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Primary Liver Cancer and Its Relationship to Chronic Infection with the Hepatitis B Virus

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Immunological Aspects of Liver Disease

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Abstract

Evidence from numerous studies published since 1970 [12, 33, 36, 43] indicates a clear-cut association between primary liver cancer (PLC) and chronic infection with the hepatitis B virus (HBV). This association is currently believed to represent a causal relationship and is specifically restricted to hepatocellular or liver-cell carcinoma (HCC), which accounts for more than 80% of all primary liver tumors [9]. Cholangiocarcinoma or bile-duct carcinoma, the second malignant tumor grouped under the broader term of PLC, is not associated with chronic HBV infection and will not, therefore, be considered in this article. It must, however, be noted that in many studies, particularly of epidemiologic character, no distinction between HCC and cholangiocarcinoma is made and the non-discriminating term of PLC is used. Even so, data from such studies have not concealed the fact that the association with HBV specifically concerns hepatocellular cancer and not all PLCs [49].

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References

  1. Aden DP, Fogel A, Plotkin S, Damjanov I, Knowles BB (1979) Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line. Nature 282: 615

    Article  PubMed  CAS  Google Scholar 

  2. Allen DW, Cole P (1972) Viruses and human cancer. N Engl J Med 286: 70

    Article  PubMed  CAS  Google Scholar 

  3. Anthony PP, Vogel CL, Barker LF (1973) Liver cell dysplasia: a premalignant condition. J Clin Pathol 26: 217

    Article  PubMed  CAS  Google Scholar 

  4. Bagshawe AF, Gasengi DM, Cameron CH, Dorman J, Dane DS (1976) Hepatitis Bs antigen and liver cancer. A population-based study in Kenya. Br J Cancer 31: 581

    Google Scholar 

  5. Dudley FJ, Scheuer PJ, Sherlock S (1973) Natural history of hepatitis-associated antigen-positive chronic liver disease. Lancet II: 1388

    Google Scholar 

  6. Chakraborty PR, Ruiz-Opazo N, Shouval D, Shafritz DA (to be published) Identification of integrated hepatitis B virus DNA and expression of viral RNA in a human hepatocellular carcinoma cell line which produces hepatitis B surface antigen. Nature

    Google Scholar 

  7. Farber E (1976) On the pathogenesis of experimental hepatocellular carcinoma. In: Okuda K, Peters RL (eds) Hepatocellular carcinoma. J. Wiley, New York, p 3

    Google Scholar 

  8. Farber E (1978) Experimental liver carcinogenesis: a perspective. In: Remmer H, Bolt HM, Bannasch P, Popper H (eds) Primary liver tumors. MTP Press, Lancaster, p 357

    Google Scholar 

  9. Hadziyannis S (1980) Hepatocellular carcinoma and type B hepatitis. Clin Gastroenterol 9: 117

    PubMed  CAS  Google Scholar 

  10. Hadziyannis S (to be published) The “ground-glass” hepatocyte: An aid to diagnosis — a challenge to pathophysiology. In: Berk PD (ed) Frontiers in liver disease. Thieme-Stratton, New York

    Google Scholar 

  11. Hadziyannis S, Trichopoulos D (1978) Hepatocellular carcinoma in Greece and its relationship to the hepatitis B virus. In: Remmer H, Bolt HM, Bannasch P, Popper H (eds) Primary liver tumors. MTP Press, Lancaster, p 431

    Google Scholar 

  12. Hadziyannis S, Merikas GE, Afroudakis AP (1970) Hepatitis-associated antigen in chronic liver disease. Lancet II: 100

    Google Scholar 

  13. Hadziyannis S, Gerber MA, Vissoulis C, Popper H (1973) Cytoplasmic hepatitis B antigen in “ground-glass” hepatocytes of carriers. Arch Pathol 96: 327

    PubMed  CAS  Google Scholar 

  14. Hadziyannis S, Giustozi A, Moussouros A, Merikas G (1976) Hepatitis B core and surface antigens in the liver in primary liver cell carcinoma. In: Leevy CM (ed) Diseases of the liver and biliary tract, S. Karger, Basel, p 174

    Google Scholar 

  15. Hadziyannis S, Karvoutzis G, Manessis E, Dorn J, Merikas G (1979) Surveillance of patients with chronic liver disease by serial testing for serum a!-fetoprotein. In: Lehman FG (ed) Carcinoembryonic proteins. Vol. II. Elsevier Biomedical Press, Holland, p 403

    Google Scholar 

  16. Hoofnagle JH, Seeff LB, Bales ZB, Zimmerman HJ, VA Hepatitis Cooperative Study Group (1978) Type B hepatitis after transfusion with blood containing antibody to hepatitis B core antigen. N Engl J Med 298: 1379

    Google Scholar 

  17. Kew MC (1978) Hepatocellular cancer in Southern Africa. In: Remmer H, Bolt HM, Bannasch P, Popper H (eds) Primary liver tumors. MTP Press, Lancaster, p 170

