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Mechanism of Action of Aminoglycoside Antibiotics

  • Chapter
Aminoglycoside Antibiotics

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 62))

Abstract

Aminoglycoside antibiotics are, in general, bactericidal, showing a broad antimicrobial spectrum, and are active against mycobacteria, staphylococci, and gramnegative bacteria. Spectinomycin and kasugamycin are bateriostatic. Since the early finding that streptomycin affects protein synthesis in susceptible cells (Fitzgerald et al. 1948), extensive studies have been carried out on the effects of aminoglycosides on sensitive bacteria. Eukaryotic cells are resistant to most aminoglycosides.

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  1. N. Tanaka
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  1. Institute of Microbial Chemistry, 14-23 Kamiosaki 3-Chome, Shinagawa-ku, Tokyo, Japan

    Hamao Umezawa

  2. Research Associate, Duke University Marine Laboratory, Pivers Island, 28516, Beaufort, NY, USA

    Irving R. Hooper

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Tanaka, N. (1982). Mechanism of Action of Aminoglycoside Antibiotics. In: Umezawa, H., Hooper, I.R. (eds) Aminoglycoside Antibiotics. Handbook of Experimental Pharmacology, vol 62. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68579-8_5

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  • DOI: https://doi.org/10.1007/978-3-642-68579-8_5

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