Zusammenfassung
Bis vor wenigen Jahren galt der Dünndarm fast ausschließlich als Resorptionsorgan. Erst der tierexperimentellen und klinischen Forschung der beiden letzten Jahrzehnte verdanken wir die Kenntnis eines wesentlich breiteren Funktionsspektrums dieses Organs. So spielt der Dünndarm abgesehen von seiner digestive-resorptiven Funktion auch eine wichtige Rolle in verschiedenen Aspekten der Immunologie: sein lymphatisches Gewebe (gut associated lymphoid tissue, Galt) stellt eine erste Barriere gegen das Eindringen von bakteriellen und Nahrungsmittelantigenen aus dem Darmlumen dar (Hall 1979), beeinflußt daher maßgeblich die Immunitätslage des Organismus (s. auch S. 73, 702) und es besteht heute kein Zweifel mehr an der Schlüsselstellung des Immunsystems des Darmes in der Pathogenese zahlreicher gastrointestinaler Erkrankungen (McGuigan 1973).
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Gangl, A. (1983). Dünndarm und Lipoproteinstoffwechsel. In: Bazzoli, F., et al. Dünndarm A. Handbuch der inneren Medizin, vol 3 / 3 / A. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68415-9_18
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