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Peptides: Pancreatic Hormones

  • Chapter
Mediators and Drugs in Gastrointestinal Motility II

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 59 / 2))

Abstract

The pancreatic hormone glucagon, well known essentially for its metabolic effects, has also been used as a pharmacologic tool in different conditions: as a provocative test for pheochromocytoma, as a stimulus for growth hormone release, in the treatment of uncomplicated insulin-induced and sulfonylurea-induced hypoglycemia, and in some cases of acute heart failure in which myocardial tissue is essentially healthy. From a chemical point of view glucagon is a member of the so-called secretin family and it shares 14 positionally identical amino acids with secretin (see Table 1 in Chap. 2a, Secretin), suggesting that these two peptides may have a common ancestral gene and that their structure may contain a still undeciphered message of phylogenetic and physiologic significance (for reviews see Lefebvre and Unger 1972; Foà et al. 1977). No wonder that their effects have so many points in common: both stimulate the secretion of insulin, inhibit gastric secretion, and exert a predominant inhibitory effect on gastrointestinal motility. This latter effect will be described in detail.

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References

  • Anuras S, Cooke RA (1978) Effects of some gastrointestinal hormones on two muscle layers of duodenum. Am J Physiol 234: E60–E63

    PubMed  CAS  Google Scholar 

  • Behar J (1978) Effect of glucagon on the feline lower esophageal sphincter (LES) in vivo. Gastroenterology 74: A1116

    Google Scholar 

  • Behar J, Field S, Marin C (1979) Effect of glucagon, secretin, and vasoactive intestinal polypeptide on the feline lower esophageal sphincter: mechanism of action. Gastroenterology 77: 1001–1007

    PubMed  CAS  Google Scholar 

  • Bertrand G, Linscheer WG, Raheja KL, Woods RE (1977) Double-blind evaluation of glucagon and propantheline bromide (probanthine) for hypotonie duodenography. Am J R oen tgen o l 128: 197–200

    CAS  Google Scholar 

  • Bloom SR, Polak JM (1978) Gut hormone overview. In: Bloom SR (ed) Gut hormones. Churchill Livingstone, Edinburgh London, pp 3–18

    Google Scholar 

  • Bortolotti M, Sanavio C, Sansone G, Lab() G (1975) Modifications in human gastric motility induced by secretin and by glucagon. Rend Gastroenterol 7: 240

    Google Scholar 

  • Cameron AJ, Phillips SF, Summerskill WHJ (1970) Comparison of effects of gastrin, cholecystokinin-pancreozymin, secretin, and glucagon on human stomach muscle in vitro. Gastroenterology 59: 539–545

    PubMed  CAS  Google Scholar 

  • Carsen GM, Finby N (1976) Hypotonie duodenography with glucagon. A clinical comparison study. Radiology 118: 529–533

    Google Scholar 

  • Chernish SM, Miller RE, Rosenak BD, Schulz NE (1972) Hypotonie duodenography with the use of glucagon. Gastroenterology 63: 392–398

    PubMed  CAS  Google Scholar 

  • Chernish SM, Brunelle RR, Rosenak BD, Ahmadzai S (1978a) Comparison of the effects of glucagon and atropine sulfate on gastric emptying. Am J Gastroenterol 70: 581–586

    CAS  Google Scholar 

  • Chernish SM, Miller RE, Brunell RL, Rosenak BD (1978b) Dose-response to intravenous glucagon as measured by roentgenography. Radiology 127: 55–59

    Google Scholar 

  • Chowdhury AR, Lorber SH (1975) Effect of glucagon on cholecystokinin and prostigmininduced motor activity of the distal colon and rectum in humans. Gastroenterology 68: 875

    Google Scholar 

  • Chowdhury AR, Lorber SH (1977) Effects of glucagon and secretin on food-or morphine-induced motor activity of the distal colon, rectum, and anal sphincter. Dig Dis Sci 22: 775–780

    CAS  Google Scholar 

  • Christiansen J, Borgeskov S (1974) The effect of glucagon and the combined effect of glucagon and secretin on lower esophageal sphincter pressure in man. Scand J Gastroenterol 9: 615–618

