Abstract
The effects of two antispermatogenic 3-indazole-carboxylic acids on pregnancy in the rat have been studied. AF 1312/TS (1-(4-chlorobenzyl)-1H-indazole-3-carboxylic acid) when administered from day 6 to day 15 of pregnancy produced embryolethality with an LD50 of 145 mg/kg. The more potent antispermatogenic lonidamine was 7.25 times more effective, with an LD50 of 20 mg/kg. No significant teratogenicity was exerted by AF 1312/TS, whilst lonidamine was slightly effective only at embryolethal doses. The latter was also effective after a single administration on day 9, with an embryonal LD50 of 25 mg/kg, whereas the teratogenic effect was greatest on day 10. The similarity of the embryonal LD50 after single or repeated administrations suggests an interference with a specific epigenetic crisis.
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© 1982 Springer-Verlag
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Barcellona, P.S., Campana, A., Silvestrini, B., De Martino, C. (1982). The Embryotoxicity of a New Class of Antispermatogenic Agents: the 3-Indazole-Carboxylic Acids. In: Chambers, C.M., Chambers, P.L. (eds) New Toxicology for Old. Archives of Toxicology, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68511-8_35
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DOI: https://doi.org/10.1007/978-3-642-68511-8_35
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