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Experimentelle Methoden

  • Chapter
Dünndarm A

Part of the book series: Handbuch der inneren Medizin ((INNEREN 3,volume 3 / 3 / A))

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Zusammenfassung

Nach frühen Experimenten im 16. und 17. Jahrhundert begannen quantitative Versuche zur intestinalen Resorption am Menschen Ende des 18. Jahrhunderts (Spallanzani 1780). Von der ersten Hälfte des 19. Jahrhunderts sind Experimente zur Aufklärung der intestinalen Resorption an Tieren bekannt, wobei schon In-situ-Präparationen angewandt wurden (s. Literaturangaben bei Parsons 1968). Im allgemeinen beschränkten sich In-vivo-Versuche in Tieren auf die orale Applikation von Stoffen und die Erfassung derselben oder ihrer Digestionsprodukte im Gastrointestinaltrakt der getöteten Tiere. Durch Cori (1925) wurde diese Methode verbessert, indem er in Versuchen zur Kohlenhydratresorption verschiedene Zucker mit Hilfe einer Magensonde verabreichte. Beeinflussungen durch die Magenentleerung wurden später durch die Plazierung einer Duodenalsonde umgangen (Fenton 1945). Die heute weit verbreiteten und vielfach modifizierten Perfusionsmethoden an Tieren wurden durch Versuche von Sols u. Ponz (1947) begründet. Ebenso wie beim Tier wurde auch beim Menschen die quantitative Erfassung intestinaler Resorptionsleistungen durch die Einführung von Sonden zugänglich. Nach Versuchen von Abbott u. Miller (1936) wurden erstmals von Nicholson u. Chornock (1942) direkte Messungen zur Dünndarmresorption am Menschen durchgeführt.

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Authors
  1. B. Elsenhans
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Editor information

Editors and Affiliations

  1. Cattedra di Clinica Medica III, Università di Bologna, Via Massarenti, 9, I-Bologna, Italia

    F. Bazzoli

  2. I. Medizinische Abteilung, Marienkrankenhaus, Alfredstr. 9, D-2000, Hamburg 76, Deutschland

    R. Böhmer

  3. Medizinische Klinik II, Stadtkrankenhaus, Leimenstr. 20, D-6450, Hanau 1, Deutschland

    W. F. Caspary

  4. Abteilung Interne Strahlendiagnostik, Mannkopffstr. 1, D-3550, Marburg, Deutschland

    H. Dombrowski

  5. I. Medizinische Klinik und Poliklinik, Klinikum der Johannes Gutenberg-Universität, Lagenbeckstr. 1, D-6500, Mainz, Deutschland

    B. Eckhardt  & B. Lembcke  & 

  6. Medizinische Klinik und Poliklinik, Abteilung für Gastroenterologie und Stoffwechselkrankheiten, Kliniken der Universität, Humboldtallee 1, D-3400, Göttingen, Deutschland

    B. Elsenhans

  7. Abteilung für Allgemein- und Abdominalchirurgie, Klinikum der Johann-Wolfgang-Goethe-Universität, Theodor-Stern-Kai 7, D-6000, Frankfurt 70, Deutschland

    A. Encke

  8. Gastrointestinal Unit, Western General Hospital, University of Edinburgh, Crewe Road, EH4 2XU, Edinburgh, Scotland, UK

    A. Ferguson

  9. Institut für Pharmakologie und Toxikologie, Medizinische Fakultät der Ludwig-Maximilians-Universität, Nußbaumstr. 26, D-8000, München 2, Deutschland

    W. Forth

  10. School of Medicine, Department of Medicine, Montefiore Hospital, University of Pittsburgh, 3459 Fifth Avenue, Pittsburgh, PA, 15213, USA

    H. Fromm

  11. I. Universitätsklinik für Gastroenterologie und Hepatologie, Lazarettgasse 14, A-1090, Wien, Österreich

    A. Gangl

  12. Medizinische Klinik und Poliklinik, Abteilung für Innere Medizin mit Schwerpunkt Gastroenterologie, Universitätsklinikum Steglitz, Hindenburgdamm 30, D-1000, Berlin 45, Deutschland

