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Rheological Aspects

  • H. Schmid-Schönbein
  • K. Messmer
  • L. Chaussy
  • W. J. Stelter
  • W. Stippig

Abstract

Clinical medicine has finally discovered the microcirculation, after it became clear that tissue perfusion, oxygen supply and catabolite removal does not depend only on the integrity of the main large blood vessels and the pumping heart. In an attempt to understand the consequences of degenerative vascular diseases, it has now been shown that the terminal system of exchange vessels is not merely a passive irrigation system, but affects its own perfusion and the transmural exchange of metabolites by endogenous mechanisms that have largely evaded the quantification by the methods presently used in angiology and/or cardiology.

Keywords

Myocardial Blood Flow Coronary Sinus Blood Viscosity Central Retinal Vein Occlusion Myocardial Oxygen Consumption 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Biro GP, Beresford-Kroeger BSc, Hendry P (to be published) Early rheological changes in the blood flow in acute experimental coronary occlusion in the dog and the effect of hemodilution with stroma-free hemoglobin. Am Heart JGoogle Scholar
  2. 2.
    Cohn LH, Lambert JJ, Florian A, Moses R, Vandevanter S, Kirk E, Collins JJ (1975) Effects of hemodilution on acute myocardial ischemia. J Surg Res 18: 523PubMedCrossRefGoogle Scholar
  3. 3.
    Driessen GK, Heidtmann H, Schmid-Schönbein H (1979) Effect of hematocrit on red cell velocity in the capillaries of rat mesentery during hemodilution and hemoconcentration. Pflügers Arch 380: 1–6PubMedCrossRefGoogle Scholar
  4. 4.
    Eckstein RW (1955) Development of interarterial anastomoses by chronic anemia. Circ Res 3: 306PubMedGoogle Scholar
  5. 5.
    Guyton AC, Coleman TG, Granger HJ (1972) Circulation: Overall regulation. Annu Rev Physiol 34: 13–46PubMedCrossRefGoogle Scholar
  6. 6.
    Heidtmann H, Driessen G, Haest CWM, Kamp D, Schmid-Schönbein H (1979) The influence of rheological factors on the recovery of the microcirculation following arterial hypotension. Micro vase Res 18: 449Google Scholar
  7. 7.
    Hossmann KA (to be published) Experimentelle Untersuchungen über die Rezirkulation des Gehirns nach Kreislaufstillstand. Verh. der Gesellschaft für Mikrozirkulation, Mainz, 1979. Microvase ResGoogle Scholar
  8. 8.
    Jan KM, Chien S (1977) Effect of hematocrit variations on coronary hemodynamics and oxygen utilization. Am J Physiol 233: 106–113Google Scholar
  9. 9.
    Johansson B, Linder E, Seeman T (1967) Effects of hematocrit and blood viscosity on myocardial blood flow during temporary coronary occlusion in dogs. Scand J Thorac Cardiovasc Surg 1: 165–174PubMedCrossRefGoogle Scholar
  10. 10.
    Joshikawa H, Powell WJ, Bland JH, Lowenstein E (1973) Effect of acute anemia on experimental myocardial ischemia. Am J Cardiol 32: 670CrossRefGoogle Scholar
  11. 11.
    Kiesewetter H, Schmid-Schönbein H, Radtke H, Stolwerk G (1979) In vitro demonstration of collateral blood viscidation: Flow measurements in a model of vascular networks. Microvasc Res 17: 72Google Scholar
  12. 12.
    Lundsgaard-Hansen P (1979) Hemodilution - New clothes for an anemic emperor. Vox Sang 36: 321PubMedCrossRefGoogle Scholar
  13. 13.
    Murray JF, Escobar E (1968) Circulatory effects of blood viscosity: comparison of methemoglobinemia and anemia. J Appl Physiol 25: 594–599PubMedGoogle Scholar
  14. 14.
    Rieger H, Leyhe A, Schmid-Schönbein H, Schoop W, Schneider R, Malotta H (1972) Isovo- lämische Hämodilution bei peripherer arterieller Verschlußkrankheit. Konzepte, Methoden und vorläufige Ergebnisse. In: Alexander K, Cachovan M (eds) Diabetische Angiopathien. Witzstrock, Baden-Baden, pp 354–358Google Scholar
  15. 15.
    Rieger H, Köhler M, Schoop W, Schmid-Schönbein H, Roth FJ, Leyhe A (1979) Hemodilution (HD) in patients with ischemic sein ulcers. Klin Wochenschr 57: 1153–1161PubMedCrossRefGoogle Scholar
  16. 16.
    Schmid-Schönbein H (1979) Rheologische Deutung des “Nicht-Obturationsinfarktes” (DOERR). Verh. Dt sch Ges Herz Kreislaufforsch 45: 23–38Google Scholar
  17. 17.
    Schmid-Schönbein H (to be published) Valediction to “blood viscosity” and salutation to “blood fluidity”: Factors that promote and factors that curtail the fluidity of erythrocytes and thus of erythrocyte dispersions (editorial). Basic Res CardiolGoogle Scholar
  18. 18.
