Skip to main content
SpringerLink
Log in
Book cover

Die undifferenzierten Astrozytome des Großhirns pp 3–12Cite as

Pathologie

  • Chapter

  • 15 Accesses

Part of the book series: Schriftenreihe Neurologie / Neurology Series ((NEUROSER,volume 22))

Zusammenfassung

Als Astrozytome bezeichnet man Gliome, die sich überwiegend aus Zellelementen aufbauen, die Astrozyten und/oder ihren morphologisch faßbaren Vorläufern (Gliavorläuferzellen, glial precursors) entsprechen. Unter Verwendung von Befunden der Zell- und Organkultur (36, 40) sowie Einsatz immunhistochemischer Methoden kann der Zelltyp, von welchem sich im Einzelfall ein Astrozytom hergeleitet hat, in gewissen Fällen identifiziert werden. Die Bezeichnung dieser Gliome richtet sich indessen nach wie vor nach der bei der histologischen Untersuchung vorgefundenen Hauptpopulation von Zellen. Das lichtmikroskopische Bild der Astrozytome erlaubt in vielen Fällen, eine Unterteilung der vorliegenden neoplastischen Zellen in protoplasmatische oder fibrilläre Astrozyten vorzunehmen, wenn auch der letztgenannte Zelltyp in der Häufigkeit überwiegt. Beide Typen von Astrozyten enthalten in wechselnder Menge Gliafasern. Basierend auf dem Vorliegen dieser zwei Zellgruppen, die sich auch elektronenmikroskopisch auseinanderhalten lassen (32), wurde verschiedentlich versucht, Astrozytome in mehrere Klassen oder Untergruppen zu unterteilen. Einige der am häufigsten gebrauchten Klassifikationen sind in der Tabelle 1 zusammengestellt.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Alvord EC (1976) Why do gliomas not metastasize? Arch Neurol 33:73

    Article  PubMed  Google Scholar 

  2. Anzil AP (1970) Glioblastoma multiforme with extracranial metastases in the absence of previous craniotomy. J Neurosurg 33:88

    Article  PubMed  CAS  Google Scholar 

  3. Bailey P, Cushing H (1926) A classification of tumors of the glioma group. Lippin-cott, Philadelphia

    Google Scholar 

  4. Battista AF, Bloom W, Loffmn M et al. (1961) Autotransplantation of anaplastic astrocytoma into the subcutanous tissue of man. Neurology 11:977

    PubMed  CAS  Google Scholar 

  5. Bloom WH, Castairs KC, Crompton RM et al. (1960) Autologous glioma transplantation. Lancet 11:77

    Article  Google Scholar 

  6. Brander WL, Turner DR (1975) Extracranial metastases from a glioma in the absence of surgical intervention. J Neurol Neurosurg Psychiatry 38:1133

    Article  PubMed  CAS  Google Scholar 

  7. Burger PC, Vollmer RT (1980) Histologic factors of prognostic significance in the glioblastoma multiforme. Cancer 46:1179

    Article  PubMed  CAS  Google Scholar 

  8. Davis L, Martin J, Goldstein SL et al. (1949) A study of 211 patients with verified glioblastoma multiforme. J Neurosurg 6:33

    Article  PubMed  CAS  Google Scholar 

  9. Di Lorenzo N, Palma L, Nicole S (1977) Lymphocytic infiltration in long-survival glioblastoma: Possible host’s resistance? Acta Neurochir (Wien) 39:27

    Article  Google Scholar 

  10. Dolman CL (1974) Lymph node metastases as first manifestation of glioblastoma. J Neurosurg 41:607

    Article  PubMed  CAS  Google Scholar 

  11. Duffel D, Farber L, Chou S et al. (1963) Electron microscopic observation on astrocytomas. Am J Pathol 43:439

    Google Scholar 

  12. Eccles SA, Alexander P (1974) Macrophage content of tumors in relation to metastatic spread and host immune reacton. Nature 250:667

