Abstract
Growth of malignant lymphomas depends in part on the proliferation of atypical lymphoid cells. We evaluated after incorporation of tritiated thymidine the rate of proliferation of lymphoid cells homing to the skin in cutaneous T cell lymphomas (CTCL). The proportion of lymphoma cells in the dermal infiltrate was determined by optical and transmission electron microscopy.
Lymphoid cells synthezising DNA in patch and plaque stages of low grade CTCL were mainly located around the superficial vascular plexus. In nodules of high grade CTCL lymphoid cells in S phase were distributed both in the adventitial and reticular dermis.
Considering the overall labeling index in the infiltrate, the proliferation of the low grade CTCL was lower than that of the high grade CTCL. This represents a prognostic factor closely related [1] to the distribution of “blast” cells in the dermis, [2] to the cytology of lymphoma, and [3] to the survival rate of patients.
The proportion of cells synthesizing DNA among the atypical lymphoid cells proved with constancy to be near 30%. This indicates that most of the atypical lymphoid cells belong to the proliferative cell pool and seem to be little influenced by the type and stage of CTCL.
In normal conditions, lymphocytes almost exclusively multiply in the lymphoid organs to give rise to smaller cell variants with limited capacity to proliferate. In inflammatory conditions affecting the skin, lymphoblastogenesis was reported to occur at a low rate in blood and dermis [1–10].
Growth of malignant lymphomas must depend on the production of neoplastic cells that exceeds the rate of output of these cells from the cycle of proliferation. As it appears in recent reviews [11, 12], the production of lymphoma cells is considerably high in the lymph nodes. There is, however, little information about the proliferation of lymphoma cells homing to the skin and in particular in lymphomas characterized by an apparently primary cutaneous infiltration of neoplastic T cells, the “cutaneous T cell lymphomas” (CTCL) [13–17].
The aim of this work is to correlate the rate of proliferation of CTCL with the cytology and the histologic pattern of distribution of the neoplastic cells in the skin.
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Pierard, G.E., Franchimont, C., Le, T., de la Brassinne, M., Lapiere, C.M. (1982). Proliferation Rate of Cutaneous T Cell Lymphomas in the Skin — Relationship with Histologic Pattern and Cytology. In: Goos, M., Christophers, E. (eds) Lymphoproliferative Diseases of the Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68363-3_7
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DOI: https://doi.org/10.1007/978-3-642-68363-3_7
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