Abstract
The major toxic effect of aminoglycosides is nephrotoxicity. In general, aminoglycosides are not metabolized in vivo, but are excreted by glomerular filtration. However, a portion can be reabsorbed via the proximal tubules and remain in the kidney, a process which may induce nephrotoxicity due to the damage of the tubules. Clinical pharmacologists have studied the detection of the early signs of nephrotoxicity and have searched for drugs which will alleviate nephrotoxicity.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Adams HR (1973) Neuromuscular blocking effect of aminoglycoside antibiotic in nonhuman primate. J Am Vet Med Assoc 163:613–616
Adams HR, Goodman FR, Weiss GB (1974) Alteration of contractile function and calcium ion movements in vascular smooth muscle by gentamicin and other aminoglycoside antibiotics. Antimicrob Agents Chemother 5:640–646
Akiyoshi M (1979) Inner ear damage, its evaluation and safety administration of ototoxic aminoglycoside antibiotics, innermost row of the outer hair cells. Clin Bacteriol 6:353–361
Akiyoshi M, Sato K (1967 a) Histopathological and enzyme histochemical studies on ototoxicity due to gentamicin and kanamycin in guinea pigs. Chemotherapy (Tokyo) 15:501–512
Akiyoshi M, Sato K (1967 b) Histochemical demonstration of succinic dehydrogenase activity of the hair cells by means of intravital perfusion of the cochlea. Audiology Jpn 10:48–56
Akiyoshi M, Sato K (1968) Functional, histopathological and histochemical studies on the ototoxicity in guinea pigs due to aminosidine. Chemotherapy (Tokyo) 16:134–138
Akiyoshi M, Sato K (1969 a) Experimental study on the ototoxicity of aminodeoxykanamy- cin in guinea pig, pinna reflex and histopathologic findings. Chemotherapy (Tokyo) 17:1656–1663
Akiyoshi M, Sato K (1969 b) Réévaluation of the pinna reflex test as screening for ototoxicity of antibiotics. Prog Antimicrob Anticancer Chemother. University of Tokyo Press, vol 1, pp 621–627
Akiyoshi M, Sato K (1971) Ototoxicity of vistamycin. Audiology Jpn 14:189–201
Akiyoshi M, Sato K (1973) Histochemical study of reduction potency of ubiquinone of hairn cells of the spiral organ in guinea pigs. Acta Histochem Cytochem 233–247
Akiyoshi M, Sato K, Sugahiro K, Shoji T (1968) Functional, histochemical and istopathological studies on ototoxicity of enduracidin in guinea pigs. Chemotherapy (Tokyo) 16:511–520
Akiyoshi M, Sato K, Tamura H (1972) Ototoxicity of liviodomycin. Audiology Jpn 15:220–223
Akiyoshi M, Sato K, Nakada H, Tojima T (1974 a) Audiometrical and histopathological evaluation of ototoxicity of 3’,4’-dideoxykanamycin B (DKB), a new semisynthetic aminoglycoside antibiotic in guinea pigs. Jpn J Antibiot 27:15–26
Akiyoshi M, Sato K, Shoji T, Sugahiro K, Tajima T, Koeda T, Odaki M, Yokata M (1974 b) Ototoxic effect of 3’,4’-dideoxykanamycin B on the inner ear in the intrauterine guinea pigs. Jpn J Antibiot 27:735–745
Akiyoshi M, Sato K, Nakada H, Nara T, Tajima T, Sasaki K, Ogawa M (1975 a) Ototoxicity of tobramycin in guinea pigs. Chemotherapy (Tokyo) 23:1522–1543
Akiyoshi M, Sato K, Nakada H, Tajima T, Suzuki K, Kishimoto K (1975 b) Evaluation of ototoxicity of amikacin (BB-K8) by animal test. Jpn J Antibiot 28:288–304
Akiyoshi M, Iwazawa T, Yano S, Shoji T, Tajima T, Hara T, Shimizu M (1977) Animal test for evaluation of ototoxicity and safety of KW-1062. Chemotherapy (Tokyo) 25:1892–1914
Albiero L, Ongini E, Parravicini L (1978) The neuromuscular blocking activity of a new aminoglycoside antibiotic netilmicin sulphate. Eur J Pharmacol 50:1–7
Alleva FR, Balzas T (1978) Toxic effects of potential administration of streptomycin sulfate to rats. Toxicol Appl Pharmacol 45:855–859
Anhalt JP (1977) Assay of gentamicin in serum by highpressure liquid chromatography. Antimicrob Agents Chemother 11:651–655
Aratani H, Yamanaka Y, Onishi R, Kono S, Hashimoto T, Hirozane T (1968) Pharmacological studies on amidosidine. Chemotherapy (Tokyo) 6:114–120
Asakuma S, Shida S, Suzuki M, Abe N (1975) Experimental study on the mutual relation between endocochlea DC potential and cochlear microphonics. Audiology Jpn 18:246–254
Barza M, Brown RB, Shen D, Gibaldi M, Weinstein L (1974) Predictability of blood levels of gentamicin in man. Clin Res 22:687A
Boger WP, Gavin JJ (1958–1959) Kanamycin: its cerebrospinal fluid diffusion, renal clearance and comparison with streptomycin. Antibiot Annu 676–677
Brazil OV, Corrado AP (1957) The curariform action of streptomycin. J Pharmacol Exp Ther 120:452–459
Brazil OV, Prado-Franceschi J (1969) The neuromuscular blocking action of gentamicin. Arch Int Pharmacodyn Ther 179:65–76
Broughall JM, Reeves DS (1975 a) Properties of the gentamicin acetyltransferase enzyme and application to the assay of aminoglycoside antibiotics. Antimicrob Agents Chemother 8:222–223
Broughall JM, Reeves DS (1975 b) The acetyltransferase enzyme method for the assay of serum gentamicin concentrations and a comparison with other methods. J Clin Pathol 28:140–145
