Abstract
The documents concerning the experimental safety evaluation of drugs are evaluated in France by an advisory board of the Ministry of Health which expresses an opinion on their accuracy, indispensable for the authorization of sale. The data reported here concern 95 documents examinated between 1978 and 1981. They are related:
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To the form of presentation of the documents: 14 main kinds of defects are pointed out (lack of justification of the protocols, inadequate experimental data, etc.).
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To the substance of the experiments: 21 main kinds of defects are emphasized (erroneous choice of the doses, poor clinical examination of the animals, etc.).
In conclusion, a real effort to obtain a large and constructive exchange of information between all the parties concerned, the manufacturers, the experts, the Ministries of Health, must be continued.
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References
Anonymous (1977a) Etude comparative des protocoles toxicologiques officiels: I. Généralités. Toxicité aiguë. Rev Sci Techn Pharm 6: 197–203
Anonymous (1977b) Etude comparative des protocoles toxicologiques officiels: II. Toxicité à terme. Rev Sci Techn Pharm 6: 251–261
Claude JR (1980) Analyse rétrospective des dossiers de toxicité aiguë et à doses réitérées établie dans le cadre des demandes d’AMM. In: Bases scientifiques et réglementaires de l’évaluation des médicaments. INSERM, Paris, pp 125–130
Directives du conseil des communautés européennes 65/65/CEE 26th January 1965, 75/318/CEE 20th May 1975 and 75/319/CEE 20th May 1975
Journal Officiel de la République Française (1976) Arrêté du 10 août 1976 fixant le protocole applicable aux essais toxicologiques et pharmacologiques des spécialités pharmaceutiques. Numéro complémentaire du 22 Septembre
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© 1982 Springer-Verlag
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Claude, JR. (1982). Critical Evaluation of the Toxicological Documents Produced for the Authorization of Drugs According to the Commission of the European Communities Directives. In: Chambers, C.M., Chambers, P.L. (eds) New Toxicology for Old. Archives of Toxicology, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68511-8_3
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DOI: https://doi.org/10.1007/978-3-642-68511-8_3
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-11406-2
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