Protocols for Routine Toxicity Studies: A Statistician’s View
The possibility that ad libitum feeding does not allow an accurate evaluation of the effects of xenobiotics is raised. Two methods of improving the precision of routine toxicological protocols, blocking and the use of inbred or Fl hybrid strains, are discussed. The role of the statistician in the design of protocols is described.
Key wordsRoutine protocols Ad libitum feeding Blocking Inbred strains Fl hybrids
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