Abstract
An antigen-specific suppression of antibody response has been known to be mediated by the factor derived from suppressor T cells (Ts). An antigen-specific suppressor T cell factor (TsF) has been found to possess the antigen-binding moiety and the products of genes in the I-J subregion of the H-2 complex (1). No known constant region determinant of the conventional immunoglobulins (Igs) has been found on suppressor T cells and their factors. It is, however, reported that TsF carries the structure analogous to the variable region of the Ig heavy chain (Igh) (1,2). Therefore, at least two gene products may be involved in the structural entity of the antigen-specific TsF: one encoded by genes in the I-J subregion and the other by genes analogous or identical to the Igh-V genes.
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References
Taniguchi M, Saito T, Takei I, Kanno M, Tokuhisa T, Tomioka H (1981) Suppressor T cell hybridomas and their soluble products. In: Pick E (ed) Lymphokines, Vol. 15. Academic Press, New York, p 77
Tada T, Hayakawa K, Okumura K, Taniguchi M (1980) Coexistence of the variable region of immunoglobulin heavy-chain and I-region gene products on antigen-specific suppressor T cells and suppressor T cell factors — a minimal model of a functional antigen receptor of T cells. Mol Immunol 17: 867
Kontiainen S, Simpson E, Bohrer E, Beverley PCL, Herzenberg LA, Fitzpatrick WC, Vogt P, Torano A, McKenzie IFC, Feldmann M (1978) Hybrid cell lines with T-cell characteristics. Nature 274: 477
Taussig M, Covalan JRF, Binns RM, Holliman A (1979) Production of an H-2-related suppressor factor by a hybrid T cell line. Nature 277: 305
Taniguchi M, Saito T, Tada T (1979) Antigen-specific suppressive factor produced by a transplantable I-J-bearing T cell hybridoma. Nature 278: 555
Okuda K, Minami M, Ju ST, Dorf ME (1981) Functional association of idiotypic and I-J determinants on the antigen receptor of suppressor T cells. Proc Natl Acad Sci USA 78: 4557
Taniguchi M, Takei I, Tada T (1980) Functional and molecular organization of an antigen-specific suppresor factor derived from a T cell hybridoma. Nature 283: 227
Taniguchi M, Saito T, Takei I, Tokuhisa T (1981) Presence of interchain disulfide bonds between two gene products that compose the secreted form of an antigen-specific suppressor factor. J Exp Med 153: 167 2
Tokuhisa T, Taniguchi M (1982) Two distinct allotypic determinants on the antigen-specific suppressor and enhancing T cell factors that are encoded by genes linked to the immunoglobulin heavy-chain locus. J Exp Med, in press
Tokuhisa T, Taniguchi M (1982) Constant region determinants on the antigen-binding chain of the antigen-specific suppressor T cell factor. Submitted for publication.
Tokuhisa T, Komatsu S, Uchida Y, Taniguchi M (1982) Monclonal antibodies specific for the constant region of the T cell antigen receptors. Submitted for publication.
Owen FL, Riblet R, Taylor BA (1981) The suppressor cell alloantigen Tsud maps near immunoglobulin allotype genes and may be a heavy-chain constant-region marker on a T cell receptor. J Exp Med 153: 801
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Taniguchi, M., Tokuhisa, T., Kanno, M., Honjo, T. (1982). An Antigen-Specific Suppressor T Cell Factor Controlled by Two Genes in the Immunoglobulin Heavy Chain Linkage Group and in the I-J Subregion of the H-2 Complex. In: Boehmer, H.V., Haas, W., Köhler, G., Melchers, F., Zeuthen, J. (eds) T Cell Hybridomas. Current Topics in Microbiology and Immunology, vol 100. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68586-6_4
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DOI: https://doi.org/10.1007/978-3-642-68586-6_4
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