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Interaktionen von Ulcustherapeutica

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Book cover Ulcus-Therapie

Part of the book series: Interdisziplinäre Gastroenterologie ((GASTROENTEROLOG))

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Zusammenfassung

Von der Vielzahl der Faktoren, die die Bioverfügbarkeit und Wirkung von Medikamenten beeinflussen, gehören Arzneimittelinteraktionen zu den wichtigsten (Tabelle 1). Ihre Häufigkeit und Bedeutung wird von vielen Ärzten unterschätzt, obwohl man aus klinischen Studien weiß, daß sie in einem hohen Prozentsatz der Fälle zu unerwünschten Nebenwirkungen führen können [14, 27].

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Literatur

  1. Albert, A., Rees, C.W.: Avidity of the tetracyclines for the cations of metals. Nature 177, 433–434 (1956)

    Article  PubMed  CAS  Google Scholar 

  2. Alexander, S.F., Farage, D.J., Hassan, W.E. (Eds.): Hazards of medication. A manual on drug interactions, incompatibilities, contraindications, and adverse effects 2nd edn. Philadelphia, Toronto: Lippincott 1978

    Google Scholar 

  3. Ambre, J.J., Fischer, L.J.: Effect of coadministration of aluminium and magnesium hydroxides on absorption of anticoagulants in man. Clin. Pharmacol. Ther. 14, 231–237

    Google Scholar 

  4. Ammann, R.: Schmerzen im Bereich des Abdomens. In: Differentialdiagnose innerer Krankheiten. Hegglin, M., Siegenthaler, W. (Hrsg.), 14. Aufl.

    Google Scholar 

  5. Ayres, J.W., Weidler, D.J., MacKichan, J., Sakmar, E., Hallmark, M.R., Lemanowicz, E.F., Wagner, J.G.: Pharmacokinetics of tolmetin with an without concomitant administration of antacid in man. Eur. J. clin. Pharmacol. 12, 421–428 (1977)

    Article  PubMed  CAS  Google Scholar 

  6. Baron, J.H., Gribble, R.J.N., Rhodes, C., Wright, P.A.: Factors affecting the absorption of carbenoxolone in patients with peptic ulcer. In: Fourth Symposium on Carbenoxolone. Aver J., Parke (eds.), pp. 115–124 Londen: Butterworths, 1975

    Google Scholar 

  7. Barr, W.H., Adir, J., Garrettson, L.: Decrease of tetracycline absorption in man by sodium bicarbonate. Clin. Pharmacol. Ther. 12, 779–784 (1971)

    PubMed  CAS  Google Scholar 

  8. Becker, G., Overhoff, H.: Aluminium in der Medizin. Anwendung, Toxizität, Gefahren. Med. Welt 31, 1228–1232 (1980)

    PubMed  CAS  Google Scholar 

  9. Bennet, W.M., Singer, I., Golper, T., Feig, P., Coggins, C.J.: Guidelines for drug treatment in renal failure. Ann. Intern. Med. 86, 754–783 (1977)

    Google Scholar 

  10. Binder, HJ., Grossman, M.I., McCarthy, D.M.: Cimetidine. A status report. Curr. Prescrib. 11, 23–39 (1979)

    Google Scholar 

  11. Bint, A.J., Burtt, I.: Adverse antibiotic drug interactions. Drugs 20, 57–68 (1980)

    Article  PubMed  CAS  Google Scholar 

  12. Blaug, S.M., Gross, M.R.: In vitro adsorption of some anticholinergic drugs by various antacids. J. Pharmac. Sci. 54, 290–294 (1965)

    Google Scholar 

  13. Bodemar, G., Norlander, B., Walan, A.: Diminished absorption of Cimetidine caused by antacids. Lancet 1979 I, 445

    Google Scholar 

  14. Boston Collaborative Drug Surveillance Programm: Adverse drug interactions. JAMA 220, 1238–1239 (1972)

    Article  Google Scholar 

  15. Breckenridge, A.M., Challiner, M., Mossmann, S. et. al.: Cimetidine increases the action of warfarin in man. Proceedings of the B.P.S. pp. 392–393 (1979)