    Google Scholar 

  18. Kew MC, Geddes EN, Macnab GM, Bersohn I (1974) Hepatitis-B antigen and cirrhosis in Bantu patients with primary liver cancer. Cancer 34: 539

    Article  Google Scholar 

  19. Kojima M, Udo K, Takahashi Y, Yashizawa H, Tsuda F, Itoh Y, Miyakawa Y, Mayumi M (1977) Correlation between titer of antibody to hepatitis B core antigen and presence of viral antigens in the liver. Gastroenterology 73: 664

    PubMed  CAS  Google Scholar 

  20. Kubo Y, Okuda K, Hashimoto M, Nagasaki Y, Ebata H, Nakajima Y, Musha H, Sakuma K, Ohtake H (1977) Antibody to hepatitis B core antigen in patients with hepatocellular carcinoma. Gastroenterology 72: 1217

    PubMed  CAS  Google Scholar 

  21. Kubo U, Okuda K, Musha H, Nakashima T (1978) Detection of hepatocellular carcinoma during a clinical follow-up of chronic liver disease. Gastroenterology 74: 578

    PubMed  CAS  Google Scholar 

  22. Lapis K, Beard D, Beard JW (1975) Transplantation of hepatomas induced in the avian liver by MC29 leukosis virus. Cancer Res 35: 132

    PubMed  CAS  Google Scholar 

  23. Lehman FG (1975) Early detection of hepatoma: prospective study in liver cirrhosis using passive hemagglutination and the radioimmunoassay. Ann NY Acad Sci 259: 196

    Article  Google Scholar 

  24. Macnab GM, Alexander JJ, Lecatsas G, Bey EM, Urbanowicz JM (1976) Hepatitis B surface antigen produced by a human hepatoma cell line. Br J Cancer 34: 509

    Article  PubMed  CAS  Google Scholar 

  25. Manessis E, Hadziyannis S, Karvoutzis G, Merikas G (1976) Epidemiological observations on primary liver cancer in Greece. Proceedings of the Fourth Panhellenic Congress of Gastroenterology. P Paschalides, Athens p 859

    Google Scholar 

  26. Manessis E, Hadziyannis S, Karvoutzis G, Moussouros A, Merikas G (1977) HBsAg positive and HBsAg negative hepatocellular carcinoma in Greece. Arc. Hellenic Med. Soc. Supplement Vol. 3: 4

    Google Scholar 

  27. Nazarewicz T, Krawczynski K, Slusarczyk J, Nowoslawski A (1977) Cellular localization of hepatits B virus antigen in patients with hepatocellular carcinoma coexisting with liver cirrhosis. J Infect Dis 135: 298

    Article  PubMed  CAS  Google Scholar 

  28. Okuda K (1976) Clinical aspects of hepatocellular carcinoma. Analysis of 134 cases. In: Okuda K, Peters RL (eds) Hepatocellular carcinoma. J. Wiley, New York, p 387

    Google Scholar 

  29. Okuda K, Kotoda K, Obota H, Hayashi N, Hisamitsu T, Tamiya M, Kubo Y, Yakushiji F, Nagata E, Jinnouchi S, Shimokawa Y (1975) Clinical observations during a relatively early stage of hepatocellular carcinoma, with special reference to serum a!-fetoprotein levels. Gastroenterology 69: 226

    PubMed  CAS  Google Scholar 

  30. Peters RL, Afroudakis AP, Tatter D (1977) The changing incidence of association of hepatitis B with hepatocellular carcinoma in California. Am J Clin Pathol 68: 1

    PubMed  CAS  Google Scholar 

  31. Popper H (1978) The increasing importance of liver tumors. In: Remer H, Bolt HM, Bannasch P, Popper H (eds) Primary liver tumors, MTP Press, Lancaster, p 3

    Google Scholar 

  32. Primack A, Vogel CL, Barker LF (1973) Immunologic studies in Uganda patients with hepatocellular carcinoma. Br Med J 1: 16

    Article  PubMed  CAS  Google Scholar 

  33. Prince AM (1971) Role of serum hepatitis virus in chronic liver disease. Gastroenterology 60: 913

    PubMed  CAS  Google Scholar 

  34. Prince AM, Szmuness W, Michon J, Diebolt G, Linhard J, Quenum C, Sankale M (1975) A case/control study of the association between primary liver cancer and hepatitis B infection in Senegal. Int J Cancer 16: 376

    Article  PubMed  CAS  Google Scholar 

  35. Reed WD, Eddleston ALWF, Stern RB, Williams R, Zuckerman AJ, Bowes A, Earl PM (1973) Detection of hepatitis B antigen by radioimmunoassay in chronic liver disease and hepatocellular carcinoma in Great Britain. Lancet II: 690

    Google Scholar 

  36. Sherlock S, Fox RA, Niazi SP, Sheuer PJ (1970) Chronic liver disease and primary liver-cell cancer with hepatitis-associated ( Australia) antigen in serum. Lancet I: 1243