Broughton A, Strong JE, Pickering LK, Bodey GP (1976 a) Radioimmunoassay of io-dinated tobramycin. Antimicrob Agents Chemother 10:652–656
Broughton A, Strong JE, Bodey GP (1976 b) Radioimmunoassay of sisomicin. Antimicrob Agents Chemother 9:247–250
Brown RD, Feldman AM (1978) Pharmacology of hearing and ototoxicity. Annu Rev Pharmacol Toxicol 18:233–252
Barza M, Brown RB, Shen D, Gibaldi M, Weinstein L (1975) Predictability of blood levels of gentamicin in man. J Infect Dis 132:165–174
Benzi G, Arrigoni E, Pancer P, Berte F (1972) Action on gentamicin, aminosidine, and am-picillin on uterine tone and motility. Jpn J Pharmacol 22:571–576
Berg K (1951) The toxic effect of streptomycin on the vestibular and cochlear apparatus.Acta Otolaryngo [Suppl] (Stockh) 97:1–47
Bergeron MG, Trottier S (1979) Influence of single or multiple doses of gentamicin and netilmicin on their cortical, medullary and papillary distribution. Antimicrob Agents Chemother 15:635–641
Berggärd I, Beam AG (1968) Isolation and properties of low molecular weight ß2-microglo- bulin occurring in human biological fluids. J Biol Chem 243:4095–4103
Bernard B, Abate M, Thielen PF, Attar H, Ballard CA, Wehrle PF (1977) Maternal-fetal pharmacological activity of amikacin. J Infect Dis 135:925–932
Bodey GP, Valdivieso M, Feld R, Rodriguez V (1974) Pharmacology of amikacin in humans. Antimicrob Agents Chemother 5:508–512
Brummett RE (1972) A comparative study of the ototoxicity of tobramycin and gentamicin. Arch Otolaryngol 96:505–512
Brummett RE, Traynor J, Brown R, Himes D (1975) Cochlear damage resulting from kanamycin and furosomide. Acta Otolaryngol (Stockh) 80:86–92
Cabana BE, Taggart JG (1973) Comparative pharmacokinetics of BB-K8 and kanamycinin dogs and humans. Antimicrob Agents Chemother 3:478–483
Chauvin JM, Rudhardt M, Bluauchard P, Gaillard R, Fabre J (1978) Le compartment de la gentamicine dans le parenckyme renal. Schweiz Med Wochenschr 108:1020–1025
Child KJ, Davis B, Sharpe HM, Tomich EG (1956–1957) Toxicologic studies on the sulfate and pantothenates of streptomycin and dihydrostreptomycin. Antibiot Annu 574–580
Chiu PJS, Long JF (1978) Effects of hydration on gentamicin excretion and renal accumulation in furosemide-treated rats. Antimicrob Agents Chemother 14:214–217
Chiu PJS, Brown A, Miller G, Long JF (1976) Renal extraction of gentamicin in anesthetized dogs. Antimicrob Agents Chemother 10:277–282
Chiu PJS, Miller GH, Brown AD, Long JF, Waitz JA (1977) Renal pharmacology of netilimicin. Antimicrob Agents Chemother 11:821–825
Collier VU, Mitch WE, Lietman PS (1978) Tubular uptake of gentamicin by the intact kidney. Clin Res 26:288A
Crawford LM, Bowen JM (1971) Calcium binding as a property of kanamycin. Am J Vet Res 32:357–359
Danish M, Schultz R, Jusco J (1974) Pharmacokinetics of gentamicin and kanamycin during hemodialysis. Antimicrob Agents Chemother 6:841–847
Daschner F, Reiss E, Engert J (1977) Distribution of amikacin in serum, muscle and fat in children after a single intramuscular injection. Antimicrob Agents Chemother 11:1081- 1083
Davis WW, Stout TR (1971) Disk plate method of microbiological antibiotic assay II, novel procedure offering improved accuracy. Appl Microbiol 22:666–670
Dellinger P, Murphy T, Barza M, Pinn V, Weinstein L (1976) Effect of cephalothin on renal cortical concentration of gentamicin in rats. Antimicrob Agents Chemother 9:587–588
Dettli L (1971) Multiple dose kinetics and drug dosage in patients with kidney disease. Acta Pharmacol Toxicol 29:211
Edwards CQ, Smith CR, Baugman KL, Rogers JF, Lietman PS (1976) Concentration of gentamicin and amikacin in human kidneys. Antimicrob Agents Chemother 9:925–927
Engström H, Kohonen A (1965) Cochlear damage from ototoxic antibiotics. Acta Otolaryngol (Stockh) 59:171–178
Ervin FR, Bullock WE Jr, Nuttal CE (1976) Inactivation of gentamicin by penicillins in patients with renal failure. Antimicrob Agents Chemother 9:1004–1011
Ezer J, Mahon WA, Inaba T (1976) Tissue distribution and selective kidney uptake of triti-ated aminoglycosides in the rats. Pharmacologist 18:206
Fujisawa K, Hoshiya T, Kawaguchi H (1974) Aminoglycoside antibiotics. VII. Acute toxicity of aminoglycoside antibiotics. J Antibiot (Tokyo) 27:677–681
Fujita M, Fukushima K, Abe M, Tomono N, Umemura K (1973) Experimental studies on absorption, excretion, distribution, and metabolism of 3’4’-dideoxy kanamycin B. II. Absorption, excretion, and distribution in rabbits and dogs. Jpn J Antibiot 26:55–60
Fukushima K, Fujita M (1970) Teratological study of vistamicin. Clin Rep 4:52–61
Furuno K, Andoh K, Suzuki S (1976 a) Effect of D-glucarates on basic antibiotic-induced renal damage in rats. J Antibiot (Tokyo) 29:187–194
Furuno K, Matsubara S, Andoh K, Suzuki S (1976 b) Preventive effect of D-glucarate against renal damage induced by kanamycin. J Antibiot (Tokyo) 29:950–953
Furuno K, Suzuki S, Hirata K (1977) Influence of dehydration and D-glucarate on distribution and excretion of kanamycin in rats. Jpn J Pharmacol 27:371–378
