Abstract
It has been axiomatic for many years that large rings must be prepared under high dilution conditions so that the probability of the two ends meeting exceeds the probability of linear polymer formation7. It therefore seems remarkable that many of the syntheses of macrocyclic polyethers which have been reported involve less than dilute if not very concentrated conditions18. The success of these large-ring intramolecular SN2 reactions is generally attributed to the operation of a “template” effect during crown synthesis.
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Gokel, G.W., Korzeniowski, S.H. (1982). The Template Effect. In: Macrocyclic Polyether Syntheses. Reactivity and Structure Concepts in Organic Chemistry, vol 13. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68451-7_2
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DOI: https://doi.org/10.1007/978-3-642-68451-7_2
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