    PubMed  CAS  Google Scholar 

  • Christiansen J, Lauritzen K, Moesgaard J, Holst JJ (1977) Effect of endogenous and exogenous glucagon on pentagastrinstimulated lower esophageal sphincter pressure in man. Scand J Gastroenterol 12: 33–36

    PubMed  CAS  Google Scholar 

  • Cohen ML, Wiley KS, Yaden E, Slater IH (1979) In vitro actions of somatostatin, D-Val’Trp8-somatostatin and glucagon in rabbit jejunum and guinea pig ileum. J Pharmacol Exp Ther 211:423–429

    PubMed  CAS  Google Scholar 

  • Corazziari E (1976) Mechanical activity of the second portion of human duodenum. Rend Gastroenterol 8: 64

    Google Scholar 

  • Doteval G, Koch NG (1963) The effect of glucagon on intestinal motility in man. Gastroenterology 45: 364–367

    Google Scholar 

  • Egberts EH, Johnson AG (1977) The effect of cholecystokinin on human taenia coli. Digestion 15: 217–222

    PubMed  CAS  Google Scholar 

  • Evans DF, Foster GE, Hardcastle JD, Johnson F, Wright J (1978) The effect of glucagon on the canine duodenum and small intestine. Br J Pharmacol 64: 475 P

    Google Scholar 

  • Fasth S, Hulten L (1971) The effect of glucagon on intestinal motility and blood flow. Acta Physiol Scand 83: 169–173

    PubMed  CAS  Google Scholar 

  • Ferrucci JT, Long JA (1977) Radiologie treatment of esophageal food impacting using intravenous glucagon. Radiology 125: 25–28

    PubMed  Google Scholar 

  • Foà PP, Bajaj JS, Foà NL (eds) (1977) Glucagon: its role in physiology and clinical medicine. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Foster GE, Hardcastle JD, Evans DF, Wright J, Johnson F (1979) Action of glucagon on the human and canine duodenum. Gut 20: A439–A440

    Google Scholar 

  • García-Vilar R Recherches sur la motricité colique chez le chien. Master’s thesis, Institut National Polytechnique de Toulouse, pp 1–136

    Google Scholar 

  • Gardner JD, Malloy RG, Hogan WJ (1973) Pentagastrin and glucagon effects on the internal anal sphincter pressure in man. Clin Res 21: 826

    Google Scholar 

  • Gerner T, Haffner JFW (1975) The significance of distention for the effect of glucagon on the fundic and antral motility in isolated guinea-pig stomach. Scand J Gastroenterol 10: 51–53

    Google Scholar 

  • Gerner T, Haffner JFW (1978) The inhibitory effect of secretin and glucagon on pressure responses to cholecystokinin-pancreozymin in isolated guinea-pig stomach. Scand J Gastroenterol 13: 537–544

    PubMed  CAS  Google Scholar 

  • Gohel VK, Dalinka MK, Coren GS (1975) Hypotonie examination of the colon with glucagon. Radiology 115: 1–4

    PubMed  CAS  Google Scholar 

  • Granata L, Leone D, Paccione F, Ruccia D (1974) Effetti del glucagone sulla motilità del digiuno nel cane non narcotizzato. Boll Soc Ital Biol Sper 50: 780–785

    PubMed  CAS  Google Scholar 

  • Harned RK, Stelling CB, Williams S, Wolf GL (1976) Glucagon and barium enema examinations: a controlled clinical trial. Am J Roentgenol 126: 981–984

    CAS  Google Scholar 

  • Hecht HL, Hollenberg GM, Pradham AR (1979) Glucagon-induced small intestinal hy-potonie demonstrating bleeding lymphoma. Gastrointest Radiol 4: 61–63

    PubMed  CAS  Google Scholar 

  • Hicks T, Turnberg LA (1974) Influence of glucagon on the human jejunum. Gastroenter-ology 67: 1114–1118

    CAS  Google Scholar 

  • Hogan WJ, Dodds WJ, Hoke SE, Reid DP, Kalkhoff RK, Arndorfer RC (1975) Effect of glucagon on esophageal motor function. Gastroenterology 69: 60–65

    Google Scholar 

  • Holst JJ (1978) Physiology of enteric glucagon-like substances. In: Bloom SR (ed) Gut hormones. Churchill Livingstone, London Edinburgh, pp 383–386