Garrod LP, Gruenwaldt G, Marget W, Wellta H (1979) New aspects of aminoglycoside therapy, sisomicin. Infection 7:294–300
Gergis SD, Dretchen KL, Sokoll MD, Long JP (1971) The effects of neuromuscular blocking agents on acetylcholine release. Proc Soc Exp Biol Med 38:693–695
Goodman FR (1978) Distribution of gentamicin in vascular smooth muscle. Pharmacology 16:17–25
Gordon RC, Regamey C, Kirby WMM (1972) Serum protein binding of the aminoglycoside antibiotics. Antimicrob Agents Chemother 2:214–216
Haas MJ, Davis J (1973) Enzymatic acetylation as a means of determining serum aminoglycoside concentrations. Antimicrob Agents Chemother 4:497–499
Hara T, Nishikawa S, Miyazaki H, Ohguro Y (1980) Studies on the safety of KW-1062 (Fifth report), a comparative study on the renal toxicity of KW-1062 and gentamicin in rats by light and electron microscopies. Jpn J Antibiot 33:1–9
Harada Y, Mori S, Teshima K, Ino M, Nakatani Y, Hirota K, Ishikawa M, Toyota H, Kawase M, Matsumura S, Kimoto S, Uno O, Nakao T (1975) Subacute toxicologic studies with tobramycin and its recovery studies in beagle dogs. Chemotherapy 23:1494–1521
Hasegawa Y, Yoshida T, Kozen T, Yamagata H, Sakaguchi I, Okamoto A, Ohara T, Kozen T (1975) Teratological studies on tobramycin in mice and rats. Chemotherapy 23:1544–1553
Hashimoto T, Ichikawa S, Kojima T (1977) The general pharmacological action of KW-1062, a new aminoglycoside antibiotics. Jpn J Antibiot 30:362–385
Hawkins JE Jr (1959) The ototoxicity of kanamycin. Ann Otol Rhinol Laryngol 68:698–715
Hawkins JE Jr, Arbor A (1976) Drug ototoxicity. In: Kiedel WD, Neff WD (eds) Auditory system. Clinical and special topics. Springer, Berlin Heidelberg New York (Handbook of sensory physiology, vol 5/3, pp 707–748)
Hawkins JE Jr, Engstrom H (1964) Effects of kanamycin on cochlear cytoarchitecture. Acta Otol Laryngol [Suppl] (Stockh) 188:100–107
Hawkins JE Jr, Wolcott H, O’Skanny WJ (1956–1957) Ototoxic effects of streptomycin and dihydrostreptomycin pantothenates in the cat. Antibiot Annu 554–563
Hawkins S (1958) Pharmacology of neomycin. In: Waksman SA (ed) Neomycin, its nature and practical application. Williams &Wilkins, Baltimore, pp 130–146
Hirokawa N, Haruyama A, Oike S, Naruse T (1979) Clinical evaluation of N-acetyl- glucosaminidase activity in 60 patients treated with aminoglycosides. Curr Chemother Infect Dis 1:626–627
Hoecker JL (1978) Clinical pharmacology of tobramycin in children. J Infect Dis 137:592–596
Hoeffler D, Koeppe P, Demers HG (1976) Pharmacokinetics of amikacin for treatment of urinary tract infections in patients with reduced renal function. J Infect Dis 134:S369–373
Holmes RK, Sanford JP (1974) Enzymatic assay for gentamicin and related aminoglycoside antibiotics. J Infect Dis 129:519–527
Hori K, Kawamoto K (1972) The experimental study of the side effect of lividomycin on the inner ear. Audiology Jpn 15:212–219
Hsu CH, Kurtz TW, Easterling RE, Weller JM (1974) Potentiation of gentamicin nephrotoxicity by metabolic acidosis (38212). Proceedings of the Society for Experimental Biology and Medicine 146:894–897
Hsu CH, Kurtz TW, Weller JM (1977) In vitro uptake of gentamicin by rat renal cortical tissue. Antimicrob Agents Chemother 13:192–194
Ichikawa T, Nakano I, Hirokawa I, Okada K, Abe M, Umemura K (1973) Experimental studies on absorption, excretion, distribution, and metabolism of 3’-4’-dideoxykanamy- cin B. III. Pharmacokinetic analysis in man. Jpn J Antibiot 26:262–266
Ikeda C, Tachibana A, Yano K (1979) Absorption, distribution, metabolism, and excretion of sisomicin in mice, rats, and dogs. Jpn J Antibiot 32:312–322
Inoue S (1972) Recent progress in the aminosugar antibiotics. Sci Rep Meiji Seika Kaisha 12:1–55
Israel KS, Welles JS, Black HR (1976) Aspects of the pharmacology and toxicology of tobramycin in animals and humans. J Infect Dis [Suppl] 134:97–103
Ito Y (1962 a) Chemistry of basic oligosaccharide antibiotics (1). Pharm Month 34:1–35
Ito Y (1962 b) Chemistra of basic oligosaccharide antibiotics (2). Pharm Month 34:74–99
Ito Y (1963) Recent advances in the chemistry of basic oligosaccharide antibiotics. Pharm Month 34:293–315
Jackson GG, Finland M (1969) International symposium on gentamicin, a new aminoglycoside antibiotic. J Infect Dis 119:4–5
Jaffe G, Meyers BR, Hirschman SZ (1974) Pharmacokinetics of tobramycin in patients with stable renal impairment, patients, undergoing peritoneal dialysis, and patients on chronic hemodialysis. Antimicrob Agents Chemother 5:611–616
Jerauld R, Silverblatt FJ (1978) Effect of N-methylnicotinamide on the renal accumulation and reabsorption of gentamicin in rats. Antimicrob Agents Chemother 13:893–894
Kajimoto Y, Kuramoto M (1967) Toxicity of gentamicin. Chemotherapy (Tokyo) 15:490–496
Kaneko Y, Nakagawa T, Tanaka K (1970) Reissner’s membrane after kanamycin administration. Arch Otolaryngol 92:457–462
Kanzaki J (1966) The Preyer’s reflex of the guinea pig as the hearing index. Audiology Jpn 60:940–948
