Abstract
Previous studies have demonstrated the presence of IgE class-specific helper and suppressor T cells which show a regulatory effect only on the IgE antibody response (1,2,3). Thus, T cells from mice primed with hapten (DNP or PC)2)-coupled mycobacterium showed the selective suppressive effect on the in vivo as well as in vitro IgE responses against DNP-antigen or PC-antigen, respectively (2,4,5). The suppressor function was shown to be mediated by antigen-nonspecific, IgE class-specific suppressor factor(s) (IgE-TsF) released from DNP- or PC- mycobacterium (Myc)-primed T cells by antigen-specific stimulation. IgE-TsF had neither Ig determinants nor antigen binding sites (4), but bore the I region gene products (6). Furthermore, IgE-TsF has been proved to have the binding site(s) for IgE molecules as well as I region gene products on the same molecules (7). In the present experiment, we have established IgE class-specific suppressor T hybridomas and studied the function and properties of IgE specific suppressor factors obtained from them.
This work was supported by a grant from the Ministry of Education, Science and Culture, Japan.
Abbreviations used in this paper: DNP, 2.4-dinitrophenyl; PC, phosphorylcholine; Myc, Mycobacterium tuberculosis.
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References
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© 1982 Springer-Verlag Berlin Heidelberg
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Suemura, M. et al. (1982). Regulation of the IgE Response by IgE Class-Specific Suppressor T Hybridomas. In: Boehmer, H.V., Haas, W., Köhler, G., Melchers, F., Zeuthen, J. (eds) T Cell Hybridomas. Current Topics in Microbiology and Immunology, vol 100. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68586-6_9
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DOI: https://doi.org/10.1007/978-3-642-68586-6_9
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