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Cyclic Nucleotides pp 465–524Cite as

The Role of Cyclic Nucleotide Metabolism in the Eye

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 58 / 2))

Overview

This chapter summarizes cyclic nucleotide involvement in the eye. While all areas of the eye are discussed, greatest emphasis will be on the retina. The levels of retinal cyclic nucleotides vary according to several factors, including age, type of predominant photoreceptor, conditions of light- or dark-adaptation, states of pathology, etc. The cyclic GMP system is most important in rod visual cells; its principal effector is light, but it responds also to ischemic conditions, free radicals, depolarizing agents, cations and fatty acids. Cyclic AMP metabolism is minimal in rod photoreceptors. In contrast, in cone visual cells, the cyclic AMP system predominates and is responsive to light, with minimal levels of cyclic GMP present.

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  1. D. B. Farber
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  1. Biochemical Neuropharmacology Unit, National Institutes of Health, Room 5c 108/Bldg. 10, Bethesda, MD, 20205, USA

    John W. Kebabian

  2. Neuropharmacology Research Laboratory, Departments of Neurology and Pharmacology, Harvard Medical School, Massachusetts General Hospital, Fruit Street, Boston, MA, 02114, USA

    James A. Nathanson

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Farber, D.B. (1982). The Role of Cyclic Nucleotide Metabolism in the Eye. In: Kebabian, J.W., Nathanson, J.A. (eds) Cyclic Nucleotides. Handbook of Experimental Pharmacology, vol 58 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68393-0_11

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