    Schmid-Schönbein H, Rieger H (1980) Rationale for isovolemic hemodilution and first clinical results. In: Lowe GDO, Forbes CD (eds) Clinical aspects of blood viscosity and cell deforma-bility. Springer, Berlin Heidelberg New York, pp 211–226Google Scholar
  19. 19a.
    Von Restorff W, Höfling B, Holtz J, Bassenge E (1975) Effect of increased blood fluidity through hemodilution on coronary circulation at rest and during exercise in dogs. Pflügers Arch. 357: 15–24CrossRefGoogle Scholar
  20. 19b.
    Von Restorff W, Höfling B, Holtz J, Bassenge E (1975) Effect of increased blood fluidity through hemodilution on general circulation at rest and during exercise in dogs. Pflügers Arch. 357: 25–34CrossRefGoogle Scholar
  21. 20.
    Wiederholt M, Leonhardt H, Schmid-Schönbein H, Hager H (to be published) Die Behandlung von Zentralvenenverschlüssen und Zentralarterienverschlüssen mit isovolämischer Hämodilution. Klin Monatsbl AugenheilkdGoogle Scholar
  22. 22.
    Biro GP, Beresford-Kroeger D (1979) Myocardial blood flow and O2 supply following dextran- haemodilution and methaemoglobinaemia in the dog. Cardiovasc Res 13: 459–468PubMedCrossRefGoogle Scholar
  23. 23.
    Brazier J, Cooper N, Maloney JV, Buckberg G (1974) The adequacy of myocardial oxygen delivery in acute normovolemic anemia. Surgery 75: 508–516PubMedGoogle Scholar
  24. 24.
    Geha AS (1976) Coronary and cardiovascular dynamics and oxygen availability during acute normovolemic anaemia. Surgery 80: 47–53PubMedGoogle Scholar
  25. 25.
    Hagl S, Bornikoel K, Mayr N, Messmer K, Sebening F (1975) Cardiac performance during limited hemodilution. Bibl Haematol 41: 152–165PubMedGoogle Scholar
  26. 26.
    Holtz J, Bassenge E, von Restorff W, Mayer E (1976) Transmural differences in myocardial blood flow and in coronary dilatory capacity in hemodiluted conscious dogs. Basic Res Cardiol 71: 36–46PubMedCrossRefGoogle Scholar
  27. 27.
    Jan KM, Chien S (1977) Effect of hematocrit variations on coronary hemodynamics and oxygen utilization. Am J Physiol 233: H106-H113PubMedGoogle Scholar
  28. 28.
    Kettler D, Hellberg K, Klaess G, Kontokollias IS, Loos W, deVivie R (1976) Hämodynamik, Sauerstoffbedarf und Sauerstoffversorgung des Herzens unter isovolämischer Hämodilution. Anaesthesist 25: 131–136PubMedGoogle Scholar
  29. 29.
    Messmer K (1977) Acute preoperative hemodilution; an alternative to transfusion of donor blood. In: Lewis DH (ed) Dextran-30 years. Almqvist & Wiksell International, Stockholm, pp 93–110Google Scholar
  30. 30.
    Möller P, Brandt R, Fagrell B, Hellström K, Strandeil T (1979) The effect of isovolemic hemodilution in patients with chronic respiratory insufficiency. Abstracts Int Symp Pulmonary Circulation III, Praque 1979, p 111Google Scholar
  31. 31.
    Race D, Dedichen H, Schenk WG (1967) Regional blood flow during dextran-induced normovolemic hemodilution in the dog. J Thorac Cardiovasc Surg 53: 578–586PubMedGoogle Scholar
  32. 32.
    Restorff WV, Höfling B, Holty J, Bassenge E (1975) Effect of increased blood fluidity through hemodilution on general circulation at rest and during exercise in dogs. Pflügers Arch 357: 15CrossRefGoogle Scholar
  33. 33.
    Rieger H, Leyhe A, Schopp W (1979) Weitere Erfolge mit der isovolämischen Hämodilution bei Patienten mit arteriellen Verschlußkrankheiten. In: Ehringer H, Betz E, Bollinger A, Deutsch E (eds) Gefäßwand, Rezidivprophylaxe, Raynand-Sydrom, Witzstrock, Baden-Baden, p 123Google Scholar
  34. 34.
    Rosberg B (1979) Regional lung function and central hemodynamics following normovolemic hemodilution in the dog. Acta Anaesthesiol Scand 23: 137–142PubMedCrossRefGoogle Scholar
  35. 35.
    Stelter W, Stippig S, Chaussy L, Boon J, Messmer K (1979) Myocardial blood supply during limited normovolemic hemodilution. Biorheology 16: 127Google Scholar
  36. 36.
    Wiederholt M, Leonhardt H, Schmid-Schönbein H, Hager N (1979) Treatment of central retinal vein occlusion by isovolaemic haemodilution. Microvasc Res 17: 156Google Scholar
  37. 37.
    Yates CJP, Berent A, Andrews V, Dormandy JA (1979) Increase in leg blood-flow by normo- volaemic haemodilution in intermittent claudication. Lancet II: 166–168CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1982

Authors and Affiliations

  • H. Schmid-Schönbein
    • 1
  • K. Messmer
    • 2
  • L. Chaussy
    • 2
  • W. J. Stelter
    • 2
  • W. Stippig
    • 2
  1. 1.Abteilung Physiologie der Med. Fakultät an der Rhein.-WestfTechn. HochschuleAachenGermany
  2. 2.Institut für chirurgische Forschung, Klinikum GroßhadernMünchen 70Germany

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