    Google Scholar 

  16. Brogden, R.N., Pinder, R.M., Sawyer, P.R., Speight, T.M., Avery, G.S.: Tri-potassium di-citrato bismuthate: A report of its pharmacological properties and therapeutic efficacy in peptic ulcer. Drugs 12, 401–411 (1976)

    Article  PubMed  CAS  Google Scholar 

  17. Brown, D.D., Juhl, R.P.: Decreased bioavailability of digoxin due to antacids and kaolin-pectin. N. Engl. J. Med. 295, 1034–1037

    Google Scholar 

  18. Burland, W.L., Darkin, D.W., Mills, M.W.: Effect of antacids on absorption of Cimetidine. Lancet 1976 II, 965

    Google Scholar 

  19. Charbon, G.A., Brouwers, A.A., Sala, A.: Histamine H1 und H2-receptors in the gastrointestinal circulation. Naunyn Schmiedebergs Arch. Pharmacol. 312, 123–129 (1980)

    CAS  Google Scholar 

  20. Chun, A.H.C., Carrigan, P.J., Hoffmann, D.J., Kershner, R.P., Stuart, J.D.: Effect of antacids on absorption of clorazepate. Clin. Pharmacol. Ther. 22, 329–335 (1977)

    PubMed  CAS  Google Scholar 

  21. Ciain, J.E., Malagelada, J.-R., Chadwick, V.S., Hofmann, A.F.: Binding properties in vitro of antacids for conjugated bile acids. Gastroenterology 73, 556–559 (1977)

    Google Scholar 

  22. Ciain, J.E., Wright, J.P., Price, R.N., Marks, I.N.: In vitro neutralizing capacity of commercially available antacid mixtures, and their role in the treatment of peptic ulcer. S.A. Med. 57, 158–160 (1980)

    Google Scholar 

  23. Cole, J.J., Charles, B.G., Ravenscroft, P.J.: Interaction of Cimetidine with tetracycline absorption. Lancet 1980 II, 536

    Google Scholar 

  24. Connon, J.J.: Denol, an effective drug in the therapy of duodenal ulceration. J. Ir. Med. Assoc. 70, 206–207 (1977)

    CAS  Google Scholar 

  25. Cooke, J., Smith, J.A.: Absence of interaction of digoxin with antacids under clinical conditions. Br. Med. J. 1978 II, 1166–1167

    Google Scholar 

  26. Coughlin, G.P., Kupa, A., Alp, M.H.: The effect of tri-potassium di-citrato bismuthate (De-Nol) on the healing of chronic duodenal ulcers. Med. J. Aust. 1, 294–298 (1977)

    PubMed  CAS  Google Scholar 

  27. Crookes, J., Stevenson, I.H., Shephard, A.M.M., Muir, D.C.: The clinical significance and importance of drug interactions. In: Drug interactions. Grahame-Smith (ed.), pp. 3–13. London: Macmillan (1977)

    Google Scholar 

  28. Desmond, P.V., Pathwardhan, R.V., Schenker, S., Speeg, K.V.: Cimetidine impairs elimination of chlordiazepoxide (librium) in man. Ann. Intern. Med. 93, 266–268 (1980)

    PubMed  CAS  Google Scholar 

  29. Donovan, M.A., Heagerty, A.M., Patel, I., Castleden, M., Pohl, J.E.F.: Cimetidine and bioavailability of propranolol. Lancet 1981, 164

    Google Scholar 

  30. gestrichen

    Google Scholar 

  31. Ekenved, G., Halvorsen, L., Sölwell, L.: Influence of a liquid antacid on the absorption of different iron salts. Scand. J. Haematol. [Suppl.] 28, 65–77 (1976)

