One of the main themes to emerge from the group’s discussion of injury was that of specificity. The specificity of injury to the nervous system in multiple sclerosis has not yet been defined in terms of specific immune or viral-related damage to either oligodendrocyte or myelin. Given a large body of evidence suggesting that multiple sclerosis is an autoimmune disease, the antigen against which the autoimmune response is directed is yet to be defined. Similarly, viral induced injury must also be understood in terms of mechanisms by which specificity of injury occurs. In some toxin models, excellent example of specificity of injury exist. (A. Pappenheimer, this volume).
KeywordsMultiple Sclerosis Sodium Channel Myelin Basic Protein Juvenile Rheumatoid Arthritis Diphtheria Toxin
Unable to display preview. Download preview PDF.
- (2).Coyle, P., and Wolinsky, J.S. Characterization of immune complexes in progressive rubella panencephalitis. Ann. Neurology, in press.Google Scholar
- (4).Helenius, A., and Simons, K. 1980. Mechanisms of animal virus entry into cells. In The Molecular Basis of Microbial Pathogenicity, eds. H. Smith, J.J. Skehel, and M.J. Turner, pp. 41–54. Dahlem Konferenzen. Weinheim: Verlag Chemie.Google Scholar