Expression of Xenotropic Murine Leukemia Viruses

  • Herbert C. MorseIII
  • Janet W. Hartley
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 98)

Abstract

The possibility that env gene products of endogenous murine leukemia viruses might function as determinants of normal cellular differentiation or in cell-cell communication has been suggested by several lines of investigation. First, the GIXgp70 molecule of strain 129 mice was found to behave as a differentiation alloantigen of T cells in that it was expressed in high levels on thymocytes but not on peripheral T cells (Stockert et al. 1971). Second, it was observed that while gp70 antigens could be found in many body tissues, particularly high levels were detected in certain anatomic sites such as the seminal vesicles and gall bladder epithelium (Lerner et al. 1976). Third, expression of gp70 on the surface of lymphocytes was shown to be augmented following stimulation with antigens or mitogens (Wecker et al. 1977; Moroni and Schumann 1975). Finally, it has been reported that some humoral and cellular immune responses could be inhibited in vitro and in vivo by anti-gp70 antibodies (Moroni and Schumann 1977; Theofllopoulos et al. 1981).

Keywords

Leukemia Gall Deoxyuridine C57L C57BR 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1982

Authors and Affiliations

  • Herbert C. MorseIII
    • 1
  • Janet W. Hartley
    • 1
  1. 1.Laboratory of Microbial Immunity and Laboratory of Viral DiseasesNational Institute of Allergy and Infectious DiseasesBethesdaUSA

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