Qualitative and quantitative histochemical, ultracytochemical, and biochemical fluorometric methods were used to investigate aminopeptidase A (APA, E.C. 22.214.171.124) in the kidney of the rat and mouse and compare it with aminopeptidase M (APM, E.C. 126.96.36.199), which was subjected to qualitative histochemical and biochemical fluorometric study. Methodological studies were done to characterize the enzymes in terms of angiotensin degradation, and animal studies to explore the possible functional significance and regulation of these enzymes in the kidney.
KeywordsProximal Tubule Brush Border Epithelioid Cell Cell Nest Renin Secretion
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