    CAS  Google Scholar 

  32. Estler, C.-J.: Arzneimittel-Interaktionen am Gastrointestinaltrakt angreifender Pharmaka. Folge 1: Azida, Antazida, Enzympräparate u.a. Fortschr. Med. 94, 1174–1176 (1976)

    PubMed  CAS  Google Scholar 

  33. Estler, C.-J.: Arzneimittel-Interaktionen am Gastrointestinalkontrakt angreifender Pharmaka. Folge 2: ParaSympathomimetika, ParaSympatholytika, Metoclopramid, Fortschr. Med. 94, 1126–1129 (1976)

    Google Scholar 

  34. Fadel, H., Elbary, A.A., El-Din, E.N., Kassem, A.A.: Availability of norethisterone acetate from combined oral contraceptive tablets. Pharmazie 34, 49–50 (1979)

    PubMed  CAS  Google Scholar 

  35. Fairfax, A.J., Adam, J., Spagan, F.S.: Effect of Cimetidine on absorption of oral benzylpenicillin. Br. Med. J. 1978, 820

    Google Scholar 

  36. Fann, W.E., Davis, J.M., Janowsky, D.S., Sekerke, H.J., Schmidt, D.M.: Chlorpromazine: Effects of antacids on its gastrointestinal absorption. J. Clin. Pharmacol. 13, 388–390 (1973)

    PubMed  CAS  Google Scholar 

  37. Feely, J., Wilkinson, G.R., Wood, A.J.J.: Reduction of liver blood flow an propranolol metabolism by Cimetidine. Engl. J. Med. 304, 692–695

    Google Scholar 

  38. Forth, W., Henschler, D., Rummel, W. (Hrsg.): Allgemeine und spezielle Pharmakologie und Toxikologie, 2. Aufl., S. 39. Mannheim:

    Google Scholar 

  39. Galeazzi, R.L.: The effect of an antacid on the bioavailability of indomethacin. Eur. J. Clin. Pharmakol. 12, 65–68 (1977)

    Article  CAS  Google Scholar 

  40. Galeazzi, R.L., Gerber, N., Iff., H.W.: Der Einfluß von Aluminium- und Magnesiumhydroxyd (Alucol) auf die Resorption von Kortison. Schweiz. Med. Wochenschr. 103, 1021–1023 (1973)

    PubMed  CAS  Google Scholar 

  41. Garty, M., Hurwitz, A.: Effect of Cimetidine on absorption of oral tetracycline in mice. Pharmacology 20, 155–159 (1980)

    Article  PubMed  CAS  Google Scholar 

  42. George, C.F.: Drug kinetics and hepatic blood flow. Clin. Pharmacokinet. 4, 443–448 (1979)

    Article  Google Scholar 

  43. Gidumal, R., Kupfersmith, J.: Drug-disease interactions: A review of the literature. Mt. Sinai J. Med. (N.Y.) 48, 7–20 (1981)

    CAS  Google Scholar 

  44. Greenblatt, D.J., Shader, R.I., Harmatz, J.S., Franke, K., Koch-Weser, J.: Influence of magnesium and aluminium hydroxide mixture on chlordiazepoxide absorption. Clin. Pharmacol. Ther. 19, 234–239 (1975)

    Google Scholar 

  45. Greenblatt, D.J., Allen, M.D., MacLaughlin, D.S., Harmatz, J.S., Shader, R.: Diazepam absorption: Effect of antacids and food. Clin. Pharmacol. Ther. 24, 600–609 (1978)

    PubMed  CAS  Google Scholar 

  46. Grote, I.W., Woods, M.: Studies on antacids. IV. Adsorption effects of various aluminum antacids upon simultaneously administered anticholinergic drugs. J. Am. Pharm. Assoc. 42, 319–320 (1952)

    Google Scholar 

  47. Harvey, S.C.: Gastric antacids and digestants. In: Goodman und Gilman’s: The pharmacological basis of therapeutics. Goodman Gillman, A., Goodman, L.S., Gilman, A. (eds.), 6th edn., pp. 988–1001. New York: 1980

