Zusammenfassung
Die Entdeckung „kleiner Lebewesen“auf seinen Zähnen und im Stuhl durch van Leeuwenhoeck im Jahre 1719, gleichsam der Beginn der Darmbakteriologie, läßt bereits topographische Interessenschwerpunkte der gastrointestinalen Mikrobiologie in den nachfolgenden 250 Jahren erkennen. Während die Flora des Oropharynx und der Fäzes extensiv untersucht worden ist, war die mikrobielle Ökologie des Dünndarms lange Gegenstand kontroverser und vielfach spekulativer Auffassungen. Teilweise liegen die Ursachen hierfür in der relativen Unzugängigkeit dieses Darmabschnitts und seiner geringen Keimdichte, die zudem durch die routinemäßig vorhandenen bakteriologischen Techniken nur unzureichend erfaßt wird (Borriello et al. 1978). Die Diskrepanz zwischen der Zahl mikroskopisch sichtbarer Keime im Dünndarm und den häufig negativen Kulturergebnissen, ein bereits frühzeitig erkanntes Stigma der Mikrobiologie des Gastrointestinaltrakts (Cohnheim 1908), ist bis heute nicht beseitigt. Während die bakteriologischen Voraussetzungen der Kultur, Identifikation und Enumeration der meisten im Gastrointestinaltrakt vorkommenden Genera als etablierte Verfahren gelten können, ist die Taxonomie, Isolation, Identifikation und Zählung von einzelnen Spezies der obligat anaeroben Gattungen uneinheitlich und durch methodische Schwierigkeiten gekennzeichnet (Borriello et al. 1978).
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Lembcke, B. (1983). Bakterienflora des Dünndarms. In: Bazzoli, F., et al. Dünndarm A. Handbuch der inneren Medizin, vol 3 / 3 / A. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68415-9_21
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