    Google Scholar 

  • Hradsky M, Stockbrügger R, Oestberg H (1973) The effect of glucagon on gastric motility, the pylorus and reflux of bile into the stomach during gastroscopie examination. Scand J Gastroenterol [Suppl 20] 8: 26

    Google Scholar 

  • Ihasz M, Koiss I, Németh EP, Folly G, Papp M (1976) Action of caerulein, glucagon or prostaglandin E, on the motility of intestinal villi. Pfluegers Arch 364: 301–304

    CAS  Google Scholar 

  • Jaffer SS, Makhlouf GM, Schorr BA, Zfass AM (1974) Nature and kinetics of inhibition of lower esophageal sphincter pressure by glucagon. Gastroenterology 67: 42–46

    PubMed  CAS  Google Scholar 

  • Jennewein HM, Waldeck F, Siewert R, Weiser F, Thimm R (1973) The interaction of glucagon and pentagastrin on the lower oesophageal sphincter in man and dog. Gut 14: 861–864

    PubMed  CAS  Google Scholar 

  • Kill J, Andersen D, Weinreich J (1976) A double-blind comparison of gastric relaxation after buscopan and glucagon Novo. Scand J Gastroenterol [Suppl 38] 11: 58

    Google Scholar 

  • Koch NG, Darle N, Doteval G (1967) Inhibition of intestinal motility in man by glucagon given intraportally. Gastroenterology 53: 88–92

    Google Scholar 

  • Kowalewski K, Kolodej A (1975) Effect of glucagon on myoelectrical activity recorded from the isolated homologous perfused canine stomach. Arch Int Pharmacodyn Ther 218: 186–195

    PubMed  CAS  Google Scholar 

  • Kowalewski K, O’Sullivan G, Kolodej A (1976) Effect of glucagon on myoelectrical and mechanical activity of the isolated homologous perfused porcine stomach. Pharmacology 14: 115–124

    PubMed  CAS  Google Scholar 

  • Labò G, Bortolotti M (1976) Effect of gut hormones on myoelectric and manometric activity of the duodenum in man. Rend Gastroenterol 8: 64

    Google Scholar 

  • Lefebvre PJ, Luyckx AS (1978) Gastric-glucagon: physiology and pathology. In: Grossman M, Speranza V, Basso N, Lezoche E (eds) Gastrointestinal hormones and pathology of the digestive system. Plenum, New York, pp 173–181

    Google Scholar 

  • Lefebvre PJ, Unger RH (1972) Glucagon. Pergamon, Oxford

    Google Scholar 

  • Lin TS (1980) Effects of insulin and glucagon on secretory and motor function of the gastrointestinal tract. In: Jerzy Glass GB (ed) Gastrointestinal Hormones. Raven, New York, pp 639–691

    Google Scholar 

  • Meeroff JC, Jorgens J, Isenberg JI (1975) The effect of glucagon on barium-enema examination. Radiology 115: 5–7

    PubMed  CAS  Google Scholar 

  • Meves M, Beger HG, Hüthwohl B (1975) The effect of some gastrointestinal hormones on gastric evacuation in man. In: Vantrappen G (ed) Fifth International Symposium on Gastrointestinal Motility. Typoff, Herentals, pp 76–81

    Google Scholar 

  • Miller RE, Chernish SM, Skucas J, Rosenak BD, Rodda BE (1974a) Hypotonic roent-genography with glucagon. Am J Roentgenol Radium Ther Nuc Med 121: 264–274

    CAS  Google Scholar 

  • Miller RE, Chernish SM, Skucas J, Rosenak BD, Rodda BE (1974b) Hypotonic colon ex-amination with glucagon. Radiology 113: 555–562

    PubMed  CAS  Google Scholar 

  • Miller RE, Chernish SM, Brunelle RL, Rosenak BD (1978a) Dose response to intramuscular glucagon during hypotonic radiography. Radiology 127: 49–53

    PubMed  CAS  Google Scholar 

  • Miller RE, Chernish SM, Brunelle RL, Rosenak BD (1978b) Double-blind radiographic study of dose-response to intravenous glucagon for hypotonie duodenography. Radiology 127: 55–59

    PubMed  CAS  Google Scholar 

  • Miolan JP, Roman C (1975) Mechanisms of the inhibitory effect of glucagon on gastric motility. In: Vantrappen G (ed) Fifth International Symposium on Gastrointestinal Motility. Typoff, Herentals, pp 70–75

