Abstract
As pointed out by Morse in the preceding paper, there are good reasons to focus particular attention on X-MuLV with regard to the spontaneous or inducible expression of endogenous viral genes in mouse tissues. Our report emphasizes the expression of endogenous viral genes of xenotropic origin in association with immunological phenomena.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Chattopadhyay SK, Lander MR, Rands E, Lowy DR (1980) Structure of endogenous murine leukemia virus DNA in mouse genomes. Proc Natl Acad Sci USA 77:5774–5778
Elder JH, Jensen FC, Bryant MC, Lerner RA (1977) Polymorphism of the major envelope glyco-protein (gp 70) of murine C-type viruses: virion associated differentiation antigens encoded by a multi-gene family. Nature 267:23–28
England JM, Halpern MS (1979) Endogenous oncoronaviral antigen in the burse of Fabricius of 15 B x 72 chickens. Proc Natl Acad Sci USA 76:2908–2911
Gillis S, Smith KA (1977) Long-term culture of tumour-specific cytotoxic T cells. Nature 268:154–155
Greenberger JS, Phillips MS, Stephenson JR, Aaronson SA (1975) Induction of type C-RNA virus by lipopolysaccharide. J Immunol 115:317–320
Gronowicz E, Coutinho A, Melchers F (1976) A plaque assay for all cells secreting Ig of a given type or class. Eur J Immunol 6:588–590
Hirsch MS, Phillips SM, Szolnik C, Black PH, Schwartz RS, Carpenter CB (1972) Activation of leukemia viruses by graft-versus-host and mixed lymphocyte reactions in vitro. Proc Natl Acad Sci USA 69:1069–1072
Jongstra J, Moroni C (1981) Lipopolysaccharide induces retroviral antigen expression in 129/J mouse lymphocytes: evidence for assembly of defective viral particles. J Virol 37:1044–1050
Kienner D, Horak I, Schimpl A, Wecker E (1981) Expression of endogenous retroviral gp70 by antigen activated cytotoxic and suppressor T lymphocytes of mice. Proc Natl Acad Sci USA (in press)
Kozak CA, Rowe WP (1979) Genetic mapping of the ecotropic murine leukemia virus-inducing locus of BALB/c mouse to chromosome 5. Science 204:69–71
Moroni C, Schumann G (1975) Expression of endogenous C-type viral antigen on normal mouse haematopoetic stern cells. Nature 254:60–61
Moroni C, Schumann G (1977) Are endogenous C-type viruses involved in the immune system. Nature 269:600–601
Moroni C, Schumann G (1978) Mitogen induction of murine C-type viruses. IV. Effects of lipo-protein E. coli, Pokeweed mitogen, and dextron sulphate. J Gen Virol 83:497–503
Morse HC, Chused TM, Hartley JW, Mathieson BJ, Sharrow SO, Taylor BA (1979a) Expression of xenotropic murine leukemia viruses as cell-surface gp70 in genetic crosses between strains DBA/2 and C57 B1/6. J Exp Med 149:183–1196
Morse HC, Chused TM, Boehm-Truitt M, Mathieson BJ, Saarrow SO, Hartley JW, Xen CSA (1979b) Cell surface antigens related to the major glycoproteins (gp70) of xenotropic murine leukemia viruses. J Immunol 122:443–454
Muramatsu T, Koide N, Ceccarini C, Atkinson PH (1976) Characterization of manose-labeled gly-copeptides from human diploid cells and their growth-dependent alterations. J Biol Chem 251:4673–4679
Obata Y, Stockert E, O’Donnell PV, Okubo S, Snyder HW, Old LJ (1978) G(RADA 1): a new cell surface antigen of mouse leukemia defined by naturally occurring antibody (and its relationship to murine leukemia virus. J Exp Med 147:1089–1105
Old LJ, Boyse EA, Stockert E (1965) The G (gross) leukemia antigen. Cancer Res 25:813–818
Pickel K, Hoffmann MK (1977) The Ly phenotype of suppressor T cells arising in mice subjected to a graft-versus-host reaction. J Exp Med 145:1169–1175
Schumann G, Moroni C (1976) Mitogen induction of murine C-type viruses. I. Analysis of lym-phoid cell subpopulations. J Immunol 116:1145–1150
Schumann G, Moroni C (1977) Mitogen induction of murine C-type viruses. III. Effect of culture conditions, age and genotype. Virology 79:81–87
Stockert EL, Old LJ, Boyse EA (1971) The Gis system. A cell surface allo-antigen associated with murine leukemia virus; implications regarding chromosomal integration of the viral genome. J Exp Med 133:1334–1355
Wecker F (1977) Expression of endogenous viral antigens during immune response. Med Micro-biol Immunol (Berl) 164:231–238
Wecker E, Schimpl A, Hünig T (1977) Expression of MuLV gp 71-like antigen in normal mouse spleen cells induced by antigenic stimulation. Nature 269:598–600
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Wecker, E., Horak, I. (1982). Expression of Endogenous Viral Genes in Mouse Lymphocytes. In: Wecker, E., Horak, I. (eds) Retrovirus Genes in Lymphocyte Function and Growth. Current Topics in Microbiology and Immunology, vol 98. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68369-5_4
Download citation
DOI: https://doi.org/10.1007/978-3-642-68369-5_4
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-68371-8
Online ISBN: 978-3-642-68369-5
eBook Packages: Springer Book Archive