Abstract
Photochemotherapy using systemic 8-methoxypsoralen combined with exposure to longwave ultraviolet light (PUVA) has been found to be an effective treatment, particularly for the early and intermediate stages of mycosis fungoides (Gilchrest et al. 1976; Hjortshoj and Schmidt, 1977; Hodge et al. 1977; Roenigk, 1977; Konrad et al. 1978; Bleehen et al. 1978; Vella Briffa et al. 1980). In most patients with the early stages of the disease there is a rapid clearance of the lesions with alleviation of pruritus. However, several histologic studies (Lowe et al. 1979; Mackie et al. 1980) have indicated that despite the clinical improvement there was a persistence of the cutaneous infiltrate following PUVA, especially in the lower dermis.
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References
Bleehen SS, Vella Briffa D, Warin AP (1978) Photochemotherapy in mycosis fungoides. Clin Exp Dermatol 3:377–87
Chu AC, Smith N, MacDonald DM (1980) Evaluation of staining methods for resin embedded cutaneous tissue sections of mycosis fungoides. Br J Dermatol 103:607–613
Edelson RL (1980) Cutaneous T cell lymphoma:Mycosis Fungoides, Sézary syndrome, and other variants. J Am Acad Dermatol 2:89–106
Fuks ZY, Bagshaw MA, Farber EM (1973) Prognostic signs and management of mycosis fungoides. Cancer 32:1385–97
Gilchrest BA, Parrish JA, Tannenbaum L, Haynes HA, Fitzpatrick TB (1976) Oral methoxsalen photochemotherapy of mycosis fungoides. Cancer 38:683–89
Hodge L, Vella Briffa D, Warin AP, Gange RW, Bleehen SS (1977) Phtochemotherapy in mycosis fungoides. Br Med 2:1257–59
Hjortshoj A, Schmidt H (1977) Photochemotherapy of mycosis fungoides. Dan Med Bul 24:40–2
Huber JD, Parker F, Odland GF (1968) A basic fuchsin and alkalinized methylene blue rapid stain for epoxy-embedded tissue. Stain Technol 43:83
Konrad K, Gschnait F, Hönigsmann H, Fritsch P, Wolff K (1978) Photochemotherapie bei Mycosis fungoides. Der Hautarzt 29:191–97
Lowe NJ, Cripps DJ, Dufton PA, Vickers CFH (1979) Photochemotherapy for mycosis fungoides. A clinical and histological study. Arch Dermatol 115:50–3
Mackie RM, Foulds IS, McMillan EM, Nelson HM (1980) Histological changes observed in the skin of patients with mycosis fungoides receiving photochemotherapy. Clin Exp Dermatol 5:405–13
Molin L, Skogh M, Volden G (1978) Successful PUVA treatment in the tumor stage of mycosis fungoides associated with the appearance of lesions in organs other than the skin. Acta Derm Venereol (Stockh) 58:189–190
Roenigk HH (1977) Photochemotherapy for mycosis fungoides. Arch Dermatol 113:1047–51
Vella Briffa D, Warin AP, Harrington CI, Bleehen SS (1980) Photochemotherapy in mycosis fungoides:A study of 73 patients. The Lancet 2:49–53
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© 1982 Springer-Verlag Berlin Heidelberg
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Bleehen, S.S. (1982). Light and Electron Microscopic Studies on Mycosis Fungoides During Long-Term PUVA-Treatment. In: Goos, M., Christophers, E. (eds) Lymphoproliferative Diseases of the Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68363-3_13
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DOI: https://doi.org/10.1007/978-3-642-68363-3_13
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-11222-8
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