    Google Scholar 

  48. Henry, D.A., MacDonald, I.A., Kitchingman, G., Bell, G.D., Langman, M.J.S.: Cimetidine and ranitidine: Comparison of effects on hepatic drug metabolism. Br. Med. J. 281, 775–777 (1980)

    Article  PubMed  CAS  Google Scholar 

  49. Hetzel,D., Birkett,D., Miners, J.: Cimetidine interaction with warfarin. Lancet 1979, 639

    Google Scholar 

  50. Hobbs, D.C., Twomey, T.M.: Piroxicam pharmacokinetics in man: Aspirin and antacid interaction studies. J. Clin. Pharmacol. 19, 270–281 (1979)

    PubMed  CAS  Google Scholar 

  51. Hurwitz, A.: Antacid therapy an drug kinetics. Clin. Pharmacokinet. 2, 269–280 (1977)

    Article  PubMed  CAS  Google Scholar 

  52. Hurwitz, A., Schlozman, D.L.: Effects of antacids on gastrointestinal absorption of isoniazid in rat and man. Am. Rev. Respir. Dis. 109, 41–47 (1974)

    PubMed  CAS  Google Scholar 

  53. Jackson, J.E., Powell, R.J., Wandell, M., Bentley, J.E., Dorr, R.: Cimetidine—theophylline interaction. Pharmacologist 22, 231 (1980)

    Google Scholar 

  54. Jefferys, D.B., Vale, J.A.: Cimetidine and bradykardia. Lancet 1978 I,, 828

    Google Scholar 

  55. Johnson, B.F., O’Grady, J., Bye, C.: The influence of digoxin particle size on absorption of digoxin and the effect of propantheline and metoclopramide. Br. J. Clin. Pharmacol. 5, 465 (1978)

    PubMed  CAS  Google Scholar 

  56. Khalil, S.A.H.: The uptake of digoxin and digitoxin by some antacids. J. Pharm. Pharmacol. 26, 961–967 (1974)

    Article  PubMed  CAS  Google Scholar 

  57. Khalil, S.A., Iwuagwu, M.: In vitro uptake of oral contraceptive steroids by magnesium trisilicate. J. Pharm. Sci. 67, 287–289 (1978)

    Article  PubMed  CAS  Google Scholar 

  58. Khalil, S.A., Daabis, N.A., Naggar, V.F., Motawi, M.M.: The in vitro adsorption of some antibiotics on antacids. Pharmazie 31, 105–109 (1976)

    PubMed  CAS  Google Scholar 

  59. Klotz, U., Reimann, I.: Delayed clearance of diazepam due to Cimetidine. N. Engl. J. Med. 302, 1012–1014 (1980)

    Article  PubMed  CAS  Google Scholar 

  60. Klotz, U., Anttila, V.-J., Reimann, I.: Cimetidine/diazepam interaction. Lancet 2, 1979 II, 699

    Google Scholar 

  61. Koch-Weser, J.: Drug therapy. Bioavailability of drugs (First of two parts). N. Engl. J. Med. 291, 733–737 (1974)

    Article  Google Scholar 

  62. Koch-Weser, J.: Drug therapy. Bioavailability of drugs (Second of the parts). N. Engl. J. Med. 291, 503–506 (1974)

    Article  PubMed  CAS  Google Scholar 

  63. Kulshrestha, V.K., Thomas, M., Wadsworth, J., Richens, A.: Interaction between Phenytoin and antacids. Br. J. Clin. Pharmacol. 6, 177–179 (1978)

    PubMed  CAS  Google Scholar 

  64. Langmann, M.J.S.: Gastrointestinal drugs. In: Side effects of drugs. Annual 4, Dukes, M.N.G. (ed.), pp. 252–257. Amsterdam: 1980

    Google Scholar 

  65. Lee, D.A.H., Taylor, G.M., Walker, J.G., James, V.H.T.: The effect of concurrent administration of antacids on prednisolone absorption. Br. J. Clin. Pharmacol. 8, 92–94 (1979)