    Google Scholar 

  • Mlecko LM (1974) Hypotonie duodenoscopy using glucagon. Gastroenterology 66:A164/ 818

    Google Scholar 

  • Necheles H, Sporn J, Walker L (1966) Effect of glucagon on gastrointestinal motility. Am J Gastroenterol 45: 34–39

    PubMed  CAS  Google Scholar 

  • Nicolov NA, Deleva JI (1977) Effects of glucagon on the motor and mio-electrical activity of the gastrointestinal tract in dogs. Riv Farmacol Ter 8: 275–280

    CAS  Google Scholar 

  • Patel GK, Whalen GE, Soergel KH, Wu WC, Meade RC (1979) Glucagon effects on the human small intestine. Dig Dis Sci 24: 501–508

    PubMed  CAS  Google Scholar 

  • Phaosawasdi K, Boden G, Kolts B, Fisher RS (to be published) Hormonal effects on pyloric sphincter pressure: are they of physiological importance? Clin Res

    Google Scholar 

  • Pillari G, Bank S, Katzka I, Fulco JD (1979) Meat bolus impaction of the lower esophagus associated with a paraesophageal hernia. Successful noninvasive treatment with intravenous glucagon. Am J Gastroenterol 71: 287–289

    Google Scholar 

  • Ratcliffe JF (1980) Glucagon in barium examination in infants and children: special reference to dosage. Br J Radiol 53: 860–862

    PubMed  CAS  Google Scholar 

  • Scott LD, Summers RW (1976) Correlation of contractions and transit in rat small intestine. Am J Physiol 230: 132–137

    PubMed  CAS  Google Scholar 

  • Siegel SR, Brown FC, Castell DO, Johnson LF, Said SI (1979) Effects of vasoactive intestinal polypeptide ( VIP) on lower esophageal sphincter in awake baboons-comparison with glucagon and secretin. Dig Dis Sci 24: 345–349

    PubMed  CAS  Google Scholar 

  • Stunkard SJ, Van Itallie TB, Reis BB (1955) The mechanism of satiety. Effect of glucagons on gastric hunger contraction in man. Proc Soc Exp Biol Med 89: 258–261

    PubMed  CAS  Google Scholar 

  • Taylor I, Duthie HL, Cumberland DC, Smallwood R (1975a) Glucagon and the colon. Gut 16: 973–978

    CAS  Google Scholar 

  • Taylor I, Duthie HL, Smallwood R ( 1975 b) The effect of glucagon on colonic myoelectric activity. In: Vantrappen F (ed) Fifth International Symposium on Gastrointestinal Motility. Typoff, Herentals, pp 76–81

    Google Scholar 

  • Tolin RD, Boden G, Fisher RS (1979) Effects of endogenous hyperglucagonemia on lower esophageal sphincter pressure and gastric acid secretion. Dig Dis Sci 24: 296–304

    PubMed  CAS  Google Scholar 

  • Unger RH, Eisentraut A, Sims K, McCall MS, Madison LL (1961) Sites of origin of glu-cagon in dogs and humans. Clin Res 9: 53

    Google Scholar 

  • Valenzuela JE (1976) Effect of intestinal hormones and peptides on intragastric pressure in dogs. Gastroenterology 71: 766–769

    PubMed  CAS  Google Scholar 

  • Vecchioli A, Aluffi A, Parrella RE, Colagrande C (1977) Glucagon in gastric and duodenal roentgenology. In: Speranza V, Basso N, Lezoche E (eds) Int Symp Gastrointestinal Horm and Pathol Dig Syst, Rome, June 13–15, 1977. Arti Grafiche Tris, Rome, p 104

    Google Scholar 

  • Waldeck F, Siewert R, Jennewein HM, Weiser F (1973) Das Druckprofil im unteren Ösophagussphinkter beim Menschen und seine Beeinflussung durch Gastrin, Calcitonin und Glucagon. Dtsch Med Wochenschr 98: 1059–1063

    Google Scholar 

  • Watanabe O, Atobe Y, Atsutaka Mori K, Akagi M, Nishi K (1979) Effects of feeding and glucagon on electrical activity of the stomach in the conscious dog: Proc 8th Symposium on Pharmacological Activity and Mechanism, Kumamoto, Oct. 25–26. p S-4

