Origin and Functions of Langerhans Cells and Their Role in Disease
Using a gold chloride staining technique, Paul Langerhans  discovered dendritic cells in the suprabasal regions of the epidermis, which now bear his name. For almost a century, it was thought that Langerhans cells (LC) were either a component of the peripheral nervous system or, alternatively, that they were somehow related to melanocytes (rev. in 2). In the 1960s, these concepts were strongly challenged, widely disproven, and therefore abandoned. At the same time, some evidence was accumulating to suggest a mesenchymal origin of LC , and as a consequence, there was a resurgence of interest in these cells which stimulated experimental studies resulting in the elucidation of their origin and several of their functional properties.
KeywordsMycosis Fungoides Mixed Leukocyte Reaction Thymic Extract Cell Dependent Immune Response Histiocytic Proliferative Disorder
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