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Ionic Basis of Smooth Muscle Action Potentials

  • Chapter
Mediators and Drugs in Gastrointestinal Motility I

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 59 / 1))

Abstract

The action potentials of smooth muscles are important in triggering and synchronizing contraction. However, the contribution of action potentials to these functions varies greatly, depending on the type of smooth muscle. Although a typical action potential having an all-or-nothing property can be observed in the smooth muscle of some organs, such as gastrointestinal (GI) tract, vas deferens, or uterus, it is more common that the amplitude and the shape of action potentials vary from time to time even in the same tissue, and also from one tissue to another. Most trachéal smooth muscles and some vascular smooth muscles are inexcitable under normal conditions. There is a spectrum of smooth muscles between the highly excitable type and the inexcitable type (Creed 1979). Thus, in most smooth muscles, the action potential is graded, and does not obey the all-or-nothing law. Owing to this variability, a general description of the action potential is difficult.

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  1. T. Tomita
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  1. School of Medicine, University of Parma, Parma, I-43100, Italy

    Giulio Bertaccini M.D. (Head of the Department of Pharmacology) (Head of the Department of Pharmacology)

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Tomita, T. (1982). Ionic Basis of Smooth Muscle Action Potentials. In: Bertaccini, G. (eds) Mediators and Drugs in Gastrointestinal Motility I. Handbook of Experimental Pharmacology, vol 59 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68437-1_4

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