    Google Scholar 

  • Whalen GA (1974) Glucagon and the small gut. Gastroenterology 67: 1284–1286

    PubMed  CAS  Google Scholar 

  • Wingate DL, Pearce EA, Thomas PA, Boucher BJ (1978) Glucagon stimulates intestinal myoelectric activity. Gastroenterology 74: A1152

    Google Scholar 

  • Adrian TE, Besterman HS, Christofides ND, Bloom SR (1978) Interaction of gastrointestinal hormones and cholinergic innervation on the release of pancreatic polypeptide. Scand J Gastroenterol [Suppl 49] 13: 1

    Google Scholar 

  • Ali TM, Nicholson T, Singleton AG (1976) Stomach motility in insulin-treated sheep. Q J Exp Physiol 61: 321–329

    CAS  Google Scholar 

  • Arnqvist HJ (1974) Action of insulin on vascular and intestinal smooth muscle. Effects on aminoacid transport, protein synthesis, and accumulation of glucose carbon. Acta Physiol Scand 90: 132–142

    PubMed  CAS  Google Scholar 

  • Arnqvist HJ, Lundstrom B (1976) Effects of insulin on human intestinal smooth muscle. Acta Endocrinol [Suppl 203] 82: 10

    Google Scholar 

  • Bachrach WH (1953) Action of insulin hypoglycemia on motor and secretory functions of the digestive tract. Physiol Rev 33: 566–592

    PubMed  CAS  Google Scholar 

  • Barlow OW (1931) Effect of insulin on perfused heart and on isolated rabbit intestine. J Pharmacol Exp Ther 41: 217–228

    CAS  Google Scholar 

  • Bogach PG, Nga CS, Groisman SD (1973) Effect of insulin hypoglycemia on the motility of the dog jejunum and ileum. Fiziol Zh 19: 471–476

    PubMed  CAS  Google Scholar 

  • Bogach PG, Groisman SD, Chan SN (1974) Effect of varying degree of parasympathetic denervation of the stomach, the duodenum and the jejunum on the motor reactions induced by insulin hypoglycemia. Fiziol Zh SSSR 60: 1446–1453

    PubMed  CAS  Google Scholar 

  • Bowen JM (1962) Effect of insulin hypoglycemia on gastrointestinal motility in the sheep. Am J Vet Res 23: 948–954

    PubMed  CAS  Google Scholar 

  • Bueno L, Ruckebusch Y (1975) Evidence for a role of endogenous insulin on intestinal motility. In: Vantrappen G (ed) Fifth International Symposium on Gastrointestinal Motility. Typoff, Leuven, pp 64–69

    Google Scholar 

  • Bueno L, Ruckebusch M (1976) Insulin and jejunal electrical activity in dogs and sheep. Am Physiol 230: 1538–1544

    CAS  Google Scholar 

  • Bulatao E, Carlson AJ (1924) Influence of experimental changes in blood sugar levels on gastric hunger contraction. Am J Physiol 69: 108–115

    Google Scholar 

  • Castell DO (1971) Changes in lower esophageal sphincter pressure during insulin-induced hypoglycemia. Gastroenterology 61: 10–15

    PubMed  CAS  Google Scholar 

  • Christensen NJ (1974) Plasma norepinephrine and epinephrine in untreated diabetics during fasting and after insulin administration. Diabetes 23: 1–8

    PubMed  CAS  Google Scholar 

  • Code CF (1956) Histamine and gastric secretion. Ciba Foundation Symposium. In: Wolstenholme GEW, O’Connor CM (eds) Histamine. Churchill Livingstone, Edinburgh London, pp 189–219

    Google Scholar 

  • De Fronzo RA, Andres R, Bledsoe TA, Boden G, Faloona GA, Tobin JD (1977) A test of the hypothesis that the rate of fall in glucose concentration triggers counterregulatory hormonal responses in man. Diabetes 26: 445–452

    Google Scholar 

  • Felber JP, Dick J (1975) L’axe entéro-pancréatique. Med Hyg 33: 82–83

    Google Scholar 

  • Feldman M, Morrison S (1948) The effect of insulin on motility of the stomach following bilateral vagotomy. Am J Dig Dis 15: 175A