    PubMed  CAS  Google Scholar 

  66. Levy, G., Lampman, T., Kamath, B.L., Garrettson, L.K.: Decreased serum salicylate concentrations in children with rheumatic fever treated with antacid. N. Engl. J. Med. 293, 323–325 (1975)

    Article  PubMed  CAS  Google Scholar 

  67. gestrichen

    Google Scholar 

  68. Lucarotti, R.L., Colaizzi, J.L., Barry, H., Poust, R.J.: Enhanced aboudoephedrine absorption by concurrent administration of aluminium hydroxide gel in humans. J. Pharm. Sci. 61, 903–905 (1972)

    Article  PubMed  CAS  Google Scholar 

  69. Ma, K.W., Brown, D.C., Masler, D.S., Silvis, S.E.: Effects of renal failure on blood levels of Cimetidine. Gastroenterology 74, 473–477 (1978)

    PubMed  CAS  Google Scholar 

  70. Marks, J.N.: Current therapy in peptic ulcer. Drugs 20, 283–299 (1980)

    Article  PubMed  CAS  Google Scholar 

  71. McElnay, J.C., Harron, D.W.G., D’Arcy, P.F., Collier, P.S.: Interaction of warfarin with antacid constituents. Br. Med. J. 1978 II, 1166

    Google Scholar 

  72. Melmon, K.L., Gilman, A.G.: Drug interactions. In: Goodman and Gilman’s: The pharmacological basis of therapeutics. Goodman, A., Gilman, Goodman, L.S., Gil- man, A. (eds.), pp. 1737–1740. New York: 1980

    Google Scholar 

  73. Melmon, K.L., Nierenberg, D.W.: Drug interactions and the prepared observer. N. Engl. J. Med. 304, 723–725 (1981)

    Article  PubMed  CAS  Google Scholar 

  74. Meyer, U.A.: Welche Arzneimittelwechsel Wirkungen sind klinisch relevant? Internist (Berlin) 20, 251–256 (1979)

    CAS  Google Scholar 

  75. Morris, T., Rhodes, J.: Antacids and peptic ulcer—a reappraisal. Gut 20, 538–545 (1979)

    Article  PubMed  CAS  Google Scholar 

  76. Morrison, P.J., Rogers, HJ., Bradbrook, I.D.: Concurrent administration of Cimetidine and enteric-coated prednisolone: Effect on plasman levels of prednisolone. Br. J. Clin. Pharmacol. 10, 87–89 (1980)

    PubMed  CAS  Google Scholar 

  77. Naggar, V.F., Khalil, S.A., Daabis, N.A.: The in-vitro adsorption of some antirheumatics on antacids. Pharmazie 31, 461–465 (1976)

    PubMed  CAS  Google Scholar 

  78. Naggar, V.F., Gouda, M.W., Khalil, S.A.: In vitro adsorption of some corticosteroids on antacids. Pharmazie 32, 778–781 (1977)

    PubMed  CAS  Google Scholar 

  79. Naggar, V.F., Khalil, S.A., Gouda, M.W.: Effect of concomitant administration of magnesium trisilicate on GI absorption of dexamethasoue in humans. J. Pharm. Sei. 67, 1029–1030 (1978)

    Article  CAS  Google Scholar 

  80. Nair, S.G., Gamble, J.A.S., Dundee, J.W., Howard, P.J.: The influence of three antacids on the absorption and clinical action of oral diazepam. Br. J. Anaesth. 48, 1175–1180 (1976)

    Article  PubMed  CAS  Google Scholar 

  81. Nair, S.G., Gamble, J.A.S., Dundee, J.W., Howard, P.J.: New drugs for peptic ulcer. Br. Med. J. 1980 II, 95–96

    Google Scholar 

  82. O’Brien, L.S., Orme, M.L’E., Breckenridge, A.M.: Failure of antacids to alter the pharmacokinetics of phenytoin. Br. J. Clin. Pharmacol. 6, 176–177 (1978)