    S. Gutschmidt

  13. School of Medicine, Department of Anatomy, Case Western Reserve University, Cleveland, OH, 44106, USA

    U. Hopfer

  14. Health Science Center at Dallas, Southwestern Medical School, Department of Internal Medicine, The University of Texas, 5323 Harry Hines Boulevard, Dallas, TX, 75235, USA

    G. J. Kreijs  & R. Wanitschke  & 

  15. Abteilung Gastroenterologie und Stoffwechsel, Zentrum Innere Medizin der Universität, Robert-Koch-Str. 40, Göttingen, D-3400, Deutschland

    K.-H. Meyer zum Büschenfelde

  16. Institut für Klinische und Experimentelle, Nuklearmedizin der Universitätskliniken, Joseph-Stelzmann-Str. 9, Köln 41, D-5000, Deutschland

    G. Mödder

  17. Theoretische Medizin, Fachrichtung 3.4 - Pharmakologie-Toxikologie, Fachbereich 3 der Universität des Saarlandes, Homburg, D-6650, Deutschland

    G. Nell

  18. Pathologisches Institut, Universitäts-Krankenhaus Eppendorf, Martinistr. 52, Hamburg 20, D-2000, Deutschland

    H. F. Otto

  19. 2. Medizinische Klinik und Poliklinik, Medizinische Einrichtungen der Universität, Moorenstr. 5, Düsseldorf 1, D-4000, Deutschland

    H. Peerenboom

  20. Institut für Ernährungswissenschaft der Justus-Liebig-Universität, Wilhelmstr. 20, Giessen, D-6300, Deutschland

    G. Rehner

  21. Innere Abteilung, Kreiskrankenhaus, Bunsenstr. 120, Böblingen, D-7030, Deutschland

    G. Rettenmaier

  22. Service de Chirurgie, Département de Chirurgie Expérimentale, Hôpital Cantonal Universitaire, Lausanne 11 CHUV, CH-1011, Schweiz

    J. W. L. Robinson

  23. Abteilung Klinische Chemie, Zentrallabor, Klinikum der Universität, Uferstr. 2a, Marburg, D-3550, Deutschland

    K. Rommel

  24. Medizinische Klinik mit Poliklinik der Universität, Krankenhausstr. 12, Erlangen, D-8520, Deutschland

    H. Ruppin

  25. Experimentelle Chirurgie der Allgemeinchirurgie der Universität, Hospitalstr. 40, Kiel 1, D-2300, Deutschland

    J. Seifert

  26. Froedtert Memorial Lutheran Hospital, Section of Gastroenterology, The Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI, 53226, USA

    K. H. Soergel

  27. Gastrointestinal Unit and Department of Medicine, Wolson Gastrointestinal Laboratories, Western General Hospital, University of Edinburgh, Crewe Road, Edinburgh, EH4 2XU, Scotland, UK

    S. Strobel

  28. Zentrum der Kinderheilkunde, Abteilung Allgemeine Pädiatrie I, Sektion Kindergastroenterologie, Klinikum der Johann-Wolfgang-Goethe-Universität, Theodor-Stern-Kai 7, Frankfurt 70, D-6000, Deutschland

    S. Strobel

  29. Fachbereich Medizin, Anatomisches Institut, Johannes Gutenberg-Universität, Saarstr. 19/21, Mainz, D-6500, Deutschland

    L. Vollrath

  30. II. Medizinische Klinik, Krankenhausstiftung Bamberg, Untere Sandstr. 32, Bamberg, D-8600, Deutschland

    H. J. Weis

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Elsenhans, B. (1983). Experimentelle Methoden. In: Bazzoli, F., et al. Dünndarm A. Handbuch der inneren Medizin, vol 3 / 3 / A. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68415-9_4

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  • DOI: https://doi.org/10.1007/978-3-642-68415-9_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-68416-6

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