    Google Scholar 

  • Garcia-Vilar R (1979) Recherches sur la motricité colique chez le chien. Master’s Thesis, Institut National Polytechnique de Toulouse, pp 1–136

    Google Scholar 

  • Goyal RK, Rattan S (1978) Neurohumoral, hormonal, and drug receptors for the lower esophageal sphincter. Gastroenterology 74: 598–619

    PubMed  CAS  Google Scholar 

  • Grossman MI (1971) How does insulin stimulate the lower esophageal sphincter? Gastroenterology 61: 119–120

    PubMed  CAS  Google Scholar 

  • Gzgzyan DM, Kuzina MM (1973) Stomach motor activity in the black sea ray Daeyatis paetinaca. Zh Evol Biokhim Fiziol 9: 536–539

    CAS  Google Scholar 

  • Gzgzyan DM, Kuzina M, Tanaschuk OF (1973) The effect of hypophysical hormons and insulin on motor activity of the stomach in the scorpion fish Scorpaena porpus. Zh Evol Biokhim Fiziol 9: 301–303

    CAS  Google Scholar 

  • Heinz TE, Palmer WL (1930) A study of the effect of insulin on gastric motility. Proc Soc Exp Biol Med 27: 1047–1049

    Google Scholar 

  • Hill KJ (1954) Insulin hypoglycemia and gastric motility in the sheep. Q J Exp Physiol 39: 253–260

    CAS  Google Scholar 

  • Jahnberg T, Abrahamson H, Jansson G, Martinson J (1977) Gastric relaxation response to insulin before and after vagotomy. Scand J Gastroenterol 12: 229–233

    PubMed  CAS  Google Scholar 

  • Kahlson G, Rosengren E, Svahn D, Thunberg R (1964) Mobilization and formation of histamine in the gastric mucosa as related to gastric secretion. J Physiol (Lond) 174: 400–416

    CAS  Google Scholar 

  • Kaneto A, Miki E, Kosaka K (1974) Effects of vagal stimulation on glucagon and insulin secretion. Endocrinology 95: 1005–1010

    PubMed  CAS  Google Scholar 

  • Killenberg PG, Cornwell GG (1964) Effect of insulin hypoglycemia on the human sigmoid colon. Am J Dig Dis 9: 221–228

    PubMed  CAS  Google Scholar 

  • Kleitsch WP, Puestow CB (1939) Studies of intestinal motility: the effect of intravenous solutions and of insulin upon peristalsis. Surgery 6: 687–696

    Google Scholar 

  • La Barre J (1931) Influence of insulin hypoglycemia of the central nervous system on gastric motility. C R Soc Biol (Paris) 107: 258–260

    Google Scholar 

  • La Barre J, Destree P (1930) Role des centres nerveux supérieurs dans l’hypermotilité gastri-que consécutive aux états d’hypoglycémie. C R Soc Biol (Paris) 104: 112–113

    Google Scholar 

  • Lalich J, Youmans WB, Meek WJ (1937) Insulin and gastric motility. Am J Physiol 120: 554–558

    CAS  Google Scholar 

  • Lee KY, Chey WY, Tai HH (1978) Roles of the vagus in endogenous release of secretin and exocrine pancreatic secretion in dog. In: Grossman M, Speranza V, Basso N, Lezoche E (eds) Gastrointestinal hormones and pathology of the digestive system. Plenum, New York, pp 211–216

    Google Scholar 

  • Lin TM (1980) Effects of insulin and glucagon on secretory and motor function of the gastrointestinal tract. In: Jerzy Glass GB (ed) Gastrointestinal hormones. Raven, New York, pp 639–691

    Google Scholar 

  • Lorber SH, Shay H (1962) Effect of insulin and glucose on gastric motor activity of dogs. Gastroenterology 43: 564–574

    CAS  Google Scholar 

  • Manville IA, Chuinard EG (1934) Studies on gastric hunger mechanisms. Am J Dig Dis 1: 688–693

    Google Scholar 

  • Marco J, Hedo JA, Villanueva ML (1978) Control of pancreatic polypeptide secretion by glucose in man. J Clin Endocrinol Metab 46: 140–145

    PubMed  CAS  Google Scholar 

  • Meythaler F, Graeser F (1935) Die Wirkung des Insulins auf den Darm. Arch Exp Pathol Pharmakol 178: 27–35

