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Amantadine and Its Derivatives

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Chemotherapy of Viral Infections

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 61))

Abstract

Amantadine hydrochloride (1-adamantanamine hydrochloride) was the first antiviral chemotherapeutic agent (1966) to be licensed for general use in the United States. However, despite the demonstrated efficacy of this compound in the prophylaxis (and more recently in the treatment) of influenza A virus infections, it has never been widely employed and its recommended use remains the subject of considerable controversy (Sabin 1978).

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Authors
  1. J. L. Schulman
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Editors and Affiliations

  1. Sterling-Winthrop Research Institute, 12144, Rensselaer, NY, USA

    Paul E. Came

  2. Department of Microbiology, University of Pittsburgh, School of Medicine, 15261, Pittsburgh, PA, USA

    Lawrence A. Caliguiri

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© 1982 Springer-Verlag Berlin Heidelberg

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Schulman, J.L. (1982). Amantadine and Its Derivatives. In: Came, P.E., Caliguiri, L.A. (eds) Chemotherapy of Viral Infections. Handbook of Experimental Pharmacology, vol 61. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68487-6_4

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  • DOI: https://doi.org/10.1007/978-3-642-68487-6_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-68489-0

  • Online ISBN: 978-3-642-68487-6

  • eBook Packages: Springer Book Archive

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