Toxicology Reference Data for the Wistar Rat

  • P. J. Lewi
  • R. P. Marsboom
Conference paper
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 5)

Abstract

Sixty-six observations on Wistar rats, including body and organ weights, biochemistry, hematology, and urinalysis have been compiled over a period of 16 years. A statistical analysis of these observations involved 3,400 Wistar rats that served as controls in toxicity studies. The results have been recorded on synoptic charts, which provide frequency distributions, cumulative distributions and variations according to the time of observation, the sex and the age of the rats. The construction of the statistical charts, the prominent features of the distributions and the use of reference data in toxicology are discussed.

Key words

Toxicology Record-keeping Statistics Computer 

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References

  1. Lewi PJ, Marsboom RP (1981) Toxicology reference data — Wistar rat. Elsevier/North-Holland Biomedical Press, Amsterdam Oxford New YorkGoogle Scholar
  2. Wonnacott TH, Wonnacott RJ (1977) Introductory statistics. Wiley, New York, p 199Google Scholar

Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • P. J. Lewi
    • 1
  • R. P. Marsboom
    • 1
  1. 1.Research LaboratoriesJanssen Pharmaceutica NVBeerseBelgium

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