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Abstract

Our study focuses on two aminopeptidases occurring in the kidney, aminopeptidase A and aminopeptidase M, which were discovered by Pfleiderer and Celliers (1963, APM) and Glenner et al. (1962, APA). We know from biochemical studies that aminopeptidase A (APA; membrane aminopeptidase II, aspartate aminopeptidase, glutamate aminopeptidase, E.C. 3.4.11.7) is a membrane-bound enzyme (McDonald and Schwabe 1979, Kenny 1979 lit.) with a molecular weight of about 190000 (Nagatsu et al. 1970). We do not yet know the subunits of which the enzyme may be composed. It is reported that APA specifically removes N-terminal α-L-glutamic acid residues and α-L-aspartic acid residues from peptides (McDonald and Schwabe 1979). Aminopeptidase M (APM; membrane aminopeptidase I, E.C.

Keywords

Proximal Tubule Brush Border Epithelioid Cell Afferent Arteriole Efferent Arteriole 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1982

Authors and Affiliations

  • Peter Kugler
    • 1
  1. 1.Institute of AnatomyUniversity of WürzburgWürzburgFederal Republic of Germany

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