    Article  PubMed  CAS  Google Scholar 

  13. Elvidge AR, Penfield W, Cone W (1937) Gliomas of the central nervous system, a study of 210 verified cases. Res Publ Assoc Nerv Ment Dis 16:107

    Google Scholar 

  14. EORTC Brain Tumor Group (1978) Effect of CCNU on survival rate, objective remission and duration of free interval in patients with malignant brain glioma. Eur J Cancer 14:851

    Google Scholar 

  15. Erlich S, Davis RL (1978) Spinal subarachnoid metastasis from primary intracranial glioblastoma multiforme. Cancer 42:2854

    Article  PubMed  CAS  Google Scholar 

  16. Frankel SA, German WJ (1958) Glioblastoma multiforme. Review of 219 cases with regard to natural history, pathology, diagnostic methods and treatment. J Neurosurg 15:489

    Article  PubMed  CAS  Google Scholar 

  17. Grace JT, Perese DM, Metzgar RS et al. (1961) Tumor autograft responses in patients with glioblastoma multiforme. J Neurosurg 18:159

    Article  Google Scholar 

  18. Gullotta F, Flieder E (1972) Spongioblastomas, astrocytomas and Rosenthal fibers. Ultrastructural, tissue culture and enzyme histochemical investigations. Acta Neuropathol (Berl) 22:68

    Article  CAS  Google Scholar 

  19. Hossmann KA, Wechsler W (1965) Zur Feinstruktur menschlicher Spongioblastome. Dtsch Z Nervenheilkd 187:327

    Article  PubMed  CAS  Google Scholar 

  20. Hulbani S, Goodman PA (1976) Glioblastoma multiforme with extraneural metastasis in the absence of previous surgery. Cancer 37:1577

    Article  Google Scholar 

  21. Jelsma R, Buey PC (1967) The treatment of glioblastoma multiforme of the brain. J Neurosurg 27:388

    Article  PubMed  CAS  Google Scholar 

  22. Kernohan JW, Mabon RF, Svien HJ et al. (1949) A simplified classification of the gliomas. Proc Staff Meet Mayo Clin 24:71

    CAS  Google Scholar 

  23. Kretschmer H (1974) Die extrakranielle Metastasierung intrakranieller Geschwülste. Zentralbl Neurochir 35:81

    PubMed  CAS  Google Scholar 

  24. Kuhlendahl H, Miltz H, Wüllenweber R (1973) Die Astrozytome des Großhirns. Acta Neurochir (Wien) 29:151

    Article  Google Scholar 

  25. Kung PC, Lee JC, Bakay L (1969) Vascular invasion by glioma cells in man: an electron microscopic study. J Neurosurg 31:339

    Article  PubMed  CAS  Google Scholar 

  26. Lobsiger E, Jenzer G, Locher G (1977) Ungewöhnlich lange Überlebenszeit bei Astrozytom Grad III–IV. Nervenarzt 48:626

    PubMed  CAS  Google Scholar 

  27. Maunoury R, Vedrenne C, Constans JP (1975) Infiltration lymphocytaire dans les gliomes humains. Neurochirurgie 21:213

    PubMed  CAS  Google Scholar 

  28. Moertel CG, Dockerty MB, Baggenstoss A (1961) Multiple primary malignant neoplasms. III. Tumors of multicentric origin. Cancer 14:238

    Article  Google Scholar 

  29. Netsky MG, August B, Fowler W (1950) The longevity of patients with glioblastoma multiforme. J Neurosurg 7:261

    Article  PubMed  CAS  Google Scholar 

  30. Palma L, Di Lorenzo N, Guidetti B (1978) Lymphocytic infiltrates in primary glioblastomas and recidivous gliomas. J Neurosurg 49:854

    Article  PubMed  CAS  Google Scholar 

  31. Pasquier B, Pasquier D, N’Golet A et al. (1980) Extraneural metastasis of astrocytomas and glioblastomas. Cancer 45:112

