Protocols for Routine Toxicity Studies: A Statistician’s View

  • D. O. Chanter
Conference paper
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 5)


The possibility that ad libitum feeding does not allow an accurate evaluation of the effects of xenobiotics is raised. Two methods of improving the precision of routine toxicological protocols, blocking and the use of inbred or Fl hybrid strains, are discussed. The role of the statistician in the design of protocols is described.

Key words

Routine protocols Ad libitum feeding Blocking Inbred strains Fl hybrids 


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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • D. O. Chanter
    • 1
  1. 1.Huntingdon Research CentreHuntingdon, Cambs.Great Britain

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