    PubMed  Google Scholar 

  83. Ohnhaus, E.E.: The effect of antacid and food on the absorption of proquazone (biarison) in man. Int. J. Clin. Pharmacol. Ther. Toxicol. 18, 136–139 (1980)

    PubMed  CAS  Google Scholar 

  84. Orme, M.L’E., Serlin, M.J.: Avoiding drug interactions during oral anticoagulant therapy. Adverse Drug Reaction Bull 81, 292–295 (1980)

    Article  Google Scholar 

  85. Pathwardhan, R.V., Yarborough, G.W., Desmond, P.V., Johnson, R.F., Schenker, S., Speeg, K.V.: Cimetidine spares the glucuronidation of lorazepam and oxazepam. Gastroenterology 79, 912–916 (1980)

    Google Scholar 

  86. Peterson, W.L., Sturdevant, R.A.L., Frankl, H.D. et al.: The healing of duodenal ulcer with an antacid regimen. N. Engl. J. Med. 297, 341 (1977)

    Article  PubMed  CAS  Google Scholar 

  87. Piper, D.W., Kang, J.: Which antacid? Drugs 17, 124–128 (1979)

    Article  PubMed  CAS  Google Scholar 

  88. Puurunen, J., Pelkonen, O.: Cimetidine inhibits microsomal drug metabolism in the rat. Eur. J. Pharmacol. 55, 335–336 (1979)

    Article  PubMed  CAS  Google Scholar 

  89. Rendić, S., Sunjic, V., Toso, R., Kajfez, F.: Interaction of Cimetidine with liver microsomes. Xenobiotica 9, 555–564 (1979)

    Article  PubMed  Google Scholar 

  90. Rogers, H.J., House, F.R., Morrison, P.J., Bradbook, I.D.: Interaction of Cimetidine with tetracycline absorption. Lancet 1980 II, 694

    Google Scholar 

  91. Rogers, H.J., James, C.A., Morrison, P.J., Bradbook, I.D.: Effect of Cimetidine on oral absorption of ampicillin and cotrimoxazole. J. Antimicrob. Chemother. 6, 297–300 (1980)

    Article  PubMed  CAS  Google Scholar 

  92. Romankiewicz, J.A.: Effects of antacids on gastrointestinal absorption of drugs. Primary Care 3, 537–550 (1976)

    PubMed  CAS  Google Scholar 

  93. Ruffalo, R.L., Thompson, J.F.: Effect of Cimetidine on the clearance of benzodiazepines. N. Engl. J. Med. 303, 753–754 (1980)

    Article  PubMed  CAS  Google Scholar 

  94. Segre, E.J., Sevelius, H., Varady, J.: Effects of antacids on naproxen absorption. N. Engl. J. Med. 291, 582–583 (1974)

    PubMed  CAS  Google Scholar 

  95. Sehrt, U.: Pharmakotherapie, S. 65. München: M.M.W. Medizin-Verlag 1980

    Google Scholar 

  96. Serlin, M.J., Sibeon, R.G., Mossman, S., Breckenridge, A.M.: Cimetidine: Interaction with oral anticoagulants in man. Lancet 1979 II, 318–349

    Google Scholar 

  97. Silver, B.A., Bell, W.R.: Cimetidine potentiation of the hypothrombinemic effect of warfarin. Ann. Intern. Med. 90, 384 (1978)

    Google Scholar 

  98. Staiger, C., Simon, B., de Vries, J., Walter, E.: Untersuchungen zur Wirkung von Ranitidin auf den Antipyrin-Metabolismus. Z. Gastroenterol. 18, 601–604 (1980)

    PubMed  CAS  Google Scholar 

  99. Steinberg, W., King, C., Toskes, P.: Cimetidine inhibits the absorption of protein- bound vitamin B 12 but not crystalline vitamin B 12. Gastroenterology 74, 1099 (1978)

