The Role of Cyclic Nucleotides in the Control of Anterior Pituitary Gland Activity

  • F. Labrie
  • P. Borgeat
  • J. Drouin
  • L. Lagace
  • V. Giguere
  • V. Raymond
  • M. Godbout
  • J. Massicotte
  • L. Ferland
  • N. Barden
  • M. Beaulieu
  • J. Cote
  • J. Lepine
  • H. Meunier
  • R. Veilleux
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 58 / 2)

Overview

The anterior pituitary gland secretes six known polypeptide hormones: ACTH (adrenocorticotropin), GH (growth hormone), PRL (prolactin), TSH (thyrotropin), LH (luteinizing hormone), and FSH (follicle-stimulating hormone). The rate of secretion of these individual polypeptides is specifically controlled by neurohormones released from the hypothalamus and transported to their adenohypophyseal site of action by a short portal blood system (Schally et al. 1968). The secretion of LH, FSH, and ACTH is known to be under only positive hypothalamic control, whereas that of GH, TSH, and PRL results from the balance of action of inhibitory and stimulatory neurohormones (Fig. 1). The overall influence of the hypothalamus on GH and TSH secretion is stimulatory, whereas it is inhibitory on PRL secretion.

Keywords

Morphine Norepinephrine Progesterone PGE2 Tritium 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1982

Authors and Affiliations

  • F. Labrie
  • P. Borgeat
  • J. Drouin
  • L. Lagace
  • V. Giguere
  • V. Raymond
  • M. Godbout
  • J. Massicotte
  • L. Ferland
  • N. Barden
  • M. Beaulieu
  • J. Cote
  • J. Lepine
  • H. Meunier
  • R. Veilleux

There are no affiliations available

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