    Google Scholar 

  37. Shikata T (1976) Primary liver carcinoma and liver cirrhosis. In: Okuda K, Peters RL (eds) Hepatocellular carcinoma, J. Wiley, New York, p 53

    Google Scholar 

  38. Skelly J, Copeland J A, Howard CR, Juckerman AJ (1979) Hepatitis B surface antigen produced by a human hepatoma cell line. Nature 282: 617

    Article  PubMed  CAS  Google Scholar 

  39. Skinhoj P, Hansesn JPH, Nielsen MH, Mikkelsen F (1978) Occurrence of cirrhosis and primary liver cancer in an Eskimo population hyperendemically infected with hepatitis B virus. Am J Epidemiol 108: 121

    PubMed  CAS  Google Scholar 

  40. Summers J, O’Connell A, Maupas P, Coudeau A, Coursaget P, Drucker J (1978) Hepatitis B virus DNA in primary hepatocellular carcinoma tissue. J Med Virol 2: 207

    Article  PubMed  CAS  Google Scholar 

  41. Summers J, Smolec JM, Snyder RA (1978) A virus similar to human hepatitis B virus associated with hepatitis and hepatoma in woodchucks. Proc Natl Acad Sci USA 75: 4533

    Article  PubMed  CAS  Google Scholar 

  42. Sutnick AI, Millman L, London WT, Blumberg BS (1972) The role of Australia antigen in viral hepatitis and other diseases. Annu Rev Med 23: 161

    Article  PubMed  CAS  Google Scholar 

  43. Szmuness W (1978) Hepatocellular carcinoma and the hepatitis B virus: evidence for a causal association. Prog Med Virol 24: 40

    PubMed  CAS  Google Scholar 

  44. Szmuness W, Stevens CE, Ikram H, Much MI, Harley EJ, Hollinger B (1978) Prevalence of hepatitis B virus infection and hepatocellular carcinoma in Chinese-Americans. J Infect Dis 137: 822

    Article  PubMed  CAS  Google Scholar 

  45. Tabor E, Gerety RJ, Vogel CL, Boyley AC, Anthony PP, Chan CH, Barker LF (1977) Hepatitis B virus infection and primary hepatocellular carcinoma. J Natl Cancer Inst 58: 1197

    Google Scholar 

  46. Thung SM, Gerber MA, Sarno E, Popper H (1979) Distribution of five antigens in hepatocellular carcinoma. Lab Invest 41: 101

    PubMed  CAS  Google Scholar 

  47. Trichopoulos D, Papaevangelou G, Violaki M, Vissoulis Ch, Sparros L, Manousos O (1976) Geographical correlation between mortality from primary hepatic carcinoma and prevalence of hepatitis B surface antigen in Greece. Br J Cancer 34: 83

    Article  PubMed  CAS  Google Scholar 

  48. Trichopoulos D, Tabor E, Gerety RJ, Xirouchaki E, Sparros L, Munoz N, Linsell CA (1978) Hepatitis B and primary hepatocellular carcinoma in European populations. Lancet II: 1217

    Google Scholar 

  49. Trichopoulos D (to be published) The causes of primary hepatocellular carcinoma in man. Prog Med Virol

    Google Scholar 

  50. Vogel L, Anthony PP, Mody N, Barker LF (1970) Hepatitis-associated antigen in Ugandan patients with hepatocellular carcinoma. Lancet II: 621

    Google Scholar 

  51. WHO, IARC (1976) Cancer incidence in five continents. Vol. Ill, Waterhouse J, Muir C, Correa P, Powell J (eds) IARC Scientific Publications, Lyon

    Google Scholar 

  52. Zuckerman A (1980) Prophylaxis of hepatitis type B: Immunoglobulins and vaccines. Clin Gastroenterol 9: 65

    PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Second Department of Medicine, University of Athens Medical School, Greece

    Stephanos J. Hadziyannis

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  1. Stephanos J. Hadziyannis
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Editors and Affiliations

  1. Academic Department of Medicine, The Royal Free Hospital and Medical School, Pond Street, Hampstead, London, NW3 2QG, Great Britain

    Howard C. Thomas

  2. Division d’Hématologie du Department de Médicine Hôpital Cantonal, 25, rue Micheli-du Crest, CH-1211, Genève, Switzerland

    Peter A. Miescher

  3. Department of Molecular Immunology, Scripps Clinic and Research Foundation, La Jolla, CA, 92037, USA

    Hans J. Mueller-Eberhard

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© 1982 Springer-Verlag Berlin Heidelberg

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Hadziyannis, S.J. (1982). Primary Liver Cancer and Its Relationship to Chronic Infection with the Hepatitis B Virus. In: Thomas, H.C., Miescher, P.A., Mueller-Eberhard, H.J. (eds) Immunological Aspects of Liver Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68446-3_14

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  • DOI: https://doi.org/10.1007/978-3-642-68446-3_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-11310-2

  • Online ISBN: 978-3-642-68446-3

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