    Google Scholar 

  100. Tanner, A.R., Caffin, J.A., Halliday, J.W., Powell, L.W.: Concurrent administration of antacids and prednisone: Effect on serum levels of prednisolone. Br. J. Clin. Pharmacol. 7, 397–400 (1979)

    PubMed  CAS  Google Scholar 

  101. Thornton, P.C., Papouchado, M., Reed, P.I.: Carbenoxolone interactions in man—preliminary report. Carbenoxolone Symposium, Scand. J. Gastroenterol. (1981)

    Google Scholar 

  102. Uribe, M., Casian, C., Rojas, S., Sierra, J.G., Go, V.L.: Decreased bioavailability of prednisone due to antacids in patients with chronic active liver disease and in healthy volunteers. Gastroenterology 80, 661–665 (1981)

    PubMed  CAS  Google Scholar 

  103. Verbeeck, R., Tjandramaga, T.B., Mullie, A., Verbesselt, R., de Schepper, P.J.: Effect of aluminum hydroxide on diflunisal absorption. Br. J. Clin. Pharmacol. 7, 519–522 (1979)

    PubMed  CAS  Google Scholar 

  104. Vöhringer, H.-F., Kuhlmann, J., Rietbrock, N.: Der Einfluß von Antacida auf die Plasmakonzentration von Digoxin beim Menschen. Dtsch. Med. Wochenschr. 101, 106–108 (1976)

    Article  PubMed  Google Scholar 

  105. Waisbren, B.A., Hueckel, J.S.: Reduced absorption of aureomycin caused by aluminum hydroxide gel (amphojel). Proc. Soc. Exp. Biol. Med. 73, 73–74 (1950)

    PubMed  CAS  Google Scholar 

  106. Walkenstein, S.S., Dubb, J.W., Randolph, W.C., Westlake, W.J., Stote, R.M., Intoccia, A.P.: Bioavailability of Cimetidine in man. Gastroenterology 74, 360–365 (1978)

    PubMed  CAS  Google Scholar 

  107. Wallin, B.A., Jacknowitz, A., Raich, P.C.: Cimetidine and effect of warfarin. Ann. Intern. Med. 90, 993 (1979)

    PubMed  CAS  Google Scholar 

  108. Weinberger, M.M., Smith, G., Milavetz, G., Hendeles, L.: Decreased theophylline clearance due to Cimetidine. N. Engl. J. Med. 304, 672 (1981)

    PubMed  CAS  Google Scholar 

  109. Wilkinson, C.F., Hetnarski, K., Hicks, L.J.: Substituted imidazoles as inhibitors of microsomal oxidation and insecticide synergists. Pestic. Biochem. Physiol. 4, 299–312 (1974)

    Article  CAS  Google Scholar 

  110. Wilkinson, G.R., Shand, D.G.: A physiological approach to hepatic drug clearance. Clin. Pharmacol. Ther. 18, 377–390 (1975)

    PubMed  CAS  Google Scholar 

  111. Wing, L.M.H., Meffin, P.J., Grygiel, J.J., Smith, K.J., Birkett, D.J.: The effect of metoclopramide and atropine on the absorption of orally administered mexiletine. Br. J. Clin. Pharmacol. 9, 505–509 (1980)

    PubMed  CAS  Google Scholar 

  112. Knodell, R.G., Holtzman, J.L., Crankshaw, D.L., Steele, N.M., Stanley, L.N.: Drug metabolism by rat and human hepativ microsomes in response to interaction with H2- receptor antagonists. Gastroenterology 82, 84–88 (1982).