Keller H, Krupe W, Sous H, Muckter H (1955) The reduction of the toxicity of basic strep- tomyces antibiotics. I. Streptomycin and dihydrostreptomycin. Arzneim Forsch 5:170–176
Kellerhals B (1979) Perilymph production and cochlear blood flow. Acta Otolaryngol (Stockh) 187:370–374
Kendall MJ, Wise R, Andrews JM, Bedford KA (1978) A pharmacological study of VK-18892 and amikacin. Antimicrob Agents Chemother 4:459–463
Kirby WMM, Clarke JT, Libke RD, Regamey C (1976) Clinical pharmacology of amikacin and kanamycin. J Infect Dis 134:S312–315
Kluwe WM, Hook JB (1978) Functional nephrotoxicity of gentamicin in the rat. Toxicol Appl Pharmacol 45:163–175
Koeda T, Moriguchi M (1973) Teratological studies of 3’,4’-dideoxykanamycin B in rats and mice. Jpn J Antibiot 26:40–48
Koeda T, Odaki M, Niizato T, Watanabe H (1970 a) Toxicological studies of vistamycin. Clin Rep 4:14–37
Koeda T, Shibata U, Nakazawa T, Asaoka H, Yamagami K (1970 b) Pharmacological studies on vistamycin. Clin Rep 4:39–51
Koeda T, Odaki M, Hisamatsu T, Sasaki H, Yokota M, Niizato T, Uchida S (1973 a) Studies on subacute toxicity of 3’,4’-dideoxykanamycin B (DKB). Jpn J Antibiot 26:228–246
Koeda T, Odaki M, Hisamatsu T, Sasaki H, Yokota M, Niizato T, Uchida S (1973 b) Studies on chronic toxicity of 3’,4’-dideoxykanamycin B. Jpn J Antibiot 26:247–261
Koeda T, Shibata U, Asaoka H, Kabata Y, Yamaki Y (1973 c) Pharmacological studies on 3’,4’-dideoxykanamycin B (DKB). Jpn J Antibiot 26:28–39
Komiya I, Hayasaka Y, Murata S, Komai T, Umemura K (1973) Experimental studies on absorption, excretion, distribution, and metabolism of 3’,4’-dideoxykanamycin B. I. Absorption, excretion, distribution, and metabolism in rats. Jpn J Antibiot 26:49–54
Komiya I, Murata S, Umemura K, Tomono N, Kikai S, Fujita M (1981 a) Pharmacokinetics of dibekacin in rabbits and dogs. J Pharm Dyn, vol 4, pp 362–373
Komiya I, Murata S, Umemura K, Tomono N, Kikai S, Fujita M (1981 b) Acute toxicity and pharmacokinetics of dibekacin in mice. J Pharm Dyn, vol 4, pp 356–361
Kornguth ML, Kunin CM (1977) Distribution of gentamicin and amikacin in rabbit tissues. Antimicrob Agents Chemother 11:974–977
Kuhar MJ, Mak LL, Lietman P (1979) Autoradiographic localization of [3H] gentamicin in the proximal renal tubules of mice. Antimicrob Agents Chemother 15:131–133
Kuramoto M, Okubo T, Lee S, Ishimura Y, Morimoto J (1975) Toxicological studies of tobramycin in mice and rats. Chemotherapy (Tokyo) 23:1470–1493
Lamb JW, Mann JM, Simmons RJ (1972) Factors influencing the microbiological assay of tobramycin. Antimicrob Agents Chemother 1:323–328
Lange G (1975) Das Verhalten der Labyrinth-Funktionen des Affen (Macacus rhesus) unter Streptomycin-Belastung. Arch Otorhinolaryngol 211:35–41
Lawson DH (1972) Effects of furosemide on antibiotic-induced renal damage in rats. J Infect Dis 126:593–600
Letourneau Saseb L, Lapierre L, Daigneault R, Homme MP, St Lous G, Sirois G (1977) Gentamicin pharmacokinetics during hemodialysis in patients suffering from chronic renal failure. Int J Clin Pharmacol Biopharm 15:116–120
Levy J, Klastersky J (1975) Correlation of serum creatinine concentration and amikacin half-life. J Clin Pharmacol 15:705–707
Lewis JE, Nelson JS, Elder HA (1972) Radioimmunoassay of an antibiotic gentamicin. Nature New Biol 239:214–215
Lewis JE, Nelson JC, Elder HA (1975) Amikacin; a rapid and sensitive radioimmunoassay. Antimicrob Agents Chemother 7:42–45
Lindsen JR, Proctor LR, Work WP (1960) Histopathologic inner ear changes in deafness due to neomycin in a human. Laryngoscope 70:382–392
Lockwood WR, Bower JD (1973) Tobramycin and gentamicin concentrations in the serum of normal and anephric patients. Antimicrob Agents Chemother 3:125–129
Luft FC, Kleit SA (1974) Renal parenchymal accumulation of aminoglycoside antibiotics in rats. J Infect Dis 130:656–659
Luft FC, Walker PD, Yum MN, Kleit SA (1975) Gentamicin concentration in human kidney cortex. Clin Res 23:477A
Lund ME, Blazevic DJ, Matsen JM (1973) Rapid gentamicin bioassay using a multiple-anti- biotic-resistant strain of Klebsiella pneumoniae. Antimicrob Agents Chemother 4:569–573
Lurie MH, Rahway NJ (1956) The ototoxicity of dihydrostreptomycin and neomycin in the cat. Ann Otol Rhinol Laryngol 62:1128–1148
Lutz MD (1978) Characteristic of gentamicin accumulation by proximal straight renal tubules in vitro. Clin Res 26:140A
Madhavan T, Yaremchuk K, Levin N, Pohlod D, Burch K, Fisher E, Cox F, Quinn EL (1976) Effect of renal failure and dialysis on the serum concentration of the aminoglycoside, mikacin. Antimicrob Agents Chemother 10:464–466
Maitra SK, Yoshikawa TT, Steyn CM, Guze LB, Schotz MC (1978) Amikacin assay in serum by high-performance liquid chromatography. Antimicrob Agents Chemother 14:880–885
Malacoff RE, Finkelstein FO, Andriole VT (1975) Effect of peritoneal dialysis on serum levels of tobramycin and clindamycin. Antimicrob Agents Chemother 8:574–580