    CAS  Google Scholar 

  • Moniuszko-Jokaniuk J (1974) Influence of insulin on the effect of neostigmine in healthy mice and mice with alloxan-induced diabetes mellitus. Acta Physiol Pol 25: 497–508

    Google Scholar 

  • Mulinos MG (1933) The gastric hunger mechanism. IV. The influence of experimental alterations in blood sugar concentration on the gastric hunger contractions. Am J Physiol 104: 371–378

    CAS  Google Scholar 

  • Necheles H, Olson WH, Morris R (1941) Depression of gastric motility by insulin. Am J Dig Dis 8: 270–273

    CAS  Google Scholar 

  • Nga CS, Bogach PG, Groisman SD (1973) Mechanisms of the effect of insulin hypoglycemia on colon motility. Byull Eksp Biol Med 76: 12–15

    CAS  Google Scholar 

  • Paton WDM, Vizi ES (1969) The inhibitory action of noradrenalin and adrenalin on acetyl-choline output by guinea-pig ileum longitudinal muscle strip. Br J Pharmacol 35: 10–29

    PubMed  CAS  Google Scholar 

  • Pavel I, Milcou SM (1932) Action de l’insuline sur l’intestin. C R Soc Biol (Paris) 109: 776–779

    CAS  Google Scholar 

  • Postlethwaite RW, Hill HV, Chittum JR, Grimson KS (1948) Effect of vagotomy and of drugs on gastric motility. Ann Surg 128: 184–194

    Google Scholar 

  • Prasad S (1934) Effect of insulin on the contraction of the intestinal muscle. Indian J Med Res 21: 563–567

    CAS  Google Scholar 

  • Quigley JP (1928/1929) Action of insulin on the gastric motility of man. Proc Soc Exp Biol Med 26:769–770

    Google Scholar 

  • Quigley JP, Barnes BO (1930) Action of insulin on the motility of the gastrointestinal tract. VI. Antagonistic action of posterior pituitary lobe preparations. Am J Physiol 95: 7–12

    Google Scholar 

  • Quigley JP, Hallaran WR (1932) The independence of spontaneous gastrointestinal motility and blood sugar levels. Am J Physiol 100: 102–110

    CAS  Google Scholar 

  • Quigley JP, Solomon EI (1929/1930) Action of insulin on the motility of the gastrointestinal tract. V. a. Action on the human duodenum. b. Action on the colon of dogs. Am J Physiol 91: 488–495

    Google Scholar 

  • Quigley JP, Templeton RD (1929/1930) Action of insulin on the motility of the gastrointestinal tract. IV. Action on the stomach following double vagotomy. Am J Physiol 91: 482–487

    Google Scholar 

  • Quigley JP, Johnson V, Solomon EI (1929) Action of insulin on the motility of the gastrointestinal tract. Am J Physiol 90: 89–98

    Google Scholar 

  • Regan.JF (1933) The action of insulin on the motility of the empty stomach. Am J Physiol 104: 91–95

    Google Scholar 

  • Ruckebusch Y (1979) Interaction of duodenal and antral activity in sheep and dogs. J Physiol (Lond) 254: 79P-80 P

    Google Scholar 

  • Ruckebusch M, Fioramonti J (1975) Insuline-secretion et motricité intestinale. C R Soc Biol (Paris) 169: 435–439

    CAS  Google Scholar 

  • Schapiro H, Woodward ER (1959) The action of insulin hypoglycemia on the motility of the human gastrointestinal tract. Am J Dig Dis 4: 787–791

    PubMed  CAS  Google Scholar 

  • Schwartz TW (1978) Pancreatic polypeptide (PP). In: Grossman M, Speranza V, Basso N, Lezoche E (eds) Gastrointestinal hormones and pathology of the digestive system. Plenum, New York, pp 165–168

    Google Scholar 

  • Simici D, Giurea G, Dimitriu C (1927) L’action de l’insuline sur la motilité et l’évacuation de l’estomac â l’état normal et pathologique. Arch Mal Appar Dig Mal Nutr 17: 17–18

    Google Scholar 

  • Singh RV, Sud SC, Bahga HS, Soni BK (1972) Effect of insulin on rumen motility, blood glucose and blood lactic acid in male buffalo-calves (Bubalus bubalis). Indian J Anim Sci 42: 784–788

    CAS  Google Scholar 

  • Sive AA, Vinik AI, Hickman-Van Hoorn R, Van Tonder S (1978) Secretory response of pancreatic polipeptide in man and pigs. Scand J Gastroenterol [Suppl 49] 13: A169

    Google Scholar 

  • Templeton RD, Quigley JP (1929/1930) The action of insulin on the motility of the gastrointestinal tract. II. Action on the Heidenhain pouch. Am J Physiol 91: 467–474

    Google Scholar 

  • Unger RH, Eisentraut AM (1969) Entero-insular axis. Arch Intern Med 123: 261–266

    PubMed  CAS  Google Scholar 

  • Wilder RL, Schultz FW (1932) The action of atropine and adrenalin on gastric tonus and hypermotility induced by insulin hypoglycemia. Am J Physiol 96: 54–58

    Google Scholar 

  • Winter LB, Smith W (1924) On the effect of insulin on the isolated intestine of the rabbit. J Physiol (Lond) 58: 12

    Google Scholar 

  • Adrian TE, Greenberg GR, McCloy RF, Fitzpatrick ML, Bloom SR (1979) How to assess the physiological role of a new peptide hormone: pancreatic polypeptide infusion in man. J Endocrinol 81: 154P-155 P

    PubMed  CAS  Google Scholar 

  • Chance RE, Root MA, Galloway JA (1976) The immunogenicity of insulin preparations. Acta Endocrinol 83 (S-205): 185–196

    CAS  Google Scholar 

  • Duke GE, Kimmel JR (1978) Inhibition of gastric motility in turkey by avian pancreatic peptide (Abstr 849). Fed Proc 37: 373

    Google Scholar 

  • Floyd JC, Fajans SS, Pek S (1978) Physiologic regulation of plasma levels of PP in man. In: Bloom SR (ed) Gut hormones. Churchill Livingstone, Edinburgh London, pp 247–253

    Google Scholar 

  • Gustayson S, Johansson H, Lundquist G, Nilsson F (1977) Effects of vasoactive intestinal peptide and pancreatic polypeptide on small bowel propulsion in the rat. Scand J Gastroenterol 12: 993–997

    Google Scholar 

  • Kimmel JR, Pollock HG, Hazelwood RL (1968) Isolation and characterization of chicken insulin. Endocrinology 83: 1323–1330

    PubMed  CAS  Google Scholar 

  • Lin TM (1980) Pancreatic polypeptide: isolation, chemistry, and biological function. In: Jerzy Glass GB (ed) Gastrointestinal hormones. Raven, New York, pp 275–303

    Google Scholar 

  • Lin TM, Chance RE (1974a) Bovine pancreatic polypeptide (BPP) and avian pancreatic peptide ( APP); candidate hormones of the gut. Gastroenterology 67: 737–738

    Google Scholar 

  • Lin TM, Chance RE (1974b) Gastrointestinal actions of a new bovine pancreatic peptide (BPP). In: Chey WY, Brooks FP (eds) Endocrinology of the gut. Thorofare, NJ, pp 143–145

    Google Scholar 

  • Lin TM, Chance RE (1978) Spectrum of gastrointestinal actions of bovine PP. In: Bloom SR (ed) Gut hormones. Churchill Livingstone, Edinburgh London, pp 242–246

    Google Scholar 

  • Rattan S, Goyal RK (1979) Effect of bovine pancreatic polypeptide on the opossum lower esophageal sphincter. Gastroenterology 77: 672–676

    PubMed  CAS  Google Scholar 

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Authors
  1. G. Bertaccini
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Editors and Affiliations

  1. School of Medicine, University of Parma, I-43100, Parma, Italy

    Giulio Bertaccini M.D. (Head of the Department of Pharmacology) (Head of the Department of Pharmacology)

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© 1982 Springer-Verlag Berlin Heidelberg

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Bertaccini, G. (1982). Peptides: Pancreatic Hormones. In: Bertaccini, G. (eds) Mediators and Drugs in Gastrointestinal Motility II. Handbook of Experimental Pharmacology, vol 59 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68474-6_4

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  • DOI: https://doi.org/10.1007/978-3-642-68474-6_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-68476-0

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