One of the main themes to emerge from the group’s discussion of injury was that of specificity. The specificity of injury to the nervous system in multiple sclerosis has not yet been defined in terms of specific immune or viral-related damage to either oligodendrocyte or myelin. Given a large body of evidence suggesting that multiple sclerosis is an autoimmune disease, the antigen against which the autoimmune response is directed is yet to be defined. Similarly, viral induced injury must also be understood in terms of mechanisms by which specificity of injury occurs. In some toxin models, excellent example of specificity of injury exist. (A. Pappenheimer, this volume).
KeywordsMigration Arthritis Dopamine Influenza Pyridine
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