronic left ventricular failure. Am J Cardiol 45:648–654PubMedCrossRefGoogle Scholar
  5. Lemke R, Lippok R, Kaltenbach M, Bussmann W-D (1978, 1979 ) Orale Langzeitbehandlung der chronischen Linksherzinsuffizienz mit Isosorbiddinitrat und Phentolamin. Z Kardiol [Suppl] 5:16, Z Kardiol 68: 82–88Google Scholar
  6. Massie B, Ports T, Chatterjee K, Parmley W, Ostland J, O’Young BS, Haughom F (1981) Longterm vasodilator therapy for heart failure: clinical response and its relationship to hemodynamic measurements. Circulation 63: 269–278PubMedCrossRefGoogle Scholar
  7. Schafer AI, Laxeander RW, Handin RI (1980) Inhibition of platelet function by organic nitrate vasodilators. Blood 55: 649–654PubMedGoogle Scholar
  8. Schneider W, Stahl B, Kaltenbach M, Bussmann W-D (1981) Dosis-Wirkungsbeziehungen bei der Behandlung der koronaren Herzkrankheit mit Isosorbiddinitrat ( Abstr ). Z Kardiol 70: 321Google Scholar
  9. Thadani U, Manyari D, Parker JO, Fung H (1980) Tolerance to the circulatory effects of oral isosorbide dinitrate. Circulation 61: 526–535Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • Wulf-Dirk Bussmann

There are no affiliations available

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