    Article  PubMed  CAS  Google Scholar 

  32. Peters A, Palay SL, Webster HD (1970) The fine structure of the nervous system. The cells and their processes. Harper & Row, New York

    Google Scholar 

  33. Raimondi AJ, Mullan S, Evans JP (1962) Human brain tumors: An electron-microscope study. J Neurosurg 19:731

    Article  PubMed  CAS  Google Scholar 

  34. Ringertz N (1950) Grading of gliomas. Acta Pathol Microbiol Scand 27:51

    Article  PubMed  CAS  Google Scholar 

  35. Rubinstein LJ (1967) Development of extracranial metastasis from a malignant astrocytoma in the absence of previous craniotomy. J Neurosurg 26:542

    Article  PubMed  CAS  Google Scholar 

  36. Rubinstein LJ, Herman MM, Foley VL (1973) In vitro characteristics of human glioblastomas maintained in organ culture systems. Light microscopy observations. Am J Pathol 71:61

    PubMed  CAS  Google Scholar 

  37. Rüssel DS, Rubinstein LJ (1977) Pathology of tumors of the nervous system. Arnold, London

    Google Scholar 

  38. Scherer HJ (1940) Cerebral astrocytomas and their derivatives. Am J Cancer 40: 159

    Google Scholar 

  39. Seiler RW (1981) Late results of multimodality therapy of high-grade supratentorial astrocytomas. Surg Neurol 15:88

    Article  PubMed  CAS  Google Scholar 

  40. Sipe JC, Herman MM, Rubinstein LJ (1973) Electron microscopic observations on human glioblastomas and astrocytomas maintained in organ culture systems. Am J Pathol 73:589

    PubMed  CAS  Google Scholar 

  41. Smith DR, Hardman JM, Earle KM (1969) Metastasizing neuroectodermal tumors of the central nervous system. J Neurosurg 31:50

    Article  PubMed  CAS  Google Scholar 

  42. Takeuchi K, Hoshino K (1977) Statistical analysis of factors affecting survival after glioblastoma multiforme. Acta Neurochir (Wien) 37:57

    Article  CAS  Google Scholar 

  43. Taveras JA, Thompson HG, Pool JL (1962) Should we treat glioblastoma multiforme? AJR 87:473

    CAS  Google Scholar 

  44. Wakamatsu T, Matsuo T, Kawano S et al. (1971) Glioblastoma with extracranial metastasis through ventriculo-pleural shunt: Case report. J Neurosurg 34:697

    Article  PubMed  CAS  Google Scholar 

  45. Walker MD, Brain Tumor Study Group (1978) Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas. J Neurosurg 49:333

    Article  PubMed  CAS  Google Scholar 

  46. Weir B (1973) The relative significance of factors affecting postoperative survival in astrocytomas grades 3 and 4. J Neurosurg 38:448

    Article  PubMed  CAS  Google Scholar 

  47. Wikstrand CJ, Bigner DD (1980) Immunobiologic aspects of the brain and human gliomas. A review. Am J Pathol 98:515

    Google Scholar 

  48. Zülch HJ (1956) Biologie und Pathologie der Hirngeschwülste. In: Krenkel W, Olivecrona H, Tönnis W (eds) Pathologische Anatomie der raumbeengenden intra-kraniellen Prozesse. Springer, Berlin Göttingen Heidelberg (Handbuch der Neurochirurgie, Bd 3)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Neurochirurgische Universitätsklinik Inselspital, CH-3010, Bern, Schweiz

    Oberarzt PD Dr. med. Rolf W. Seiler

Authors
  1. Oberarzt PD Dr. med. Rolf W. Seiler
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1982 Springer-Verlag Berlin · Heidelberg

About this chapter

Cite this chapter

Seiler, R.W. (1982). Pathologie. In: Die undifferenzierten Astrozytome des Großhirns. Schriftenreihe Neurologie / Neurology Series, vol 22. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68505-7_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-68505-7_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-68506-4

  • Online ISBN: 978-3-642-68505-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation