Relevance of Morphometry in the Diagnosis and Prognosis of Cutaneous T Cell Lymphomas

  • C. J. L. M. Meijer
  • E. M. van der Loo
  • E. Scheffer
  • C. J. Cornelisse
  • W. A. van Vloten
Conference paper

Abstract

Mycosis fungoides (MF) and Sézary’s Syndrome (SS) are epidermotropic variants of cutaneous T cell lymphomas (CTCL) [3], characterized by the presence of lymphoid cells which ultrastructurally show deep and narrow nuclear (ceribriform) identations, condensed chromatin along the nuclear membrane, and scanty cytoplasm poor in organelles. These ceribriform mononuclear cells (CMC) have T cell membrane characteristics [14,22] lack surface membrane immunoglobulin [22] and C3 and Fcγ receptors [22], and show paranuclear dots of alpha naphthyl acetate esterase and acid phosphatase [8]. They may have Fcμ receptors [28] and certain differentiation antigens (OKT 4) which are characteristics for helper T cells. These cells form morphologically, immunologically, and enzymecyto-chemically a distinct subpopulation of T cells. Similar cells have been demonstrated in chronic benign skin lesions [6] such as chronic eczema, lichen planus, contact dermatitis, the synovial membrane [24] and fluid [23] of patients with rheumatoid arthritis, human cord blood [10], and peripheral blood of healthy donors [10]. These cells also form morphologically, immunologically, and enzyme-cytochemically a distinct subpopulation of T cells [18]. CMC in patients with MF and SS differ from CMC in healthy individuals in 1) DNA content, [26] 2) nuclear size [15] (nuclear diameter) and 3) nuclear shape [11] (degree of nuclear indentation).

Keywords

Formalin Arthritis Lymphoma Sedimentation Eter 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1982

Authors and Affiliations

  • C. J. L. M. Meijer
  • E. M. van der Loo
  • E. Scheffer
  • C. J. Cornelisse
  • W. A. van Vloten

There are no affiliations available

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