Matsuzaki M, Nakamura K, Akutsu S, Sekino M, Hirata A, Asano M, Kishimoto K, Fukushima M (1975 a) Studies on the toxicity of amikacin (BB-K8), I. Acute toxicity and subacute toxicity in rats. Jpn J Antibiot 28:415–433
Matsuzaki M, Nakamura Y, Yoshida A, Sekine M, Iisue K, Asano M, Onodera K, Watanabe K (1975 b) Studies on the toxicity of amikacin (BB-K8). II. Chronic toxicity in rats. Jpn J Antibiot 28:434–457
Matsuzaki M, Akutsu S, Yoshida A, Onodera A, Sekine M, Tsuchida M, Asano M (1975 c) Studies on the toxicity of amikacin (BB-K8). III. Subacute toxicity of amikacin (BB-K8) in dogs. Jpn J Antibiot 28:458–484
Matsuzaki M, Yoshida A, Akutsu S, Nakamura K, Sekino M, Okuyama D, Asano M (1975 d) Studies on the toxicity of amikacin (BB-K8). IV. Chronic toxocity in dogs. Jpn J Antibiot 28:485–523
Matsuzaki M, Onodera K, Okazaki I, Nakajima A, Akima T, Koshino M, Kishimoto K (1975 e) Pharmacological studies of amikacin (BB-K8). Jpn J Antibiot 28:385–400
Mays DL, VanApeldoorn RJ, Lauback RG (1976) High-performance liquid chromatographic determination of kanamycin. J Chromatogr 120:93–102
McHenry MC, Wagner JG, Hall PM, Vidt DG, Gavan TL (1976 a) Amikacin in renal failure. Clin Pharmacol Ther 19:112a
McHenry MC, Wagner JG, Hall PM, Vidt DG, Gavan TL (1976 b) Pharmacokinetics of amikacin in patients with impaired renal function. J Infect Dis 134:S343–354
Meyers BR, Hirschman SZ, Warmser G, Siegel D (1977) Pharmacokinetic study of netilmicin. Antimicrob Agents Chemother 12:122–123
Mirhij NJ, Roberts RJ, Myers MG (1978) Effect of hypoxemia upon aminoglycosides serum pharmacokinetics in animals. Antimicrob Agents Chemother 14:344–347
Mitchell CJ, Bullock S, Ross BD (1977) Renal handling of gentamicin and other antibiotics by the isolated rat kidney. Antimicrob Agents Chemother 3:593–600
Molgó J, Lameignan M, Uchiyama T, Lechat P (1979) Inhibitory effect of kanamycin on evoked transmitter release. Reversal by 3’,4’-diaminopyridine. Eur J Pharmacol 57:93–97
Momose S (1969) A new approach to the pathogenesis of acute tubular necrosis: with special reference to tubular damages occurred from coincidental administration of aminoglycoside antibiotics and sodium alginate. Jpn J Urol 60:823–833
Mondorf AW, Breider J, Hendus J, Scherberich JE, Mackenrodt G, Shah PM, Stille W, Schoeppe W (1978) Effect of aminoglycosides on proximal tubular membranes of the human kidney. Eur J Clin Pharmacol 13:133–142
Mootz W, Schondorf J, Werner G (1972) Elektronenmikroskopische Untersuchungen am Plexus cochlearis nach Kanamycinintoxikation. Acta Otolaryngol (Stockh) 73:38–43
Mori H, Koga T, Kawahara T, Tamura H, Nakamura T (1972 a) The safety test of livid- omycin (1). Acute, subacute and chronic toxicity test of lividomycin. Pharmacometrics 6:787–812
Mori H, Kakishita T, Katoh Y (1972 b) The safety test of lividomycin (2). Effect of lividomycin on development of fetuses and newborns’ mouse. Pharmacomedia 6:813–820
Mori H, Saitoh N, Katoh Y (1973) The safety test of liviodomycin (5). Effect of lividomycin on development of fetuses and newborn of rabbits. Pharmacomedia 7:1241–1250
Moriyama S (1959) Studies on streptomycin deafness in its early stage. Jpn Otolaryngol 62:107–118
Murata S, Kadosawa H, Shomura T, Umemura K (1971) Distribution, metabolism and excretion of ribostamycin. Yakuzaigaku 3:1–7
Nakai Y, Yamamoto K, Iwamoto T (1972) Electromicroscopic study of kanendomycin and vistamycin ototoxicity. Audiology Jpn 15:202–210
Nakai Y, Yamamoto K, Zushi K, Fujimoto A (1974) The influence of amikacin (BB-K8) upon the cochlea. An electron microscopical study. Jpn J Antibiot 27:212–217
Nakai Y, Fujimoto A, Yamamoto K (1975) Combined effect of aminoglycoside antibiotics and potent diuretics on the cochlea. Audiology Jpn 18:290–298
Nakazawa S, Satoh H, Watanabe O, Sadaoka K, Fujii N, Abe M, Umemura K (1973) Experimental studies on absorption, excretion, distribution, and metabolism of 3’,4’- dideoxykanamycin B. IV. Pharmacokinetic analysis in pediatric field. Jpn J Antibiot 26:454–458
Nieminen L, Kasaun A, Kangas L, Sairio E, Anttila M (1978) Renal accumulation of amikacin, tobramycin, and gentamicin in the rat. Experientia 34:1335–1336
Niizato T, Koeda T, Tsuruoka T, Inoue S, Niida T (1976) Protective effects of D-glucaro- δ-lactam against aminoglycoside-induced nephrotoxicity in rats. J Antibiot (Tokyo) 29:833–840
Noone P, Pasaons TMC, Pattison JR, Slack RCB, Garfield-Davis D, Hughes K (1974) Experience in monitoring gentamicin therapy during treatment of serious gram-negative sepsis. Br Med J 1:477–481
Nurazyan AG (1976) Absorption, distribution, and retention of neomycin in gravid rabbits and fetus. Antibiotiki 21:625–630
Ogawa A (1975) The effects of ototoxic antibiotics on the sensory epithelia of the inner ear; a functional and histochemical study. Audiology Jpn 18:1–19
Ohtani I, Ohtsuki K, Omata T, Ouchi J, Saito T (1977) Potentiation of cochlear and renal damage resulting from furosemide and aminoglycoside antibiotics. Chemotherapy (Tokyo) 25:2348–2360