    PubMed  CAS  Google Scholar 

  113. Speeg, K.V., Pathwardhan, R.V., Avant, G.R., Mitchell, M.C., Schenker, S.: Inhibition of microsomal drug metabolism by histamine H2-receptor antagonists studied in vivo and in vitro in rodents. Gastroenterology 82, 89–96 (1982)

    PubMed  CAS  Google Scholar 

  114. Jackson, E.J.: Reduction of liver blood flow by Cimetidine. New England Journal of Medicine 105, 99–100 (1981)

    Google Scholar 

  115. Lebrec, D., Goldfarb, G., Benhamou, J.: Reduction of liver blood flow by Cimetidine. New England Journal of Medicine 105, 100–101 (1981)

    Google Scholar 

  116. Lam, A.M.: Potentially lethal interaction of Cimetidine and morphine (letter). The Canadian Medical Association 125/8, 820 (1981)

    Google Scholar 

  117. Shaw, G., Bury, R.W., Mashford, M.L., Breen, K.J., Desmond, P.V.: Cimetidine impairs the elimination of Chlormethiazole. Eur. J. Clin. Pharmacol. 21, 83–85 (1981)

    Article  PubMed  CAS  Google Scholar 

  118. Harenberg, J., Zimmermann, R., de Vries, J., Walter, E., Weber, E.: Pharmacodynamics of Marcumar (phenprocoumone) during concomitant treatment with Tagamet (Cimetidine) (in Vorbereitung)

    Google Scholar 

  119. Streeter, A.M., Goulston, K.J., Bathur, F.A., Hilmer, R.S., Crance, G.G., Pheils, M.T.: Cimetidine and malabsorption of cobalamin. Digestive Dieseases and Sciences 27, 13–16 (1982)

    Article  CAS  Google Scholar 

  120. Gugler, R., Brand, M., Somogyi, A.: Impaired Cimetidine absorption due to antacids and metoclopramide. Eur. J. Clin. Pharmacol 201, 225–228 (1981)

    Article  Google Scholar 

  121. Normann, S., Russell, W., Guild, R., Doering, P., Lopez, L.: Some effects of mylanta II and bicarbonate on Cimetidine absorption (abstr.). Gastroenterology 82, 1138 (1982)

    Google Scholar 

  122. Khoury, W., Geraci, K., Askari, A., Johnson, M.: The Effect of Cimetidine on aspirin absorption. Gastroenterology 5, 1169 (1976)

    Google Scholar 

  123. Jordaens, L., Hoegarts, J., Belpaire, F.: Non-interaction of Cimetidine with digoxin absorption. Acta Clin. Belg. 36 (2), 109–110 (1981)

    PubMed  CAS  Google Scholar 

  124. Ochs, R., Gugler, R., Guthoff, T., Greenblatt, D.J.: Effect of Cimetidine on digoxin kinetics and creatinine clearance (in Vorbereitung)

    Google Scholar 

  125. Feely, J., Guy, E.: Ranitidine also reduces liver blood flow. The Lancet 1, 169 (1982)

    Article  Google Scholar 

  126. Steinberg, W.M., Lewis, J.H., Katz, D.M.: Antacids inhibit absorption of Cimetidine. New England Journal of Medicine 307, 400–404 (1982)

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. C. J. Fimmel
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  2. H. Lorenz-Meyer
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Editors and Affiliations

  1. Medizinische Klinik, Stadtspital Triemli, Birmensdorferstraße 497, CH-8063, Zürich, Switzerland

    André Louis Blum

  2. Klinikum rechts der Isar, der Technischen Universität München, Ismaninger Straße 22, D-8000, München 80, Germany

    Jörg Rüdiger Siewert (Direktor der Chirurgischen Klinik und Poliklinik) (Direktor der Chirurgischen Klinik und Poliklinik)

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© 1982 Springer-Verlag Berlin Heidelberg

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Fimmel, C.J., Lorenz-Meyer, H. (1982). Interaktionen von Ulcustherapeutica. In: Blum, A.L., Siewert, J.R. (eds) Ulcus-Therapie. Interdisziplinäre Gastroenterologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68477-7_25

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  • DOI: https://doi.org/10.1007/978-3-642-68477-7_25

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-68478-4

  • Online ISBN: 978-3-642-68477-7

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