Origin and Functions of Langerhans Cells and Their Role in Disease

  • G. Stingl
  • K. Wolff


Using a gold chloride staining technique, Paul Langerhans [1] discovered dendritic cells in the suprabasal regions of the epidermis, which now bear his name. For almost a century, it was thought that Langerhans cells (LC) were either a component of the peripheral nervous system or, alternatively, that they were somehow related to melanocytes (rev. in 2). In the 1960s, these concepts were strongly challenged, widely disproven, and therefore abandoned. At the same time, some evidence was accumulating to suggest a mesenchymal origin of LC [2], and as a consequence, there was a resurgence of interest in these cells which stimulated experimental studies resulting in the elucidation of their origin and several of their functional properties.


Mycosis Fungoides Mixed Leukocyte Reaction Thymic Extract Cell Dependent Immune Response Histiocytic Proliferative Disorder 
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  1. 1.
    Langerhans R (1868) Über die Nerven der menschlichen Haut. Virchows Arch Pathol Anat 44: 325–337CrossRefGoogle Scholar
  2. 2.
    Wollf K (1972) The Langerhans Cell. Curr Probl Dermatol 4: 79–145Google Scholar
  3. 3.
    Rowden G, Lewis MG, Sullivan AK (1977) Ia antigen expression on human epidermal Langerhans cells. Nature 268: 247–248PubMedCrossRefGoogle Scholar
  4. 4.
    Klareskog L, Malmnäs-Tjernlund U, Forsum U, Peterson PA (1977) Epidermal Langerhans cells express la antigens. Nature 268: 248–250PubMedCrossRefGoogle Scholar
  5. 5.
    Stingl G, Katz SI, Shevach EM, Wolff- Schreiner E, Green I (1978) Detection of Ia antigens on Langerhans cells in guinea pig skin. J Immunol 120: 570–578PubMedGoogle Scholar
  6. 6.
    Fithian E, Kung P, Goldstein G, Rubenfeld M, Fenoglio C, Edelson RL (1981) Reactivity of Langerhans cells with hybridoma antibody. Proc Natl Acad Sci 78: 2541–2544PubMedCrossRefGoogle Scholar
  7. 7.
    Majdic O, Stingl G, Liszka K, Hönigsmann H, Knapp W (1981) Monoclonal antibody reactive with a cytoplasmic antigen present in B-lymphocytes and certain mononuclear phagocytes. J Invest Dermatol 76: 309AGoogle Scholar
  8. 8.
    Birbeck MS, Breathnach AS, Everall JD: (1961) An electron microscopic study of basal melanocyte and high level clear cell ( Langerhans cell) in vitiligo. J Invest Dermatol 37: 51–64Google Scholar
  9. 9.
    Stingl G (1980) New aspects of Langerhans’ cell function. Int J Dermatol 19: 189–213PubMedCrossRefGoogle Scholar
  10. 10.
    Caputo R, Peluchetti D, Monti M (1976) Freeze-fracture of Langerhans granules. A comparative study. J Invest Dermatol 66: 297–301PubMedCrossRefGoogle Scholar
  11. 11.
    Stingl G, Wolff-Schreiner EC, Pichler W, Gschnait F, Knapp W, Wolff K (1977) Epidermal Langerhans cells bear Fc and C3 receptors. Nature 258: 245–246CrossRefGoogle Scholar
  12. 12.
    Tamaki K, Stingl G, Gullino M, Sachs DH, Katz SI (1979) Ia antigens in mouse skin are predominantly expressed on Langerhans cells. J Immunol 123: 784–787PubMedGoogle Scholar
  13. 13.
    Schwartz BD, Kask AM, Paul WE, Shevach EM (1976) Structural characteristics of the alloantigens determined by the major histocompatibility complex of the guinea pig. J Exp Med 143: 541–558PubMedCrossRefGoogle Scholar
  14. 14.
    Thomas DW, Clement L, Shevach EM (1978) T lymphocyte stimulation by hapten-conjugated macrophages: a model system for the study of immunocompetent cell interactions, Immunol Rev 40: 181–204PubMedCrossRefGoogle Scholar
  15. 15.
    Stingl G, Katz SI, Clement L, Green I, Shevach EM (1978) Immunologic functions of Ia-bearing epidermal Langerhans cells. J Immunol 121: 2005–2013PubMedGoogle Scholar
  16. 16.