Ohtani I, Ohtsuki K, Omata T, Ouchi J (1978 a) Interaction of bumetanide and kanamycin. Audiology Jpn 81:554–561
Ohtani I, Ohtsuki K, Omata T, Ouchi J, Saito T (1978 b) Potentiation and its mechanism of cochlear damage resulting from furosemide and aminoglycoside antibiotics. ORL 40:53–63
Ohtani I, Ohtsuki K, Aikawa T, Ouchi J, Nakayoshi T (1979) A comparative study on the ototoxicity of dibekacin and tobramycin administered by intravenous infusion. Jpn J Antibiot 32:990–997
Ohyama S, Yoshimura M (1975) The role and behavior of the endocochlear potential in the inner ear. Audiology Jpn 18:255–260
Oksenhendler G, Leroy A, Humbert G, Fillastre JP, Winkler C (1977) Pharmacocinetique des nouveaux antibiotiques du groupe des aminosides: tobramycine, lividomycine, ami- kacine, sisomycine chez le sujet a function renale normale et chez l’insuffisant renal regies de posologie. Anesth Analg (Paris) 34:93–110
Oshita K (1959) Pharmacological studies on kanamycin. Med J Hiroshima Univ 7:1029- 1062
Otori H (1967) Influence of gentamicin on the fetuses of Wistar rats and KR-JCK mice. Chemotherapy (Tokyo) 15:497–500
Paradelis AG, Triantaphyllidis C, Fidani V, Logaras G (1974) The action of the aminogly- cosidic antibiotic gentamicin on isolated rat diaphragm. Arzneim Forsch (Drug Res) 24:1774–1779
Paradelis AG, Triantaphyllidis C, Markomichelakis JM, Logaras G (1977) The neuromuscular blocking activity of aminodeoxykanamycin as compared with that of other aminoglycoside antibiotics. Arzneim Forsch 27:141–143
Parker FL, James WL (1978) The effect of various topical antibiotic and antibacterial agents on the middle and inner ear of the guinea pig. J Pharm Pharmacol 30:236–239
Pechére JC, Dugal R (1976) Pharmacokinetics of intravenously administered tobramycin in normal volunteers and renal impaired and hemodialyzed patients. J Infect Dis 134:S118–124
Pechére JC, Roy B, Dugal R (1976 a) Distribution and elimination kinetics of intravenously and intramuscularly administered tobramycin in man. Int J Clin Pharmacol Biopharm 14:313–318
Pechére JC, Pechere M-M, Dugal R (1976 b) Clinical pharmacokinetics of sisomicin: dosage schedules in renal impaired patients. Antimicrob Agents Chemother 9:761–765
Pechére JC, Dugal R, Pechere MM (1978 a) Kinetics of netilmicin in man. Clin Pharmacol Ther 23:677–684
Pechére JC, Dugal R, Pechere MM (1978 b) Pharmacokinetics of netilmicin in renal insufficiency and hemodialysis. Clin Pharmacokinet 3:395–506
Penang GW, Jackson GG, Chion WK (1977) High-pressure liquid chromatographic assay of netilmicin in plasma. Antimicrob Agents Chemother 12:707–709
Pijck J, Hallynck T, Soep H, Baert L, Daneels R, Baelaert J (1976) Pharmacokinetics of amikacin in patients with renal insufficiency: relation of half-life and creatinine clearance. J Infect Dis 134:5331–5341
Raab WP, Windisch J (1973) Antagonism of neomycin by heparin. Arzneim Forsch 23:1326–1328
Ramirez-Ronda CH, Holms RK, Sanford JP (1975) Effect of divalent cations on binding of aminoglycoside antibiotics to human serum proteins and to bacteria. Antimicrob Agents Chemother 7:239–245
Rauws AG, VanKlingeren B (1978) Estimation of antibiotic levels in interstitial fluid from whole tissue levels. Scand J Infect Dis [Suppl] 14:186–188
Regamey C, Schaberg D, Kirby WMM (1972) Inhibitory effect of heparin on gentamicin concentrations in blood. Antimicrob Agents Chemother 1:329–332
Regeur L, Golding H, Jensen H, Kampman JP (1977) Pharmacokinetics of amikacin during hemodialysis and peritoneal dialysis. Antimicrob Agents Chemother 11:214–218
Reiffensten JC, Holmes SW, Hottendorf GH, Bierwagen MF (1973) Ototoxicity studies with BB-K8, a new semisynthetic aminoglycoside antibiotic. J Antibiot (Tokyo) 26:94–100
Revert C, Fillastre JP, Godin M, Leroy A (1978) Pharmacocinetique de la gentamicine; administration intramusculare de trois doses differentes chez des sujets ayant une fonction renale normale. Therapie 33:713–722
Ritschel WA, Banarer M, Lau Chang EF (1977) Computer-calculated kanamycin dosage regimen and monitoring. Int J Clin Pharmacol Biopharm 15:121–125
Robinson GC, Cambon KG (1964) Hearing loss in infants of tuberculous methods treated with streptomycin during pregnancy. N Engl J Med 271(18):949–951
Roth S, Naber K, Scheer M, Gruenwaldt G, Lange H (1976) Pharmacokinetics of sisomicin in patients with normal and impaired renal functions. Eur J Clin Pharmacol 10:357–365
Rudhardt M, Blauchard P, Fabre J (1978) Accumulation et persistance de aminosides dans le parenchyme renal. Nouv Presse Med 7:3819–3823
Sairio E, Kasanen A, Kangas L, Nieminen AL, Nieminen L (1978) The nephrotoxicity of renal accumulation of amikacin, tobramycin and gentamicin in rats, rabbits and guinea pigs. Exp Pathol (Jena) 15:370–375
Saito A, Katoh Y, Ishikawa K, Uemura H, Tomizawa M, Nakayama I, Satoh K (1978) Studies on sisomicin. Chemotherapy (Tokyo) 26:99–106
