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Drug-Induced Chronic Hepatitis

  • Chapter
Immunological Aspects of Liver Disease

  • 33 Accesses

Abstract

Many drugs can produce hepatic damage, either as the result of a direct toxic effect on the liver which is dose-dependent or as an unpredictable effect which may or may not be a true drug hypersensitivity. When due to a direct hepatotoxin, hepatocellular necrosis varying in severity will be produced. All individuals are susceptible, the lesion is reproducible in animals and there is a direct dose relationship. Even after severe hepatic necrosis, should the patient survive, agents producing a direct hepatotoxic reaction seldom lead to a chronic lesion.

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Author information

Authors and Affiliations

  1. Professorial Medical Unit, Southampton General Hospital, Level F, Centre Block, Southampton, S09 4XY, England

    Ralph Wright

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  1. Ralph Wright
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Editor information

Editors and Affiliations

  1. Academic Department of Medicine, The Royal Free Hospital and Medical School, Pond Street, Hampstead, London, NW3 2QG, Great Britain

    Howard C. Thomas

  2. Division d’Hématologie du Department de Médicine Hôpital Cantonal, 25, rue Micheli-du Crest, CH-1211, Genève, Switzerland

    Peter A. Miescher

  3. Department of Molecular Immunology, Scripps Clinic and Research Foundation, La Jolla, CA, 92037, USA

    Hans J. Mueller-Eberhard

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© 1982 Springer-Verlag Berlin Heidelberg

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Wright, R. (1982). Drug-Induced Chronic Hepatitis. In: Thomas, H.C., Miescher, P.A., Mueller-Eberhard, H.J. (eds) Immunological Aspects of Liver Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68446-3_5

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  • DOI: https://doi.org/10.1007/978-3-642-68446-3_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-11310-2

  • Online ISBN: 978-3-642-68446-3

  • eBook Packages: Springer Book Archive

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