    Stingl G, Stingl-Gazze LA, Aberer W, Wolff K (1981) Antigen presentation by murine epidermal Langerhans cells and its alteration by ultraviolet B light. J Immunol (to be published )Google Scholar
  17. 17.
    Streilein JW, Toews GB, Bergstresser PR (1979) Corneal allografts fail to express Ia antigens. Nature 282: 326–327PubMedCrossRefGoogle Scholar
  18. 18.
    Bergstresser PR, Streilein JW (1981) Tape stripping of murine skin removes epidermal Langerhans cells and permits prolonged allograft survival. J Invest Dermatol 76: 334AGoogle Scholar
  19. 19.
    Kuntz MM, Innes JB, Weksler ME (1976) Lymphocyte transformation induced by autologous cells. IV. Human T lymphocyte proliferation induced by autologous or allogeneic non-T lymphocytes. J Exp Med 143: 1042–1053PubMedCrossRefGoogle Scholar
  20. 20.
    Wolff K, Schreiner E (1970) Uptake, intracellular transport and degradation of exogenous protein by Langerhans cells. An electron microscopic cytochemical study using peroxidase as tracer substance. J Invest Dermatol 54: 37–47PubMedCrossRefGoogle Scholar
  21. 21.
    Wolff K (1967) Die Langerhans-Zelle. Ergebnisse neuerer experimenteller Untersuchungen. I und II. Arch Klin Exp Dermatol 229: 54–101PubMedCrossRefGoogle Scholar
  22. 22.
    Katz SI, Tamaki K, Sachs DH (1979) Epidermal Langerhans cells are derived from cells originating in the bone marrow. Nature 282: 324–326PubMedCrossRefGoogle Scholar
  23. 23.
    Toews GB, Bergstresser PB, Streilein JW, Sullivan S (1980) Epidermal Langerhans cell density determines whether contact hypersensitivity or unresponsiveness follows skin painting with DNFB. J Immunol 124: 445–453PubMedGoogle Scholar
  24. 24.
    Lichtenstein L (1953) Histiocytosis X: Integration of eosinophilic granuloma of bone, “Letterer-Siwe disease” and “Schüller-Christian disease” as related manifestations of a single nosological entity. Arch Pathol Lab Med 56: 84–102Google Scholar
  25. 25.
    Basset F, Turiaf J (1965) Identification par la microscopie électronique de particules de nature probablement virale dans les lésions granulomateuses d’une histiocytose “X” pulmonaire. CR Acad Sci Paris 261: 3701–3703Google Scholar
  26. 26.
    Basset F, Nezelof C (1966) Présence en microscopie électronique de structures fila- menteuses originales dans les lésions pulmonaires et osseuses de l’histiocytose X. Etat actuel de la question. Soc Med Hôp Paris 117: 413–426Google Scholar
  27. 27.
    Cancilla PA, Lahey ME, Carnes WH (1967) Cutaneous lesions of Letterer-Siwe disease. Electron microscopic study. Cancer 20: 1986–1991PubMedCrossRefGoogle Scholar
  28. 28.
    Gianotti F, Caputo R, Ranzi T (1968) Ultrastructural study of giant cells and “Langerhans cell granules” in cutaneous lesions and lymph node and liver biopsies from four cases of subacute disseminated histiocytosis of Letterer-Siwe. Arch Klin Exp Dermatol 233: 238–252PubMedCrossRefGoogle Scholar
  29. 29.
    Nezelof C, Diebold N, Rousseau-Merck MF (1977) Ig surface receptors and erythrophagocytic activity of histiocytosis X cells in vitro. J Pathol 122: 105–113PubMedCrossRefGoogle Scholar
  30. 30.
    Osband ME, Lipton JM, Lavin P, Levey R, Vawter G, Greenberger JS, McCaffrey RP, Parkman R (1981) Histiocytosis-X. Demonstration of abnormal immunity, T cell histamine H2-receptor deficiency, and successful treatment with thymic extract. N Engl J Med 304:146–153PubMedCrossRefGoogle Scholar
  31. 31.
    Rowden G, Phillips TM, Lewis MG, Wilkinson RD (1979) Target role of Langerhans cells in mycosis fungoides. Transmission and immunoelectron microscopy. J Cutan Pathol 7: 364–382CrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1982

Authors and Affiliations

  • G. Stingl
  • K. Wolff

There are no affiliations available

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