Sato K, Hama K (1979) Scanning electron microscopic observations of the under-surface of the tectorial membrane. J Electron Microsc (Tokyo) 28:36–42
Sato K, Koeda T, Yokota M (1979) Histopathological study on the vestibular toxicity of dibekacin and other aminoglycoside antibiotics. J Kanazawa Med Univ 4:172–175
Sawchuk RJ, Zaske DE (1976) Pharmacokinetics of dosing regimes which utilize multiple intravenous infusions; gentamicin in burn patients. J Pharmacokinet Biopharm 4:183–195
Schentag J J (1977) Gentamicin disposition and tissue accumulation on multiple dosing. J Pharmacokinet Biopharm 5:559–577
Schentag J J, Abrutyn E, Jusca WJ (1976) Pharmacokinetic characterization of gentamicin accumulation in man. Clin Pharmacol Ther 19:114
Schentag JJ, Cumbo TJ, Jusco WJ, Plaut ME (1978 a) Gentamicin tissue accumulation and nephrotoxic reactions. J Am Med Assoc 240:1067–2069
Schentag JJ, Lasezkay G, Cumbo TJ, Plaut ME, Jusco WJ (1978 b) Accumulation pharmacokinetics of tobramycin. Antimicrob Agents Chemother 13:649–656
Schentag JJ, Lasezkay G, Plaut ME, Jusco WJ, Cumbo TJ (1978 c) Comparative tissue accumulation of gentamicin and tobramycin in patients. J Antimicrob Chemother 4:23–30
Schrogie J J, Costello R, Hensley MM (1977) Pharmacokinetics of netilmicin in healthy volunteers.Clin Pharmacol Ther 21:116–117
Shiraiwa M (1966) Studies on permanent electrodes implanted on the round window of rabbits. Audiology Jpn 69:631–660
Simon HJ, Yin EJ (1970) Microbioassay of antimicrobial agents. Appl Microbiol 19:573–579
Simon VK, Mösinger EU, Malerczy V (1973) Pharmacokinetic studies of tobramycin and gentamicin. Antimicrob Agents Chemother 3:445–450
Singh YN, Marshall IG, Harrey AL (1978) Some effects of the aminoglycoside antibiotic amikacin on neuromuscular and autonomic transmission. Br J Anaesth 50:109–117
Smith CR, Lipsky J J, Lietman PS (1979) Relationship between aminoglycoside-induced nephrotoxicity and auditory toxicity. Antimicrob Agents Chemother 15:780–782
Spoendlin H, Galogh K (1964) Licht- und elektronenmikroskopische Darstellung von De-hydrogenasen in der Schuche nach Intravitalinkubation. OPL 26:159
Stanley VF, Giesecke AH, Jenkins MT (1969) Neomycin — curare, neuromuscular block and reversal in cats. Anesthesiology 31:228–232
Stevens P, Young LS (1977) Simple method for elimination of aminoglycosides from serum to permit bioassay of other antimicrobial agents. Antimicrob Agents Chemother 12:286–287
Szwed J J, Luft FC, Black HR, Elliot RA, Stuart A (1974) Comparison of the distribution of tobramycin and gentamicin in body fluids of dogs. Antimicrob Agents Chemother 5:444–446
Takabatake H, Oda T, Shiina M, Satoh Y, Ohno T (1978 a) Studies on diffusion of chemo- therapeutic agent into blood, uterine, oviduct, and ovary of rabbits and urinary recovery, of dibekacin and ampicillin. Jpn J Antibiot 31:303–306
Takabatake H, Oda T, Shiina M, Satoh Y, Ohno T (1978 b) Studies on diffusion of chemo- therapeutic agents in uterine muscle, fetus, placenta, amnion, and amniotic fluid of pregnant rabbits, of dibekacin and ampicillin. Jpn J Antibiot 31:307–309
Takeda H, Nakanishi H, Matumura S, Matsuda S, Kawakami M, Otani K, Uno O, Kaneshiro A (1975) Pharmacological studies on tobramycin, effects of tobramycin on cardiovascular, respiratory, muscular, and urinary excretory systems. Chemotherapy (Tokyo) 23:1440–1459
Takimoto M, Fujita K, Maruyama S, Yoshida H (1976) Safety test of lividomycin. III. Experimental study of the cochlear damage induced by lividomycin. Pharmacometrics 6:845–855
Tamura H, Fukakusa Y, Ogawa Y, Ouchi J (1972) The pharmacokinetics of tobramycin following intramuscular administration in new born infants. Chemotherapy (Tokyo) 24:1268–1271
Tan JS, Salstrom SJ (1977) Levels of carbenicillin, ticarcillin, cephalothin, cefazolin, cefa- mandole, gentamicin, tobramycin, and amikacin in human serum and interstitial fluid. Antimicrob Agents Chemother 11:698–700
Tanaka Y, Asanuma A, Yanagisawa K, Katsuki Y (1975) Microphonic and D.C. potentials in the organ of corti and tectrial membrane. Audiology Jpn 18:241–245
Tasaki I, Davis H, Eldredge DH (1954) Exploration of cochlear potentials in guinea pigs with microelectrode. J Acoust Soc Am 26:765–773
Thuillier C, Fillastre JP, Godin M (1977) Pharmacokinetic data on single dose of 280 mg gentamicin i. m. J Antimicrob Chemother 3:527–528
Toyoda Y, Tachibana M (1978) Tissue levels of kanamycin in correlation with oto- and nephrotoxicity. Acta Otolaryngol (Stockh) 86:9–14
Tronovec T (1978) Pharmacokinetics of gentamicin administered intratrancheally to rats. Antimicrob Agents Chemother 14:165–167
Tulkens P, Trouet A (1978) The uptake and intracellular accumulation of aminoglycoside antibiotics in lysosomes of cultures rat fibroblasts. Biochem Pharmacol 27:415–424
Ueda Y (1969) Nephrotoxicity of antibiotics. Chemotherapy (Tokyo) 17
Ueda Y, Nakamura N (1968) Nephrotoxicity of antibiotics. Farumashia 4:179–183
Ueda Y, Saitoh A, Uchiura G (1975) Nephrotoxicity of antibiotics. Gekkan Yakuji 17:35–39
