Abstract
Interferons are a group of inducible cellular proteins that interact with mammalian and other vertebrate cells and render them resistant to infection by a wide variety of RNA-containing or DNA-containing viruses. In addition to a marked antiviral effect, interferons cause numerous changes in the phenotype of target cells, including a reduction in the rate of cell proliferation and alterations in the structure and function of the cell surface, the distribution of cytoskeletal elements, and the expression of several differentiated cellular functions. The use of interferons and interferon inducers to treat human viral and neoplastic diseases is currently under intensive investigation. Considerable attention is thus focused on the structure and function of human interferons. Furthermore, investigations of the mechanisms which underlie the induction and the actions of interferons have led to novel insights into the regulation of gene expression in eukaryotic cells as well as into the pathophysiology of viral diseases. Thus, interferon research represents an important and rapidly advancing area of biomedical research today.
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Sehgal, P.B., Pfeffer, L.M., Tamm, I. (1982). Interferon and Its Inducers. In: Came, P.E., Caliguiri, L.A. (eds) Chemotherapy of Viral Infections. Handbook of Experimental Pharmacology, vol 61. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68487-6_6
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