Umemura K, Komiya I, Nakadori S, Sien-Yao Chow (1977) Pharmacokinetics of dibekacin after intramuscular administration in man. Jpn J Antibiot 30:650–656
Umezawa H (1964) Aminoglycoside antibiotics. In: Umezawa H (ed) Recent advances in chemistry and biochemistry of antibiotics. Nissin Tosho Insatsu, Tokyo, pp 67–84
Umezawa I, Ogawa H, Kawakubo Y, Morino T, Nishiyama Y (1976 a) Studies on acute and subacute toxicity of spectinomycin dihydrocloride pentahydrate. J Antibiot (Tokyo) 29:43–54
Umezawa I, Ogawa H, Komiyama K, Kawakubo Y, Morino T, Nishiyama Y (1976 b) Studies on chronic toxicity of spectinomycin dihydrochloride pentahydrate. Jpn J Antibiot 29:55–60
Vogelstein B, Kowarski AA, Lietman PS (1977 a) Continuous sampling as a pharmacokinetic tool. Clin Pharmacol Ther 22:131–139
Vogelstein B, Kowarski A A, Lietman PS (1977 b) The pharmacokinetics of amikacin in children. J Pediat 91:333–339
Wagman GH, Oden EM, Weinstein MJ, Irwin S (1967) Effect of calcium on the toxicity of gentamicin. Antimicrob Agents Chemother 1966:175–181
Waitz J A, Moss EL Jr, Weinstein MJ (1971) Aspects of the chronic toxicity of gentamicin sulfate in cats. J Infect Dis 124:125–129
Waksman SA (1949) Clinical use of streptomycin. Streptomycin, nature and practical application. Williams &Wilkins, Baltimore, pp 279–560
Walker JM, Wise R, Mitchard M (1979) The pharmacokinetics of amikacin and gentamicin in volunteers: a comparison of individual differences. J Antimicrob Chemother 5:95–99
Watanabe Y, Nakajima R, Oda R, Uno M, Naitoh T (1971) Experimental study on the transfer of kanamycin to the inner ear fluids. Med J Osaka Univ 21:257–263
Watanuki K, Gottesberg AM (1971) Toxic effects of streptomycin and kanamycin upon the sensory epithelium of thecrista ampullaris. Acta Otolaryngol (Stockh) 72:59–67
Watson EH, Stow RM (1948) Streptomycin therapy, effects on fetus. J Am Med Assoc 137:1599–1600
Wefer G, Bray C (1930) The nature of acoustic response. J Exp Physiol 13:373
Weinstein L (1970) Chemotherapy of microbial disease. In: Goodman LS; Gilman A (eds) The pharmacological basis of therapeutics. Macmillan, New York Toronto London, pp 1090–1247
Weitnauer G, Mattei A, Sinoncini F (1957) Acute and chronic toxicity of some complex salts of streptomycin and dihydrostreptomycin. Farmaco [Sci] 12:899–927
Whelton A, Carter GG, Walker WG (1975) Gentamicin concentrations in healthy and diseased kidneys. Clin Rev 23:225A
Whelton A, Carter GG, Bryant HH, Fox L, Walker WG (1976) Therapeutic implications of gentamicin accumulation in severely diseased kidneys. Arch Intern Med 136:172–176
West BA, Brummett RE (1973) Interaction of kanamycin and ethacrynic acid. Arch Otolaryngol 98:32–37
Yamada H, Yoshida T, Hirano K, Kimura Y, Ichihashi T, Doi M, Konaka J, Katagiri K (1975) Absorption, excretion, distribution and metabolism of tobramycin. Chemotherapy (Tokyo) 23:894–899
Yamamoto K, Yoshimura K, Hirono S, Inoue Y, Sakamori M, Matsumura S, Morishige E (1975) The effects of tobramycin on the central nervous system. Chemotherapy (Tokyo) 23:1460–1469
Yamasaku F (1974) Nephrotoxicity. Chemotherapy (Tokyo) 22:210–213
Yamasaku F, Kabasawa T (1976) Serum levels of dibekacin in normal subjects and uremic patients following intramuscular injections. Chemotherapy (Tokyo) 24:1515–1520
Yamasaku F, Suzuki Y, Umemura K (1980) Pharmacokinetics of ribostamycin in healthy volunteers and patients with impaired renal function. Jpn J Antibiot 33:1318–1331
Yamashita T (1972) Histochemical studies on the effects of oxygen deprivation in the hair cells of the cortis organ. Otol Fukuoka 65:591–613
Yokota M (1977) Ototoxic effects of some aminoglycoside antibiotics on the inner ear in guinea pigs. J Showa Medical 37:535–544
Yokota M, Odaki M, Koeda T, Sato K, Akiyoshi M (1976) The safety evaluation of fradi-omycin-gramicidin-S troches “Meiji”. Jpn J Antibiot 29:841–849
Yokota M, Odaki M, Koeda T, Sato K (1977) Ototoxic effects of some aminoglycoside antibiotics on the inner ear in the spontaneously hypertensive rats (SHR). Jpn J Antibiot 30:738–743
Yoshida M, Kimura Y, Doi M, Katagiri K (1975) Micromethod for microbiological assay of to bramycin concentrations in body fluids. Chemotherapy (Tokyo) 23:886–893
Yoshioka H, Takimoto M, Nakatsugawa T, Maeda T, Tasaka Y (1974) Pharmacokineticsand clinical evaluation of BB-K8 in children. Jpn J Antibiot 27:382–388
Ziv G, Sulman FG (1972) Binding of antibiotics to bovine and ovine serum. Antimicrob Agents Chemother 2:206–213
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Koeda, T., Umemura, K., Yokota, M. (1982). Toxicology and Pharmacology of Aminoglycoside Antibiotics. In: Umezawa, H., Hooper, I.R. (eds) Aminoglycoside Antibiotics. Handbook of Experimental Pharmacology, vol 62. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68579-8_7
Download citation
DOI: https://doi.org/10.1007/978-3-642-68579-8_7
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-68581-1
Online ISBN: 978-3-642-68579-8
eBook Packages: Springer Book Archive